Prediction of gestational diabetes mellitus and perinatal outcomes by plasma zonulin levels

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dc.authoridBayraktar, Burak/0000-0001-6233-4207
dc.authoridYurtcu, Nazan/0000-0003-4725-043X
dc.authoridGölbaşı, Hakan/0000-0001-8682-5537
dc.authoridAkpak, Yasam Kemal/0000-0002-1699-8667
dc.authoridoral, serkan/0000-0002-1311-6278
dc.authorwosidsoyer çalışkan, canan/HJA-3078-2022
dc.authorwosidBayraktar, Burak/AAZ-9608-2020
dc.authorwosidGölbaşı, Hakan/AAS-6783-2021
dc.authorwosidYurtcu, Nazan/AAR-4580-2021
dc.authorwosidAkpak, Yasam Kemal/G-8376-2012
dc.contributor.authorOral, Serkan
dc.contributor.authorCelik, Sebahattin
dc.contributor.authorAkpak, Yasam Kemal
dc.contributor.authorGolbasi, Hakan
dc.contributor.authorBayraktar, Burak
dc.contributor.authorUnver, Gokhan
dc.contributor.authorSahin, Sami
dc.date.accessioned2023-03-22T19:47:33Z
dc.date.available2023-03-22T19:47:33Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractPurpose Zonulin has been shown to be associated with many metabolic disorders, including type 2 diabetes mellitus, metabolic syndrome, and obesity. In this study, we aimed to evaluate the association between maternal plasma zonulin levels and gestational diabetes mellitus (GDM) and its perinatal outcomes. Materials A total of 100 pregnant women, 56 with GDM and 44 controls, were included in this prospective case-control study. Maternal plasma zonulin levels were evaluated in each trimester. The association between zonulin levels and GDM, body mass index (BMI) and adverse perinatal outcomes was evaluated. The GDM predictability of zonulin levels for each trimester was analyzed with the receiver operator curve (ROC). Results Plasma zonulin levels were significantly higher in pregnant with GDM in all trimesters (p < 0.001; for all). Optimum cut-off values of plasma zonulin levels in predicting GDM: first trimester: 6.27 ng/mL, second trimester: 12.71 ng/mL, and third trimester: 18.38 ng/mL. BMI was significantly higher in pregnant women with GDM (30.5 vs 26.1; p < 0.001). Zonulin levels were significantly higher in pregnant women with GDM with overweight BMI [>= 25-30 (kg/m(2))] in all trimesters (p < 0.05; for all). Zonulin levels were significantly higher in pregnant women with composite adverse outcomes that included at least one of neonatal intensive care unit (NICU) admission, meconium-stained amniotic fluid, and 1st minute APGAR score < 7. Conclusion Increased maternal plasma zonulin levels were associated with increased risk of GDM and adverse perinatal outcomes. Zonulin may be a potential marker to predict GDM risk and perinatal outcomes.en_US
dc.identifier.doi10.1007/s00404-022-06751-6
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.pmid35994108en_US
dc.identifier.scopus2-s2.0-85136588282en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-022-06751-6
dc.identifier.urihttps://hdl.handle.net/20.500.14034/766
dc.identifier.wosWOS:000842867800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.journalArchives Of Gynecology And Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectZonulinen_US
dc.subjectGestational diabetes mellitusen_US
dc.subjectIntestinal permeabilityen_US
dc.subjectGut Microbiotaen_US
dc.subjectSerum Zonulinen_US
dc.subjectIntestinal Permeabilityen_US
dc.subjectPregnancyen_US
dc.subjectHyperglycemiaen_US
dc.subjectBiomarkersen_US
dc.titlePrediction of gestational diabetes mellitus and perinatal outcomes by plasma zonulin levelsen_US
dc.typeArticleen_US

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