Risk factors for neurologic sequelae in children and adolescents with hemophilia after intracranial hemorrhage

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dc.authoridAkbayram, Sinan/0009-0001-0816-4144
dc.authoridAlbayrak, Davut/0000-0002-7947-3817
dc.contributor.authorEvim, Melike Sezgin
dc.contributor.authorUnuvar, Aysegul
dc.contributor.authorAlbayrak, Canan
dc.contributor.authorZengin, Emine
dc.contributor.authorYilmaz, Ebru
dc.contributor.authorKaya, Zuhre
dc.contributor.authorKaradas, Nihal
dc.date.accessioned2025-03-20T09:51:05Z
dc.date.available2025-03-20T09:51:05Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractBackground: Intracranial hemorrhage (ICH) is reportedly rare but has high morbidity and mortality risk in persons with hemophilia. Although the risk factors that facilitate bleeding are known, the factors affecting the sequelae are not well known. Objectives: We planned to investigate the risk factors for neurologic sequelae in children and adolescents with hemophilia suffering from ICH. Methods: An invitation was sent to pediatric hematology centers via email. Clinical and laboratory findings, neurologic sequelae, and recurrence of bleeding in persons with hemophilia who developed ICH were questioned. Results: Eighty-six patients from 21 centers were evaluated. All patients were less than 18 years of age at the time of ICH. Thirteen patients had ICH in the neonatal period, while 40 patients had a known diagnosis of hemophilia before ICH, and 33 patients were undiagnosed before ICH. Five patients died, 2 of whom died in the neonatal period. The rate of neurologic sequelae was 25 of 81 (30%). The most common neurologic sequela was epilepsy (n = 11/25), followed by hemiparesis (n = 5/25). Cerebral shift (odds ratio, 3.48) and development of ICH in the neonatal period (odds ratio, 4.67) were significant for the development of neurologic sequelae in multivariate analysis. On follow-up, recurrence of ICH occurred in 8 of 81 (10%). Conclusion: ICH in the neonatal period and cerebral shift were the two main risk factors for the development of neurologic sequelae. Neonatal departments must be alert to the signs of bleeding. It is important for healthcare professionals to overcome the barriers to primary prophylaxis and to take trauma-related precautions.
dc.identifier.doi10.1016/j.rpth.2024.102607
dc.identifier.issn2475-0379
dc.identifier.issue8
dc.identifier.pmid39687930
dc.identifier.scopus2-s2.0-85210283626
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.rpth.2024.102607
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2404
dc.identifier.volume8
dc.identifier.wosWOS:001371095900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofResearch and Practice in Thrombosis and Haemostasis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjectadolescents
dc.subjectchildren
dc.subjecthemophilia
dc.subjectintracranial hemorrhage
dc.subjectoutcome
dc.titleRisk factors for neurologic sequelae in children and adolescents with hemophilia after intracranial hemorrhage
dc.typeArticle

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