Evaluation of D-dimer levels measured by different analytical methods in COVID-19 patients

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dc.authoridArslan, Fatma Demet/0000-0003-0766-0303
dc.authoridArslan İnce, Fatma Demet/0000-0003-0766-0303
dc.authoridBasok, Banu Isbilen/0000-0002-1483-997X
dc.authoridTerzioglu, Mustafa/0009-0006-1486-5197
dc.authorwosidArslan, Fatma Demet/ABG-6885-2021
dc.authorwosidArslan İnce, Fatma Demet/AAZ-5735-2021
dc.authorwosidBasok, Banu Isbilen/AEJ-9148-2022
dc.authorwosidSenger, Süheyla Serin/C-8461-2009
dc.authorwosidColak, Ayfer Aydogdu/GQP-0855-2022
dc.contributor.authorArslan, Fatma Demet
dc.contributor.authorBasok, Banu Isbilen
dc.contributor.authorTerzioglu, Mustafa
dc.contributor.authorAltan, Tuba Kansu
dc.contributor.authorKaraca, Yeser
dc.contributor.authorSenger, Suheyla Serin
dc.contributor.authorColak, Ayfer
dc.date.accessioned2024-03-09T18:48:31Z
dc.date.available2024-03-09T18:48:31Z
dc.date.issued2022
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractClinicians experience some challenges due to the lack of standardization of test, although D-dimer is a prognostic marker for COVID-19. We compared the clinical and analytical performances of D-dimer results obtained from different devices, kits and methods in patients with a diagnosis of COVID-19. Thirty-nine patients with a diagnosis of COVID-19 and 24 healthy individuals were included in the study. D-dimer levels were measured with Innovance D-DIMER kit (immunoturbidimetric method) on Sysmex CS-2500 and BCS XP and VIDAS D-Dimer Exclusion II kit (enzyme-linked fluorescence method) on mini VIDAS. The studies of precision, method comparison and clinic performance were performed. The variation coefficients in all systems were within the acceptable imprecision (7.8%). Bias%(12.5%) between BCS XP and Sysmex CS-2500 was lower than the acceptable Bias%(15.5%). Bias% values (19.2% and 33.3%, respectively) between Mini VIDAS with BCS XP and Sysmex CS-2500 were higher than the acceptable Bias%. The correlation coefficients among all systems were 0.89-0.98. For 500 ng/ml FEU, there was almost perfect agreement between BCS XP and Sysmex CS-2500, a moderate agreement between Mini VIDAS and BCS XP and Sysmex CS-2500. The cut-off values for distinguishing between individuals with and withoutCOVID-19 were Mini VIDAS, Sysmex CS-2500 and BCS XP 529, 380 and 390 ng/ml FEU, respectively. The immunoturbidimetric method can be used as an alternative to the enzyme-linked fluorescent method because of satisfactory agreement at the different thresholds proposed for venous thromboembolism. However, it is recommended to follow up COVID-19 with the D-dimer results obtained by the same assay system.en_US
dc.identifier.doi10.1097/MBC.0000000000001129
dc.identifier.endpage215en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue4en_US
dc.identifier.pmid35239616en_US
dc.identifier.scopus2-s2.0-85131217395en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://doi.org/10.1097/MBC.0000000000001129
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1364
dc.identifier.volume33en_US
dc.identifier.wosWOS:000803050700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofBlood Coagulation & Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCovid-19; D-Dimer; Enzyme-Linked Fluorescent Method; Immunoturbidimetry; Venous Thromboembolismen_US
dc.titleEvaluation of D-dimer levels measured by different analytical methods in COVID-19 patientsen_US
dc.typeArticleen_US

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