The Predictive Role of Systemic Immune Inflammation Index to the Aortic Valve Calcification in the Elderly Population with Chronic Renal Failure

Basit Öğe Kaydı
dc.contributor.authorYURDAM, Ferhat Siyamend
dc.contributor.authorKIŞ, Mehmet
dc.date.accessioned2024-03-09T20:43:12Z
dc.date.available2024-03-09T20:43:12Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractObjectives: Aortic valve calcification (AVC) is a chronic, degenerative and progressive condition that results of endothelial injury, cholesterol deposition, myofibroblast differentiation and subsequent valve calcification, involving complex pathophysiological mechanisms such as the activation of inflammatory and immune system cells. The frequency of AVC increased in the presence of chronic renal failure (CRF) and with age. The study aimed to reveal the relationship between AVC and systemic immune inflammation index (SII) that includes peripheral neutrophil, lymphocyte and platelet counts in the elderly population with chronic renal failure. Materials and Methods: Patients over 65 years of age who applied to the cardiology outpatient clinic with chronic renal failure between March 2018 and October 2022 were included in the study. The patients were divided into two groups as group 1 (control group- undetected AVC on echocardiography) (70 patients) and group 2 (AVC detected on echocardiography) (70 patients). SII of all patients was defined as: SII = neutrophil count × platelet count/lymphocyte count. Our study was a retrospective, observational study. Results: The mean SII value was statistically significantly higher in group 2 (754.2±268.7) than group 1 (622.79±297.2, p=0.007). In the univariable regression analysis of the factors affecting AVC in elderly patients with CRF, neutrophil [odds ratio (OR): 0.752; 95% confidence interval (CI): 0.605-0.934, p=0.01], lymphocytes (OR: 2,197; 95% CI: 1,346-3,585, p=0.002), and SII (OR: 0.998; 95% CI: 0.997-1.000, p=0.009) were predictors. In the multivariable regression analysis: SII (OR: 1.002; 95% CI: 1.000-1.005, p=0.034), lymphocytes (OR: 5,660; 95% CI: 2,349-13,637, p<0.001) and neutrophil (OR: 497; 95% CI: 0.344-0.717, p<0.001) were found to be independent predictors. SII> 633.4, 64% sensitivity, and 65% specificity (receiver operating characteristic area under curve: 0.672, 95% CI: 0.582-0.762, p<0.001) are associated with aortic valve sclerosis. Conclusion: High SII in the elderly with chronic renal failure is associated with the presence of AVCs.en_US
dc.identifier.doi10.32596/ejcm.galenos.2023.2023-01-02
dc.identifier.endpage16en_US
dc.identifier.issn2147-1924
dc.identifier.issue1en_US
dc.identifier.startpage11en_US
dc.identifier.trdizinid1179986en_US
dc.identifier.urihttps://doi.org/10.32596/ejcm.galenos.2023.2023-01-02
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1179986
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1694
dc.identifier.volume11en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofE Journal of Cardiovascular Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Predictive Role of Systemic Immune Inflammation Index to the Aortic Valve Calcification in the Elderly Population with Chronic Renal Failureen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
1694.pdf
Boyut:
560.02 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu