SCOLICIDAL POTENCY OF BILE AGAINST ECHINOCOCCUS GRANULOSUS

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dc.authoridAydin, Isa Caner/0000-0003-2434-0045
dc.contributor.authorAydin, Isa Caner
dc.contributor.authorIlhan, Noyan
dc.contributor.authorSeker, Ahmet
dc.contributor.authorOfluoglu, Cem Batuhan
dc.contributor.authorMulkut, Firat
dc.contributor.authorGoret, Nuri Emrah
dc.contributor.authorCetin, Kenan
dc.date.accessioned2025-03-20T09:50:36Z
dc.date.available2025-03-20T09:50:36Z
dc.date.issued2025
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractCysto-biliary fistulas are commonly diagnosed, either before or after surgical intervention, in patients with enlarged or advanced-stage hydatid cysts (HCs). Analysis of cystic contents in these patients shows that diminished scolex vitality is more common in patients with cysto-biliary fistulas. This study aims to demonstrate the scolicidal effects of bile on Echinococcus granulosus (EG) scolices at various bile concentrations and over specific periods. The time- and concentration-based scolicidal potency was analyzed in EG scolex samples obtained from HC patients. The integrity of the cyst wall and the scolicidal effect of the contents were evaluated using a vital staining technique with 0.1% eosin. Bile samples were collected from patients with cholelithiasis who were scheduled for surgery. Scolicidal efficacy of 100% was observed in all samples at the 1/4 bile concentration after 10 min and at the 1/8 concentration after 60 min. At a 1/16 concentration, scolicidal efficacy was 66% at 1 min, 89% at 10 min, 93% at 30 min, and 98% at 60 min. At a 1/32 bile concentration, scolicidal efficacy was 59% at 1 min, 68% at 10 min, 89% at 30 min, and 95% t 60 min. At a 1/64 concentration, the scolicidal efficacy was 53% at 1 min, 58% at 10 min, 77% at 30 min, and 93% at 60 min. After 1 hr, reasonable scolicidal efficacy was determined up to a 1/64 concentration; however, significant decreases in scolicidal efficacy were observed at 1/128 and 1/256 bile concentrations. Theoretically, bile, which is an endogenous secretion, can be used as a suitable and potent scolicidal agent. This study lays the groundwork for future in vivo clinical trials utilizing synthetic bile acids for scolicidal purposes or for studies evaluating the scolicidal effects of bile in patients who develop cysto-biliary fistulas.
dc.identifier.doi10.1645/24-111
dc.identifier.endpage69
dc.identifier.issn0022-3395
dc.identifier.issn1937-2345
dc.identifier.issue1
dc.identifier.pmid39937536
dc.identifier.scopus2-s2.0-85218478683
dc.identifier.scopusqualityQ3
dc.identifier.startpage64
dc.identifier.urihttps://doi.org/10.1645/24-111
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2270
dc.identifier.volume111
dc.identifier.wosWOS:001441419200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKnowledgeworks Global Ltd-Kgl
dc.relation.ispartofJournal of Parasitology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectHydatid cyst
dc.subjectBile
dc.subjectScolex
dc.subjectScolicidal agent
dc.subjectCysto-biliary fistula
dc.titleSCOLICIDAL POTENCY OF BILE AGAINST ECHINOCOCCUS GRANULOSUS
dc.typeArticle

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