Protective Effects of Thymoquinone on Doxorubicin-induced Lipid Peroxidation and Antioxidant Enzyme Levels in Rat Peripheral Tissues

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dc.authorscopusid14047793200
dc.authorscopusid56063821600
dc.authorscopusid56259656000
dc.authorscopusid7006844760
dc.authorscopusid57197170055
dc.authorscopusid23097741000
dc.contributor.authorAkpinar D.
dc.contributor.authorMercan T.
dc.contributor.authorDemir H.
dc.contributor.authorOzdemir S.
dc.contributor.authorDemir C.
dc.contributor.authorKavak S.
dc.date.accessioned2024-03-09T19:40:00Z
dc.date.available2024-03-09T19:40:00Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractWe aimed to investigate the effects of thymoquinone (TQ) against Doxorubicin (DOX)-induced toxicity in liver, lung, kidney, testes, diaphragm and stomach tissues of rats. Healthy twenty-eight Wistar albino male rats aged three months, were divided into four groups, each containing seven animals: Group 1: Control (C group); the rats were injected intraperitoneally with saline 5 times every other day and given by gavage to the vehicle solution Group 2 (T group): Rats treated with thymoquinone (10mg/kg given by gavage), Group 3 (D group): Rats treated with doxorubicin were injected intraperitoneally (3mg/kg) and Group 4 (DT group): Rats treated with doxorubicin (injected intraperitoneally with 3mg/kg DOX) and thymoquinone (10mg/kg given by gavage). Group 2 (T group): TQ (10mg/kg) was administered by gavage at 24-hour intervals for 4 weeks. Saline (i.p.) was injected to rats 5 times every other day. Group 3 (D group): The rats were injected with 3 mg/kg DOX (i.p.) 5 times every other day. In addition, vehicle solution was administered by gavage at 24-h intervals for 4 weeks. Group 4 (DT group): Rats were injected with 3mg/kg DOX (i.p.) 5 times every other day. TQ (10mg/kg) was administered by gavage at 24-h intervals for 4 weeks. At the end of the experiment, the animals were euthanized with sodium pentobarbital (50 mg/kg) and their lung, liver, stomach, kidney, diaphragm and testicular tissues were removed for the measurement of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels. It was observed that DOX administration (in group D) increased lipid peroxidation and decreased antioxidant enzyme levels in the peripheral tissues of rats. It was determined that TQ treatment (in the DT group) given with DOX decreased lipid peroxidation and increased antioxidant enzyme levels. In our study, it was determined that TQ treatment eliminated the toxic effects of DOX and the protective effects of TQ were revealed. © 2023 University of Agriculture. All rights reserved.en_US
dc.description.sponsorshipWe would like to thank the employees of the experimental animal’s unit of Akdeniz University for their help and support.en_US
dc.identifier.doi10.29261/pakvetj/2023.070
dc.identifier.endpage658en_US
dc.identifier.issn0253-8318
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85173475238en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage651en_US
dc.identifier.urihttps://doi.org/10.29261/pakvetj/2023.070
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1621
dc.identifier.volume43en_US
dc.identifier.wosWOS:001163106100005
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversity of Agricultureen_US
dc.relation.ispartofPakistan Veterinary Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant Enzymes; Doxorubicin; Lipid Peroxidation; Peripheral Tissues; Rat; Thymoquinoneen_US
dc.subjectantioxidant; catalase; doxorubicin; glutathione peroxidase; malonaldehyde; pentobarbital; sodium chloride; superoxide dismutase; thymoquinone; animal experiment; animal model; animal tissue; Article; centrifugation; controlled study; drug toxicity; enzyme activity; lipid peroxidation; liver tissue; male; nonhuman; oxidative stress; rat; testis tissue; Wistar raten_US
dc.titleProtective Effects of Thymoquinone on Doxorubicin-induced Lipid Peroxidation and Antioxidant Enzyme Levels in Rat Peripheral Tissuesen_US
dc.typeArticleen_US

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