Predicting adverse perinatal outcomes with fetal modified myocardial performance index and epicardial fat tissue thickness in diabetes-complicated pregnancies

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dc.authoridDemircan, Tulay/0000-0002-2529-2906
dc.authoridEkin, Atalay/0000-0002-4712-3927
dc.authorwosidAltin Ekin, Meryem/GZH-0330-2022
dc.authorwosidDemircan, Tulay/AAA-6752-2021
dc.contributor.authorOmeroglu, I.
dc.contributor.authorGolbasi, H.
dc.contributor.authorBayraktar, B.
dc.contributor.authorGolbasi, C.
dc.contributor.authorKaraca, S. Yildirim
dc.contributor.authorDemircan, T.
dc.contributor.authorEkin, A.
dc.date.accessioned2024-03-09T18:48:57Z
dc.date.available2024-03-09T18:48:57Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this study was to evaluate fetal modified myocardial performance index (mod-MPI) and fetal epicardial fat tissue (EFT) thickness and its association with adverse perinatal outcomes in diabetic pregnant women.PATIENTS AND METHODS: This was a prospective case-control study including 90 gestational diabetes mellitus (GDM) and 45 pregestational diabetes mellitus (PGDM) and 90 healthy pregnant women (control group). Two-dimensional gray-scale and Doppler fetal echocardiography were used to calculate the mod-MPI. EFT thickness was measured in the hypoecho-genic area between the myocardium and the visceral pericardium on the right ventricle by distinguishing it from the pericardial fluid by Doppler ultrasound. RESULTS: Both mod-MPI values and EFT thickness were significantly higher in diabetic pregnant women (p<0.001; for both). No significant differences were observed in mod-MPI values and EFT thickness between pregnant women with GDM and PGDM. In addition, there was no significant difference in fetal mod-MPI values and EFT thicknesses among diabetic pregnant women based on their treatment requirements. The receiver operating characteristic (ROC) curve revealed that mod-MPI value (cut-off 0.54, 95% CI: 0.629-0.837, p<0.001, sensitivity 64.6%, specificity 61.7%) and EFT thickness (cut-off 1.85 mm, 95% CI: 0.524-0.750, p=0.014, sensitivity 65.8%, specificity 63.9%) could predict adverse neonatal outcomes in diabetic pregnant women. Multivariate regression analysis revealed that both mod-MPI (p=0.003) and EFT thickness (p=0.008) were independently associated with adverse outcomes.CONCLUSIONS: Fetal mod-MPI values and EFT thickness increase in pregnancies complicated by diabetes, and these measurements may serve as valuable predictors of adverse perinatal outcomes.en_US
dc.identifier.endpage10630en_US
dc.identifier.issn1128-3602
dc.identifier.issue21en_US
dc.identifier.pmid37975387en_US
dc.identifier.scopus2-s2.0-85177443543en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage10620en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1535
dc.identifier.volume27en_US
dc.identifier.wosWOS:001110599700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes; Modified Myocardial Performance Index; Epicardial Adipose Tissue; Epicardial Fat Tissue; Pregnancyen_US
dc.titlePredicting adverse perinatal outcomes with fetal modified myocardial performance index and epicardial fat tissue thickness in diabetes-complicated pregnanciesen_US
dc.typeArticleen_US

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