Evaluation of coagulation parameters according to serum CRP levels in early stage COVID-19 patients

Basit Öğe Kaydı
dc.authorscopusid58250298000
dc.authorscopusid12771156700
dc.authorscopusid15845843300
dc.authorscopusid57190765494
dc.authorscopusid41862232000
dc.authorscopusid35119663300
dc.authorscopusid56241221800
dc.contributor.authorKardesler S.
dc.contributor.authorBozdemir A.E.
dc.contributor.authorKarakoyun I.
dc.contributor.authorArslan F.D.
dc.contributor.authorParildar H.
dc.contributor.authorYilmaz N.
dc.contributor.authorBasok B.I.
dc.date.accessioned2024-03-09T19:39:59Z
dc.date.available2024-03-09T19:39:59Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractObjectives: An increase in the levels of inflammatory biomarkers is observed in coronavirus disease (COVID-19). Coagulopathy occurring during the course of the disease has also been associated with inflammation. In our study, we aimed to evaluate the coagulation parameters according to the severity of inflammation in patients with early stage COVID-19 disease. Methods: The study was carried out retrospectively in a third-level hospital between April 8 and August 20, 2020. The patients were divided into two groups according to polymerase chain reaction (PCR) results. Non-COVID-19 group consisted of 72 patients with negative, and COVID-19 group consisted of 247 patients with positive PCR results. According to the serum C-reactive protein (CRP) levels the COVID-19 patients were divided into three groups as follows: Group1 (CRP<10 mg/L; n=105), Group 2 (CRP 10-50 mg/L; n=72), and Group 3 (CRP >50 mg/L; n=70). Age, CRP, and coagulation parameters including fibrinogen, D-dimer, aPTT, and PT were compared between the groups. Results: There were significant differences between the non-COVID-19 and COVID-19 patients in terms of age, CRP and coagulation parameters. Likewise, there was a significant difference among 3 groups regarding coagulation parameters. In the multinomial logistic regression analysis, only level of D-dimer was an independent risk factor among all groups, while PT was an independent risk factor between Groups 1, and 3. Conclusion: Our findings suggest that coagulopathy occurs in the early stage in relation to the severity of inflammation. For the diagnosis of COVID-19 disease and the detection of thrombotic complications; it is important to monitor results of the coagulation tests along with markers of inflammation from the early stages of the disease. © 2023, Kare Publishing. All rights reserved.en_US
dc.description.sponsorshipreceived no financial support.en_US
dc.identifier.doi10.14744/ijmb.2023.77698
dc.identifier.endpage68en_US
dc.identifier.issn2587-2362
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85159367476en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage63en_US
dc.identifier.trdizinid1177811en_US
dc.identifier.urihttps://doi.org/10.14744/ijmb.2023.77698
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1177811
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1609
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKare Publishingen_US
dc.relation.ispartofInternational Journal of Medical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectC-reactive protein; Coagulation; COVID-19; inflammationen_US
dc.titleEvaluation of coagulation parameters according to serum CRP levels in early stage COVID-19 patientsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
1609.pdf
Boyut:
131.52 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu