Effectiveness of interventions to prevent perinatal depression: An umbrella review of systematic reviews and meta-analysis

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dc.authoridMOTRICO, EMMA/0000-0002-0720-567X
dc.authoridRodriguez-Muñoz, Maria F./0000-0002-1908-0405
dc.authoridOztekin, Deniz/0000-0002-4213-7254
dc.authoridMateus, Vera/0000-0001-8762-3056
dc.authoridKassianos, Angelos/0000-0001-6428-2623
dc.authorwosidMOTRICO, EMMA/D-2016-2019
dc.authorwosidRodriguez-Muñoz, Maria F./U-8906-2019
dc.authorwosidOztekin, Deniz/AAT-3898-2021
dc.contributor.authorMotrico, Emma
dc.contributor.authorBina, Rena
dc.contributor.authorKassianos, Angelos P.
dc.contributor.authorLe, Huynh-Nhu
dc.contributor.authorMateus, Vera
dc.contributor.authorOztekin, Deniz
dc.contributor.authorRodriguez-Munoz, Maria F.
dc.date.accessioned2024-03-09T18:48:20Z
dc.date.available2024-03-09T18:48:20Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractBackground: To date, dozens of systematic reviews (SRs) and meta-analyses (MAs) summarize the effectiveness of preventive interventions for perinatal depression. However, the results are inconclusive, making an urgent need to step up to higher levels of evidence synthesis.Aims: To summarize and compare the evidence from the SR&MA examining the effectiveness of all types of interventions for preventing perinatal depression.Method: PubMed, PsycINFO, Cochrane Database of Systematic Reviews and OpenGrey were searched from inception to December 2022. We selected SR&MA of randomized controlled trials (RCTs) that compared all types of preventive interventions for perinatal depression with control groups whose outcome was the reduction of depressive symptoms and/or incidence of new cases of perinatal depression (PROSPERO: CRD42020173125).Results: A total of 19 SRs and MAs evaluated 152 unique RCTs that included 83,408 women from 26 countries and five continents. The median effect size for any intervention was SMD = 0.29 (95% CI: 0.20 to 0.38). Ex-ercise/physical activity-based, psychological, and any type of intervention showed median effect sizes of 0.43, 0.28 and 0.36, respectively. The degree of overlap among RCTs was slight. According to AMSTAR-2, 79% of them were rated as low or critically low-quality. The strength of evidence, according to GRADE, was poorly reported and, in most cases, was low.Conclusions: Exercise/physical activity-based and psychological interventions have a small-to-medium effect on reducing perinatal depressive symptoms. There is insufficient evidence to conclude that dietary supplements and pharmacological interventions are effective in preventing perinatal depression. There is a need for high-quality SR&MA of RCTs, mainly focusing on universal preventive interventions.en_US
dc.description.sponsorshipCOST (European Cooperation in Science and Technology) [CA18138]en_US
dc.description.sponsorshipThis publication is based upon work from COST Action Research Innovation and Sustainable Pan-European Network in Peripartum Depression Disorder (Riseup-PPD), CA18138, supported by COST (European Cooperation in Science and Technology).en_US
dc.identifier.doi10.1016/j.genhosppsych.2023.03.007
dc.identifier.endpage61en_US
dc.identifier.issn0163-8343
dc.identifier.issn1873-7714
dc.identifier.pmid36958130en_US
dc.identifier.scopus2-s2.0-85150426338en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.1016/j.genhosppsych.2023.03.007
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1297
dc.identifier.volume82en_US
dc.identifier.wosWOS:000959774600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofGeneral Hospital Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPerinatal; Depression; Prevention; Randomized Control Trial; Systematic Review; Meta-Analysisen_US
dc.titleEffectiveness of interventions to prevent perinatal depression: An umbrella review of systematic reviews and meta-analysisen_US
dc.typeReview Articleen_US

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