Effects of Endogen Erythropoietin on Parathormone Secretion
| dc.contributor.author | Kılıç, Esat | |
| dc.contributor.author | Gönüllü, Edip | |
| dc.contributor.author | Adanaş, Cihan | |
| dc.contributor.author | Atmaca, Murat | |
| dc.contributor.author | Özbay, Mehmet Fatih | |
| dc.contributor.author | Özkan, Sezai | |
| dc.date.accessioned | 2023-03-22T19:48:08Z | |
| dc.date.available | 2023-03-22T19:48:08Z | |
| dc.date.issued | 2021 | |
| dc.department | Belirlenecek | en_US |
| dc.description.abstract | Objective: We hypothesize that tissue hypoxia would increase erythropoietin, as well as parathormone (PTH), secretion. To verify this hypothesis, patients who had undergone orthopedic surgery with a pneumatic tourniquet were evaluated for endogenous tissue hypoxia. Methods: This study included 20 patients who underwent orthopedic surgery with a pneumatic tourniquet, wherein, 6 had diagnostic arthroscopy and 14 had anterior cruciate ligament reconstruction. All operations were performed under spinal anesthesia. The paired t-test was used to detect the differences between serial concentrations of parathyroid hormone, erythropoietin, calcium, and phosphorus levels before and after ischemia, where “p values” of <0.05 were considered significant. Results: The average duration of ischemia that patients were exposed to during surgery was 57.40±22.65 min. After ischemia, parathyroid hormone and erythropoietin levels were significantly elevated (p<0.001; p<0.001). No significant difference was found in calcium and phosphorus levels in patients before and after ischemia. A positive correlation was found between parathyroid hormone and erythropoietin levels (p<0.05). Conclusion: Our study is the first to show that the increase in erythropoietin levels in response to tissue hypoxia and increases the release of PTH | en_US |
| dc.identifier.doi | 10.4274/forbes.galenos.2021.33043 | |
| dc.identifier.endpage | 174 | en_US |
| dc.identifier.issn | 2717-9443 | |
| dc.identifier.issn | 2757-5241 | |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.startpage | 171 | en_US |
| dc.identifier.trdizinid | 516415 | en_US |
| dc.identifier.uri | https://doi.org/10.4274/forbes.galenos.2021.33043 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/516415 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14034/993 | |
| dc.identifier.volume | 2 | en_US |
| dc.indekslendigikaynak | TR-Dizin | en_US |
| dc.language.iso | en | en_US |
| dc.relation.journal | Forbes tıp dergisi (Online) | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Effects of Endogen Erythropoietin on Parathormone Secretion | en_US |
| dc.type | Article | en_US |
