Biological variation of thyroid stimulating hormone, free triiodothyronine and free thyroxine in healthy subjects in Turkey

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dc.contributor.authorYıldız, Raziye
dc.contributor.authorÖzkanay, Hayat
dc.contributor.authorArslan, Fatma Demet
dc.contributor.authorKöseoğlu, Mehmet
dc.date.accessioned2025-03-20T09:44:59Z
dc.date.available2025-03-20T09:44:59Z
dc.date.issued2025
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractIntroduction: Biological variation (BV) data are necessary for interpretation of test results and assessment of analytical performance. We aimed to determine the BV estimates for thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine(fT4) in healthy subjects in Turkey and compare them with the literature findings. Materials and methods: A total of 21 Turkish healthy volunteers (12 males and 9 females) were included in the study. Blood samples were collected once a week for five weeks, and the analysis was performed using the chemiluminescent immunoassay method on an Advia Centaur XP (Siemens Diagnostic, Tarrytown, USA). Analytical variation (CVA), within-subject BV (CVI) and between-subject BV (CVG) were calculated. Analytical goals, individuality index (II) and reference change value (RCV) were derived from these data. Statistical analysis was performed using BioVar: BV analysis tool v.1.0. Results: For TSH, fT3 and fT4, CVA (confidence interval, CI) were 3.3% (2.9 to 3.8), 1.7% (1.5 to 1.9) and 2.7% (2.4 to 3.1); CVI (CI) were 22.3% (19.3 to 26.3), 4.4% (3.8 to 5.3) and 5.1% (4.3 to 6.1); CVG (CI) were 26.6% (19.2 to 39.8), 9.2% (6.9 to 13.6) and 8.2% (6.1 to 12.1), respectively. For TSH, fT3 and fT4, desirable total errors were 27.1%, 6.2% and 6.6%; II values were calculated as 0.84, 0.48 and 0.61; and RCV% values (decrease; increase) were - 40.3;67.6, - 10.4;11.6 and - 12.7;14.5, respectively. Conclusions: Our study provides updated BV data for thyroid function tests (TFTs) in healthy subjects in Turkey. As TFTs have shown a high degree of individuality, RCV should be preferred rather than population-based reference ranges in the assessment of serum concentrations. Our BV estimates were compatible with European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) BV meta-analysis data obtained using different immunoassay methods in different populations. © by Croatian Society of Medical Biochemistry and Laboratory Medicine.
dc.identifier.doi10.11613/BM.2025.010706
dc.identifier.issn1330-0962
dc.identifier.issue1
dc.identifier.pmid39974197
dc.identifier.scopus2-s2.0-85219043732
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.11613/BM.2025.010706
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2110
dc.identifier.volume35
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBiochemia Medica, Editorial Office
dc.relation.ispartofBiochemia Medica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250319
dc.subjectBiological variation
dc.subjectHealthy people
dc.subjectThyroid hormones
dc.subjectTurkey
dc.titleBiological variation of thyroid stimulating hormone, free triiodothyronine and free thyroxine in healthy subjects in Turkey
dc.typeArticle

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