Attention-guided deep learning for gestational age prediction using fetal brain MRI
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Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nature Research
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Magnetic resonance imaging offers unrivaled visualization of the fetal brain, forming the basis for establishing age-specific morphologic milestones. However, gauging age-appropriate neural development remains a difficult task due to the constantly changing appearance of the fetal brain, variable image quality, and frequent motion artifacts. Here we present an end-to-end, attention-guided deep learning model that predicts gestational age with R2 score of 0.945, mean absolute error of 6.7 days, and concordance correlation coefficient of 0.970. The convolutional neural network was trained on a heterogeneous dataset of 741 developmentally normal fetal brain images ranging from 19 to 39 weeks in gestational age. We also demonstrate model performance and generalizability using independent datasets from four academic institutions across the U.S. and Turkey with R2 scores of 0.81–0.90 after minimal fine-tuning. The proposed regression algorithm provides an automated machine-enabled tool with the potential to better characterize in utero neurodevelopment and guide real-time gestational age estimation after the first trimester. © 2022, The Author(s).
Açıklama
Anahtar Kelimeler
artifact, brain, diagnostic imaging, female, fetus, gestational age, growth, development and aging, human, image processing, information processing, neuroimaging, nuclear magnetic resonance imaging, physiology, pregnancy, procedures, turkey (bird), United States, Artifacts, Brain, Datasets as Topic, Deep Learning, Female, Fetus, Gestational Age, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Neuroimaging, Pregnancy, Pregnancy Trimesters, Turkey, United States
