Coenzyme q10 effectively prevents age-related hearing loss in c57bl/6 mice

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dc.authorscopusid6504495599
dc.authorscopusid55190592100
dc.authorscopusid57188536619
dc.authorscopusid22133472100
dc.contributor.authorMüderris, Togay
dc.contributor.authorSevil, Ergun
dc.contributor.authorYar Sağlam, A.S.
dc.contributor.authorBabademez, M.A.
dc.date.accessioned2022-02-15T16:58:10Z
dc.date.available2022-02-15T16:58:10Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractIntroduction: Presbycusis is characterized by gradual, progressive sensorineural hearing loss. The aim of this study is to evaluate the effects of coenzyme Q10 in the prevention and treatment of age-related hearing loss. Materials and Method: Thirty-two C57BL/6 mice were assigned into four groups as early treatment, late treatment, control and sham control. Treatment was started at three months of age in the early treatment group and at six months in the late treatment group. The auditory brainstem test was performed once every three months. At the end of the study period, the cochleae of the animals were harvested, and Bcl-2, Bcl-xL, iNOS, COX-2, NF-?B, Bax, and Bak levels were analyzed with real-time polymerase chain reaction. Results: The hearing thresholds of the mice in the early treatment group were better than those of the other groups (p < 0.001). Hearing levels were also better in the late treatment group than control groups, but the difference was not significant (p > 0.05). The threshold shift in the early treatment group was significantly lower than the control groups (p < 0.001). The mRNA expression levels of proapoptotic genes Bax and Bak were lower (p < 0.05), antiapoptotic genes Bcl-2 and Bcl-xL were higher (p < 0.05), and the NF-?B, COX-2, and iNOS genes, which play a role in inflammation, were lower (p < 0.05) in the early treatment group. Conclusion: These results suggest that coenzyme Q10 effectively attenuates the presentation of age-related hearing loss, especially when started before the onset of hearing loss. © 2021, Geriatrics Society. All rights reserved.en_US
dc.identifier.doi10.31086/tjgeri.2021.220
dc.identifier.endpage243en_US
dc.identifier.issn1304-2947
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85116143769en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage235en_US
dc.identifier.urihttps://doi.org/10.31086/tjgeri.2021.220
dc.identifier.urihttps://hdl.handle.net/20.500.14034/357
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeriatrics Societyen_US
dc.relation.journalTurk Geriatri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectEvoked Potentials, Auditory, Brain Stemen_US
dc.subjectOxidative Stressen_US
dc.subjectPresbycusisen_US
dc.subjectcyclooxygenase 2en_US
dc.subjectimmunoglobulin enhancer binding proteinen_US
dc.subjectinterleukin 10en_US
dc.subjectmessenger RNAen_US
dc.subjectprotein Baken_US
dc.subjectprotein Baxen_US
dc.subjectprotein bcl 2en_US
dc.subjecttumor necrosis factoren_US
dc.subjectubidecarenoneen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectauditory thresholden_US
dc.subjectbrain stemen_US
dc.subjectbrain stem responseen_US
dc.subjectcontrolled studyen_US
dc.subjectdown regulationen_US
dc.subjectevoked brain stem auditory responseen_US
dc.subjectforced vital capacityen_US
dc.subjectgene expressionen_US
dc.subjecthearing impairmenten_US
dc.subjectlipid peroxidationen_US
dc.subjectmouseen_US
dc.subjectmRNA expression levelen_US
dc.subjectMTT assayen_US
dc.subjectnonhumanen_US
dc.subjectoxidative stressen_US
dc.subjectperception deafnessen_US
dc.subjectprotein expressionen_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjectreverse transcription polymerase chain reactionen_US
dc.subjectRNA extractionen_US
dc.subjectRNA isolationen_US
dc.titleCoenzyme q10 effectively prevents age-related hearing loss in c57bl/6 miceen_US
dc.typeArticleen_US

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