THE EFFECT OF DIURNAL VARIATION ON LABORATORY TESTS

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dc.authoridKöseoğlu, Mehmet hicri/0000-0003-1308-6969
dc.authoridArslan, Fatma Demet/0000-0003-0766-0303
dc.authoridihtiyar, alperen halil/0000-0002-8461-4813
dc.authorwosidKöseoğlu, Mehmet hicri/HKE-2182-2023
dc.authorwosidArslan, Fatma Demet/ABG-6885-2021
dc.contributor.authorIhtiyar, Alperen Halil
dc.contributor.authorKoseoglu, Mehmet Hicri
dc.contributor.authorArslan, Fatma Demet
dc.date.accessioned2024-03-09T18:48:45Z
dc.date.available2024-03-09T18:48:45Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractPurpose: Commonly used biochemical tests in blood samples may be measured at any time of day. This study investigated the existence and clinical significance of diurnal variations in some of routine parameters to facilitate accurate and reliable decision-making in diagnosis and follow-up.Material and Methods: Blood samples were collected from 17 healthy volunteers who were 18-50 years of age (11 men, 6 women) on the same day at 9.00 am, 12.00 am, 3.00 pm, 6.00 pm, and 12.00 pm. Samples collected at 9.00 am were regarded as baseline. The results of 19 biochemical parameters in blood samples obtained at 12.00 am, 3.00 pm, 6.00 pm and 12.00 pm were statistically and clinically compared with the results at 9.00 am baseline sample.Results: Total protein, creatinine, aspartate transaminase, alanine transaminase, alkaline phosphatase and gamma glutamyl transferase showed no clinically significant variation within the day, but clinically significant changes were observed in levels of glucose, total cholesterol, HDL-cholesterol, triglyceride, total bilirubin (TBIL), direct bilirubin (DBIL), albumin, blood urea nitrogen, uric acid, sodium, potassium, chloride and amylase. Especially, BUN changed by maximum 20-30%, TBIL, DBIL and triglyceride maximum 40-50% within the day.Conclusion: The results of our study suggest that clinicians should consider the timing of blood sampling and the diurnal variations in BUN, TBIL, DBIL and triglyceride parameters during diagnosis and treatment follow-up. Sampling throughout the day seems to pose no problem for other tests with limited diurnal variation.en_US
dc.description.sponsorshipScientific Research Projects Unit of Izmir Ataturk Training and Research Hospital [47104536-799-E.10958]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Unit of Izmir Ataturk Training and Research Hospital with 47104536-799-E.10958 project numbers.en_US
dc.identifier.doi10.30621/jbachs.1122518
dc.identifier.endpage395en_US
dc.identifier.issn2458-8938
dc.identifier.issn2564-7288
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage387en_US
dc.identifier.urihttps://doi.org/10.30621/jbachs.1122518
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1459
dc.identifier.volume7en_US
dc.identifier.wosWOS:000933151700040en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDokuz Eylul Univ Inst Health Sciencesen_US
dc.relation.ispartofJournal of Basic and Clinical Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBilirubin; Blood Urea Nitrogen; Diurnal Rhythm; Triglycerideen_US
dc.titleTHE EFFECT OF DIURNAL VARIATION ON LABORATORY TESTSen_US
dc.typeArticleen_US

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