Comparison of Tissue and Urine Microbiota in Male, Intervention Naive Patients with and without Non-Invasive Bladder Cancer

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dc.authoridOZER, MUHAMMED SELCUK/0000-0002-5238-2691
dc.authoridDeger, Muslim Dogan/0000-0002-5095-7770
dc.authoridSen, Volkan/0000-0003-2832-0682
dc.authoridYildiz, Huseyin Alperen/0000-0002-7423-4585
dc.contributor.authorOzer, Muhammed S.
dc.contributor.authorIncir, Canet
dc.contributor.authorYildiz, Huseyin A.
dc.contributor.authorDeger, Muslim D.
dc.contributor.authorSarikaya, Alper E.
dc.contributor.authorTuncok, Yesim
dc.contributor.authorErgor, Gul
dc.date.accessioned2025-03-20T09:50:46Z
dc.date.available2025-03-20T09:50:46Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractIntroduction: To investigate the presence of dysbiosis in patients with naive bladder cancer. Methods: Twelve male patients with non-invasive bladder cancer and twelve age-matched healthy males had midstream urine and tissue samples taken. A history of endourological interventions was determined as an exclusion criterion, ensuring that the study was designed solely with na & iuml;ve participants. The bacterial 16s ribosomal RNA V3-V4 regions were used to examine urine and tissue samples. We compared the microbiota composition of the bladder cancer and control groups. Results: Escherichia Shigella (p < 0.001), Staphylococcus (p < 0.001), Delftia (p < 0.001), Acinetobacter (p < 0.001), Corynebacterium (p < 0.001), and Enhydrobacter (p < 0.001) were abundant in bladder cancer tissue samples. Escherichia Shigella (p < 0.001), Ureaplasma (p < 0.001), Lactobacillus (p = 0.005), Stenotrophomonas (p < 0.001), Streptococcus (p < 0.001), Corynebacterium (p < 0.001), and Prevotella (p = 0.039) were abundant in bladder cancer urine samples. Midstream urine has a sensitivity of 83% for detecting dysbiotic bacteria in cancer tissue. Conclusions: Our research is the first microbiota study of bladder cancer done with naive patients who have never had an endourological intervention. Escherichia Shigella, Staphylococcus, Acinetobacter, Enhydrobacter, Delftia, Corynebacterium, and Pseudomonas were detected as dysbiotic bacteria in bladder cancer. The sensitivity of the midstream urine sample in detecting dysbiosis in tissue is 83%. (c) 2024 S. Karger AG, Basel
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [217S075]
dc.description.sponsorshipThis study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) with project No. 217S075. This paper was presented as abstract at the 15th Uroocology Congress that was held in Association of UroOncology (Turkey).
dc.identifier.doi10.1159/000541296
dc.identifier.issn0042-1138
dc.identifier.issn1423-0399
dc.identifier.pmid39307134
dc.identifier.scopus2-s2.0-85207361351
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1159/000541296
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2301
dc.identifier.wosWOS:001335455100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofUrologia Internationalis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectUrinary bladder neoplasms
dc.subjectMicrobiota
dc.subject16S rRNA
dc.titleComparison of Tissue and Urine Microbiota in Male, Intervention Naive Patients with and without Non-Invasive Bladder Cancer
dc.typeArticle

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