Evaluation of the Clinical Characteristics of Patients with Food Protein-Induced Enterocolitis Syndrome: A Multicenter Study

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dc.authoridKendirci, Nergiz/0000-0001-6122-5607
dc.authoridGuvenir, Hakan/0000-0001-7659-5221
dc.authorwosidGuvenir, Hakan/Y-3989-2018
dc.contributor.authorMetbulut, Azize Pinar
dc.contributor.authorOzen, Selime
dc.contributor.authorKendirci, Nergiz
dc.contributor.authorGuc, Belgin Usta
dc.contributor.authorGuvenir, Hakan
dc.contributor.authorVezir, Emine
dc.contributor.authorBahceci, Semiha
dc.date.accessioned2023-03-22T19:47:27Z
dc.date.available2023-03-22T19:47:27Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractIntroduction: Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE, cell-mediated food allergy disorder. We aimed to report the demographic characteristics, clinical features, and management of pediatric patients with FPIES. Methods: This retrospective study included all children diagnosed with FPIES at the pediatric allergy departments of the participating twelve study centers from January 2015 to November 2020. Results: A total of 73 patients (39 males, 53.4%) with a male/female ratio of 1.1 were included in the study. The median (interquartile ranges) age at symptom onset was 6 months (0.5-168, 4-9.5). The most frequent offending foods were cow's milk, egg's yolk, fish, and egg's white, identified in 38.4% (n = 28), 32.9% (n = 24), 21.9% (n = 16) and 20.5% (n = 15) of the patients, respectively. The total number of reported FPIES episodes was 290 (3.9 episodes per child). Oral food challenge (OFC) was performed in 54.8% (n = 40) of the patients, and tolerance was detected in 17 OFCs (42.5%) at a median age of 15 months (range 8-132 months). Conclusion: FPIES is a non-IgE-mediated food hypersensitivity that commonly affects infants and is often misdiagnosed. The pathophysiology of the disease remains unclear and the low awareness of FPIES among physicians and parents highlights the need for more education.en_US
dc.identifier.doi10.1159/000522496
dc.identifier.endpage813en_US
dc.identifier.issn1018-2438
dc.identifier.issn1423-0097
dc.identifier.issue8en_US
dc.identifier.pmid35661649en_US
dc.identifier.scopus2-s2.0-85132571752en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage805en_US
dc.identifier.urihttps://doi.org/10.1159/000522496
dc.identifier.urihttps://hdl.handle.net/20.500.14034/710
dc.identifier.volume183en_US
dc.identifier.wosWOS:000808296300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.journalInternational Archives Of Allergy And Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFood protein-induced enterocolitis syndromeen_US
dc.subjectFood allergyen_US
dc.subjectOral food challengeen_US
dc.subjectChildrenen_US
dc.subjectPopulationen_US
dc.subjectFishen_US
dc.subjectManagementen_US
dc.subjectChildrenen_US
dc.subjectFpiesen_US
dc.subjectMilken_US
dc.titleEvaluation of the Clinical Characteristics of Patients with Food Protein-Induced Enterocolitis Syndrome: A Multicenter Studyen_US
dc.typeArticleen_US

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