The relationship between thyroid transcription factor-1 positivity and epidermal growth factor receptor mutation in lung adenocarcinoma and its prognostic significance

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dc.contributor.authorKatgi, Nuran
dc.contributor.authorCimen, Pinar
dc.contributor.authorAkyol, Murat
dc.contributor.authorAguloglu, Nursin
dc.date.accessioned2024-03-09T18:48:43Z
dc.date.available2024-03-09T18:48:43Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractBACKGROUND AND AIM: Thyroid transcription factor-1 (TTF-1) is a good prognostic factor and is also thought to be associated with driver mutations in lung cancer. This study aimed to evaluate the relationship between TTF-1 expression and prognosis and driver mutations in lung adenocarcinomas.METHODS: We analyzed the data of 307 patients who were diagnosed with lung adenocarci-noma and underwent TTF-1 testing in two centers between January 2018 and January 2021. RESULTS: Of the 307 patients included in the study, 231 were TTF-1 positive, 23 were weakly positive, and 53 were negative. There was no statistically significant relationship between TTF-1 positivity and progression-free survival (PFS) (p=0.492). However, overall survival (OS) was significantly longer in TTF-1 positive patients (p=0.005). Both PFS and OS were sig-nificantly longer in TTF-1 positive patients with multiple metastates (p=0.001, p=0.013). Of the 199 patients who underwent epidermal growth factor receptor (EGFR) mutation analysis, EGFR positivity was detected in 62 of them, and 58 patients were found to be in the TTF-1 positive group (p=0.022). CONCLUSIONS: Thyroid transcription factor-1 positivity in lung adenocarcinomas is a good prognostic factor that often accompanies EGFR positivity.en_US
dc.identifier.doi10.14744/ejp.2022.1204
dc.identifier.endpage140en_US
dc.identifier.issn2148-3620
dc.identifier.issn2148-5402
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://doi.org/10.14744/ejp.2022.1204
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1428
dc.identifier.volume25en_US
dc.identifier.wosWOS:001050294700008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofEurasian Journal of Pulmonologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpidermal Growth Factor Receptor (Egfr); Lung Adenocarcinoma; Prognosis; Thyroid Transcription Factor-1 (Ttf-1)en_US
dc.titleThe relationship between thyroid transcription factor-1 positivity and epidermal growth factor receptor mutation in lung adenocarcinoma and its prognostic significanceen_US
dc.typeArticleen_US

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