Non-heparin-induced thrombocytopenia in patients after open-heart surgery

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dc.authoridBilen, Çağatay/0000-0002-9158-5627
dc.authoridKELES, ERCAN/0000-0002-8866-3719
dc.authorwosidBilen, Çağatay/HKF-1055-2023
dc.contributor.authorKeles, Ercan
dc.contributor.authorBilen, Cagatay
dc.contributor.authorAygun, Hakan
dc.contributor.authorGencpinar, Tugra
dc.contributor.authorCatalyurek, Hudai
dc.date.accessioned2023-03-22T19:47:32Z
dc.date.available2023-03-22T19:47:32Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractBackground Thrombocytopenia (platelet count below 150 x 10(3)/mu L) is a common finding after open-heart surgery and can lead to various complications, including patient death. This study aimed to determine the extent of non-heparin-induced thrombocytopenia in open-heart surgery and to highlight the associated factors. Materials and Methods In this cohort study, 842 patients who underwent valve and/or coronary bypass surgery over a 5-year period were retrospectively analyzed. After open-heart surgery, patients whose platelet count was less than 150 x 10(3)/mu L on a complete blood count 12 and 24 h after surgery were classified as thrombocytopenic. Three hundred twenty patients without thrombocytopenia and 21 patients with a high probability of heparin-induced thrombocytopenia were excluded from the study. Logistic regression analysis was used to assess the association of independent variables in moderate-severe thrombocytopenia: Age groups, sex, underlying disease, symptoms, type of surgery, pump time, pulsatile or non-pulsatile duration, degree of hypothermia, hemodilution, oxygenator type, use of an intra-aortic balloon, and erythrocyte transfusion counts were included in the analysis. Results A total of 501 patients were diagnosed as having non-heparin-induced thrombocytopenia, and 64.3% were male. Three hundred seventy-seven (75.2%) patients had mild thrombocytopenia and 124 (24.7%) had moderate-severe thrombocytopenia. The postoperative platelet count was significantly lower than the preoperative platelet count (213 x 10(3) vs.117 x 10(3)/mu L; p < 0.001). Moderate-severe thrombocytopenia was associated with age >= 80 years odds (OR = 9.026, 95% CI: [1.757-46.363]; p = 0.008), isolated valve surgery (OR = 3.090, 95% CI: [1.867-5.114]; p < 0.001), and valve surgery with coronary bypass (OR = 4.938, 95% CI: [1.638-14.889]; p = 0.005) compared to isolated coronary bypass, type of oxygenator (Nipro vital compared with Affinity OR = 11.097, 95% CI: [1.923-64.023]; p = 0.007), erythrocyte transfusion count (OR = 1.219, 95%CI: [1.046-1.420]; p = 0.011). Conclusion Age 80 years or older, surgical procedures including heart-valve surgery, and the number of red blood cell transfusions are associated with the risk of moderate-to-severe thrombocytopenia. This study provides a guide in terms of risk factors that may lead to moderate-to-severe thrombocytopenia after open-heart surgery. However, future multicentre prospective randomized studies may provide more detailed information on this subject.en_US
dc.identifier.doi10.1177/02676591221082496
dc.identifier.issn0267-6591
dc.identifier.issn1477-111X
dc.identifier.pmid35377248en_US
dc.identifier.scopus2-s2.0-85129214190en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1177/02676591221082496
dc.identifier.urihttps://hdl.handle.net/20.500.14034/755
dc.identifier.wosWOS:000777943100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.journalPerfusion-Uken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectthrombocytopeniaen_US
dc.subjectopen-heart surgeryen_US
dc.subjectadult patienten_US
dc.subjectheparinen_US
dc.subjectAortic-Valve-Replacementen_US
dc.subjectCardiac-Surgeryen_US
dc.subjectRisk-Factorsen_US
dc.titleNon-heparin-induced thrombocytopenia in patients after open-heart surgeryen_US
dc.typeArticleen_US

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