Evaluation of analytical quality of coagulation parameters by sigmametric methodology

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dc.authorscopusid57194695019
dc.authorscopusid36628100500
dc.authorscopusid56241221800
dc.authorscopusid57196329897
dc.authorscopusid58250067100
dc.authorscopusid58249131800
dc.authorscopusid57724584600
dc.contributor.authorAksit M.
dc.contributor.authorColak A.
dc.contributor.authorBasok B.I.
dc.contributor.authorAksit M.Z.
dc.contributor.authorFidan M.
dc.contributor.authorKazar M.
dc.contributor.authorAltan T.K.
dc.date.accessioned2024-03-09T19:39:59Z
dc.date.available2024-03-09T19:39:59Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractObjectives: The total testing process in the laboratory is divided into pre-analytical, analytical, and post-analytical phases. Evaluating the quality of these phases and carrying out improvement studies will increase the quality of the healthcare system. In this study, we aimed to evaluate the analytical phase of the coagulation tests using the six-sigma methodology, which is a quality management tool that aims at zero error. Methods: The coefficient of variation (CV%) values were calculated from the two-level internal quality control (IQC) data between January and June 2022 of the coagulation tests (prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer). External quality control (EQC) data were retrieved from the EQC program of external quality assurance services and used in the calculation of bias %. Total allowable error (TEa) data were obtained from the database of international organizations. The sigma value for each parameter was calculated according to the formula “(TEa%–Bias %)/ CV%.” Results: Level 1 and level 2 sigma values were calculated as 4.41 and 2.93 for PT; 5.27 and 4.31 for aPTT; 2.72 and 2.73 for fibrinogen, and 4.36 and 4.08 for D-dimer. Conclusion: Among coagulation tests in which we evaluated their analytical performances using the six sigma methodology, PT (level 2) and fibrinogen (level 1 and 2) showed poor performance (sigma value <3). We decided to follow the tests with 13s /22s /R4s /41s /8x Westgard control rules. Using these tests improvement can be achieved in the analytical process, and the overall testing process may improve by performing pre-analytical, post-analytical, and analytical assessments. © 2023, Kare Publishing. All rights reserved.en_US
dc.description.sponsorshipreceived no financial support.en_US
dc.identifier.doi10.14744/ijmb.2023.09609
dc.identifier.endpage89en_US
dc.identifier.issn2587-2362
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85159267842en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage84en_US
dc.identifier.trdizinid1177824en_US
dc.identifier.urihttps://doi.org/10.14744/ijmb.2023.09609
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1177824
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1607
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKare Publishingen_US
dc.relation.ispartofInternational Journal of Medical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoagulation; quality control; six sigmaen_US
dc.titleEvaluation of analytical quality of coagulation parameters by sigmametric methodologyen_US
dc.typeArticleen_US

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