Blood-Based Clinical Biomarkers of Inflammation and Nutrition in Hyperemesis Gravidarum

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dc.authoridBayraktar, Burak/0000-0001-6233-4207
dc.authoridDEMIR CENDEK, BUSRA/0000-0002-6338-1408
dc.authoridGolbasi, Hakan/0000-0001-8682-5537
dc.authoridIbanoglu, Mujde can/0000-0002-8413-2064
dc.contributor.authorCendek, Busra Demir
dc.contributor.authorBayraktar, Burak
dc.contributor.authorSeyhanli, Zeynep
dc.contributor.authorKocyildiz, Ezgi
dc.contributor.authorGolbasi, Hakan
dc.contributor.authorIbanoglu, Mujde Can
dc.contributor.authorUstun, Yaprak Engin
dc.date.accessioned2025-03-20T09:50:31Z
dc.date.available2025-03-20T09:50:31Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractBackground: In this study, the aim was to investigate blood-based clinical biomarkers of inflammation and nutrition indices in hyperemesis gravidarum (HG). Methods: This retrospective case-control study was conducted at a tertiary hospital between 2018 and 2022. A total of 820 pregnant women were enrolled in this study; 410 pregnant women were diagnosed with HG (HG group) at 6-14 weeks of gestation, and 410 pregnant women were healthy controls (control group) in the same gestational weeks. Patients' demographic and clinical characteristics and laboratory parameters were recorded. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, the modified-HALP (m-HALP) score, and the prognostic nutritional index (PNI) were calculated. Results: The HALP score (32.6 (IQR: 24.9-41.5) vs. 39.2 (IQR: 30.8-49.2), p < 0.001) and the PNI score (50 (IQR: 46.3-53.6) vs. 51.3 (IQR: 48.6-53.8), p < 0.001) were significantly lower in the HG group, whereas the m-HALP score was similar between the groups. The HALP score had an AUC of 0.625 (95% CI: 0.586-0.664), with the optimal cut-off value set at 35.8, resulting in a sensitivity of 59.7% and a specificity of 59.5% (p < 0.001). Similarly, the PNI score showed an AUC of 0.580 (95% CI: 0.541-0.619), and the optimal cut-off value was set at 50.6, resulting in a sensitivity of 54.9% and a specificity of 54.9% (p < 0.001). In regression analysis, lower HALP scores (OR: 0.906, 95% CI: 0.833-0.984, p = 0.019) and lower PNI scores (OR: 0.941, 95% CI: 0.891-0.995, p = 0.033) were significantly associated with HG, highlighting their potential as diagnostic markers. Additionally, a negative statistically significant correlation was observed between PNI scores and ketonuria (r = -0.073, p = 0.036). Conclusions: This study demonstrated a decrease in the HALP score and PNI score in cases of HG. However, the m-HALP score was similar in the HG and control groups.
dc.identifier.doi10.3390/jcm13237289
dc.identifier.issn2077-0383
dc.identifier.issue23
dc.identifier.pmid39685747
dc.identifier.scopus2-s2.0-85211770838
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm13237289
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2239
dc.identifier.volume13
dc.identifier.wosWOS:001377290700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjecthyperemesis gravidarum
dc.subjectinflammation
dc.subjectnutrition
dc.subjectHALP score
dc.subjectm-HALP score
dc.subjectprognostic nutritional index
dc.titleBlood-Based Clinical Biomarkers of Inflammation and Nutrition in Hyperemesis Gravidarum
dc.typeArticle

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