Ellagic acid increases implantation rates with its antifibrotic effect in the rat model of intrauterine adhesion

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dc.authoridSaribas, Sanem Gulistan/0000-0001-7582-6235
dc.authoridçelik, ekin/0000-0003-1966-3907
dc.authoridErgoren, Mahmut Cerkez/0000-0001-9593-9325
dc.authorwosidSaribas, Sanem Gulistan/Q-6648-2016
dc.authorwosidçelik, ekin/JXM-5937-2024
dc.authorwosidErgoren, Mahmut Cerkez/D-8491-2018
dc.contributor.authorSaribas, Gulistan Sanem
dc.contributor.authorDizakar, Ozen Akarca
dc.contributor.authorOzogul, Candan
dc.contributor.authorCelik, Ekin
dc.contributor.authorErgoren, Mahmut Cerkez
dc.date.accessioned2024-03-09T18:48:29Z
dc.date.available2024-03-09T18:48:29Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractIntrauterine adhesions (IUA) are defined as the adhesion of opposing endometrial tissue with dense fibrous adhesive bands within the uterine cavity. With the increase in cesarean sections and endometrial surgical pro-cedures, intrauterine adhesions have become a problem with increasing incidence and decreasing implantation. The purpose of the study was to investigate the effect of ellagic acid (EA), a phenolic compound, on fibrosis in IUA model rats. Another goal of the study was to increase endometrial receptivity with EA. The groups in the study were planned as control, DMSO, EA, IUA, IUA+DMSO, and IUA+EA, with 8 Sprague Dawley rats in each group. EA was administered at a dose of 100 mg/kg/day for 35 days. At the end of the experiment, the uterine tissues of the rats were removed. Histochemical staining was used to validate the IUA model and determine the degree of fibrosis. The levels of some fibrosis-related genes and proteins in the obtained uterine tissues were evaluated. In addition, implantation rates were determined. In our findings, it was observed that the fibrotic structure was decreased in the treated IUA+EA group compared to the IUA group, while fibrotic improvement was supported by down-regulation of TGF & beta;1 activity and up-regulation of BMP7 activity. The increase in the expression of the endometrial marker LIF with EA treatment was consistent with the increase in implantation rates with treatment. As a result of the study, it can be said that EA applied as a treatment against IUA causes healing in uterine tissue by reducing fibrosis and increases implantation rates by increasing endometrial receptivity.en_US
dc.description.sponsorshipScientific Researches Project Unit at Near East University [GRN-2019-1-001]en_US
dc.description.sponsorshipFunding This work was supported by the Scientific Researches Project Unit at Near East University [grant number GRN-2019-1-001] .en_US
dc.identifier.doi10.1016/j.prp.2023.154499
dc.identifier.issn0344-0338
dc.identifier.issn1618-0631
dc.identifier.pmid37163881en_US
dc.identifier.scopus2-s2.0-85156194522en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.prp.2023.154499
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1334
dc.identifier.volume246en_US
dc.identifier.wosWOS:001039768300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofPathology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAsherman Syndrome; Ellagic Acid; Fibrosis; Intrauterine Adhesionen_US
dc.titleEllagic acid increases implantation rates with its antifibrotic effect in the rat model of intrauterine adhesionen_US
dc.typeArticleen_US

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