Neurological recovery with interferon-gamma treatment in friedreich's ataxia

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dc.authorscopusid25222311100
dc.authorscopusid6602578908
dc.contributor.authorTekin Hande Gazeteci
dc.contributor.authorLevent Ertürk
dc.date.accessioned2023-03-22T19:47:53Z
dc.date.available2023-03-22T19:47:53Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractFriedreich's ataxia (FA) is a rare, progressive, and degenerative hereditary disorder caused by a deficiency of frataxin protein. This disease is characterised by severe neurological dysfunction and life-threatening cardiomyopathy. Various drugs are used to slow down / stop the neurodegenerative progress. However, recent clinical trials and animal experiments demonstrate that interferon- gamma (IFN-?) treatment might improve signs of FA as well. A 9-year-old girl was admitted to our hospital with gait instability, mild dysarthria, and sensorimotor polyneuropathy. Her genetic examination was consistent with FA. IFN-? treatment was started 3 times a week. The treatment was evaluated by physical examination and side effects assessment. Friedreich Ataxia Rating Scale (FARS), 9- hole peg test (9HPT), and time of 25-foot walk (T25FW) were measured. Ataxia and cerebellar findings improved within 9 months. Although clinical neurological improvement was achieved, there was no improvement in cardiomyopathy. © 2022 College of Physicians and Surgeons Pakistan. All rights reserved.en_US
dc.identifier.doi10.29271/jcpsp.2022.05.671
dc.identifier.endpage673en_US
dc.identifier.issn1022386X
dc.identifier.issue5en_US
dc.identifier.pmid35546709en_US
dc.identifier.scopus2-s2.0-85130631652en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage671en_US
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2022.05.671
dc.identifier.urihttps://hdl.handle.net/20.500.14034/896
dc.identifier.volume32en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCollege of Physicians and Surgeons Pakistanen_US
dc.relation.journalJournal of the College of Physicians and Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiomyopathyen_US
dc.subjectChildrenen_US
dc.subjectFARSen_US
dc.subjectFriedreich ataxiaen_US
dc.subjectInterferon-gammaen_US
dc.subjectgamma1b interferonen_US
dc.subjectidebenoneen_US
dc.subjectmetoprololen_US
dc.subjectubiquinoneen_US
dc.subjectgamma interferonen_US
dc.subjectareflexiaen_US
dc.subjectarm movementen_US
dc.subjectArticleen_US
dc.subjectcase reporten_US
dc.subjectchilden_US
dc.subjectclinical articleen_US
dc.subjectconvalescenceen_US
dc.subjectdysarthriaen_US
dc.subjectdysmetriaen_US
dc.subjectechocardiographyen_US
dc.subjectelectrocardiogramen_US
dc.subjectelectromyographyen_US
dc.subjectfemaleen_US
dc.subjectfinger to finger testen_US
dc.subjectfinger to nose testen_US
dc.subjectflu like syndromeen_US
dc.subjectfollow upen_US
dc.subjectFriedreich ataxiaen_US
dc.subjectFriedreich Ataxia Rating Scaleen_US
dc.subjectgenetic analysisen_US
dc.subjecthammertoeen_US
dc.subjectheart left ventricle hypertrophyen_US
dc.subjecthumanen_US
dc.subjecthypertrophic cardiomyopathyen_US
dc.subjectmotor dysfunctionen_US
dc.subjectmotor function testen_US
dc.subjectnerve conduction velocityen_US
dc.subjectneurologic disease assessmenten_US
dc.subjectneurologic gait disorderen_US
dc.subjectnine hole peg testen_US
dc.subjectpes cavusen_US
dc.subjectphysical examinationen_US
dc.subjectphysiotherapyen_US
dc.subjectschool childen_US
dc.subjectsensorimotor neuropathyen_US
dc.subjectwalk testen_US
dc.subjectcardiomyopathyen_US
dc.subjectcomplicationen_US
dc.subjectFriedreich ataxiaen_US
dc.subjectwalkingen_US
dc.subjectCardiomyopathiesen_US
dc.subjectFemaleen_US
dc.subjectFriedreich Ataxiaen_US
dc.subjectHumansen_US
dc.subjectInterferon-gammaen_US
dc.subjectWalkingen_US
dc.titleNeurological recovery with interferon-gamma treatment in friedreich's ataxiaen_US
dc.typeArticleen_US

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