Yazar "Tekin, Hande Gazeteci" seçeneğine göre listele
Listeleniyor 1 - 12 / 12
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Clinical and Electrophysiological Features Predicting Response to Antiseizure Medications in Juvenile Absence Epilepsy(Georg Thieme Verlag Kg, 2023) Karaoglu, Pakize; Tekin, Hande GazeteciBackground We aimed to evaluate the clinical findings and electroencephalographic (EEG) characteristics of patients with juvenile absence epilepsy (JAE) and to determine the factors that predict response to antiseizure medications (ASMs) in JAE. Methods We reviewed the medical records of 29 patients with JAE. The patients who were seizure-free during the last 12 months of their follow-up and who did not have generalized spike waves on their last EEG were considered as the treatment-responsive group, and the patients whose clinical seizures persisted during the last 12 months of their follow-up or who had generalized spike waves on their follow-up EEGs were considered as patients who did not respond to ASMs. Results There were 29 patients, 20 girls and nine boys, with a mean age of 13.34 +/- 2.17 years and a follow-up time of 32.1 +/- 11.9 months. Twenty-two cases (75.8%) were evaluated as responsive to treatment. Generalized tonic-clonic seizures (GTCS) were statistically more common in patients who did not respond to ASM. Epileptic seizures began at a younger age in the group that responded to medication. Occipital intermittent rhythmic delta activity (OIRDA) in EEG was significantly higher in the group that responded to the medication. Conclusion Our study shows that concomitant GTCS may predict poorer response to ASMs in JAE. Younger age at diagnosis and OIRDA on EEG may be associated with better response to treatment. Our findings need to be confirmed by further prospective and long-term studies.Öğe Clinical and Electrophysiological Prognostic Factors of Childhood Absence Epilepsy(Galenos Yayincilik, 2021) Tekin, Hande Gazeteci; Karaoglu, Pakize; Edem, PinarAim: Childhood absence epilepsy is common idiopathic epilepsy in childhood. This epilepsy, which has been shown to impair cognition, needs to be treated promptly and correctly. Therefore, determining its prognostic factors before treatment can provide prediction on the duration of treatment, drug selection, and drug dosage. Materials and Methods: The electroencephalography (EEG) and clinical findings of patients diagnosed with childhood absence epilepsy who were monitored for at least 12 months in the pediatric neurology clinics of two university hospitals between 2016 and 2020 were reviewed retrospectively. The patients were divided into two groups as responsive and unresponsive, according to seizures, EEG findings, and recurrent seizures after treatment. The epidemiological and clinical features of the two groups were compared. Results: Sixty-three patients who were diagnosed with childhood absence epilepsy according to the Panayiotopoulos criteria participated in this study. Thirty-nine (62%) of the patients were responsive to treatment (group 1), the remaining 24 patients (38%) (group 2) were unresponsive to treatment. Fifteen patients were valproate resistant, and nine patients relapsed after drug treatment withdrawal in group 2. The mean age of the patients was 7.87 +/- 1.68. The mean follow-up period was 29.1 +/- 13.6 (13-72 months) months. The mean age was tower in the responsive group of patients. The time between the onset of seizures and treatment was significantly longer in group 2. The number of patients with occipital intermittent rhythmic delta activity (OIRDA) in the responsive group was higher. A significant difference was found in the number of spike-slow wave complex and the amplitude of discharges between the two groups. Conclusion: In this study, it was seen that young age was an advantage for treatment response. Early initiation of treatment and OIRDA were good prognostic factors, while high amplitude and numerous discharges were among the poor prognostic factors.Öğe Clinical and electrophysiological prognostic factors of childhood absence epilepsy(Galenos Yayincilik, 2021) Tekin, Hande Gazeteci; Karaoğlu, Pakize; Edem, PınarAim: Childhood absence epilepsy is common idiopathic epilepsy in childhood. This epilepsy, which has been shown to impair cognition, needs to be treated promptly and correctly. Therefore, determining its prognostic factors before treatment can provide prediction on the duration of treatment, drug selection, and drug dosage. Materials and Methods: The electroencephalography (EEG) and clinical findings of patients diagnosed with childhood absence epilepsy who were monitored for at least 12 months in the pediatric neurology clinics of two university hospitals between 2016 and 2020 were reviewed retrospectively. The patients were divided into two groups as responsive and unresponsive, according to seizures, EEG findings, and recurrent seizures after treatment. The epidemiological and clinical features of the two groups were compared. Results: Sixty-three patients who were diagnosed with childhood absence epilepsy according to the Panayiotopoulos criteria participated in this study. Thirty-nine (62%) of the patients were responsive to treatment (group 1), the remaining 24 patients (38%) (group 2) were unresponsive to treatment. Fifteen patients were valproate resistant, and nine patients relapsed after drug treatment withdrawal in group 2. The mean age of the patients was 7.87 +/- 1.68. The mean follow-up period was 29.1 +/- 13.6 (13-72 months) months. The mean age was lower in the responsive group of patients. The time between the onset of seizures and treatment was significantly longer in group 2. The number of patients with occipital intermittent rhythmic delta activity (OIRDA) in the responsive group was higher. A significant difference was found in the number of spike-slow wave complex and the amplitude of discharges between the two groups. Conclusion: In this study, it was seen that young age was an advantage for treatment response. Early initiation of treatment and OIRDA were good prognostic factors, while high amplitude and numerous discharges were among the poor prognostic factors.Öğe Clinical and genetic evaluations of rare childhood epilepsies in Turkey's national cohort(Wiley, 2023) Unalp, Aycan; Guzin, Yigithan; Unay, Bulent; Tosun, Ayse; Cavusoglu, Dilek; Tekin, Hande Gazeteci; Kurul, Semra HizObjective: As new-generation sequencing methods develop, rare epilepsy is increasing and burdening national health systems-community building among rare epilepsies fuels collaboration, research, and resource development. Comorbidities should be carefully considered in diagnosing and treating children with rare epilepsy. This multicentric study aimed to evaluate the clinical features and comorbidities of children diagnosed with rare childhood genetic epilepsies. Methods: This multicentric study evaluated demographics, clinical findings, neuromotor developmental progress, and concomitant comorbid diseases of childhood rare genetic epilepsies. We included 156 patients from the nine tertiary health centers in our research. Results: The gene variants were distributed to 36 patients (23.1%) with SCN1A, 14 (9%) with KCNQ2, 10 (6.4%) with PCDH19, 6 (3.8%) with SCN8A, 5 (3.2%) with SLC2A1, 5 (3.2%) with WWOX, respectively. The remaining 80 patients (51.3%) were with other gene variants. Comorbid conditions are present in 82% of patients, most commonly intellectual disability (70%), developmental delay (32.1%), and movement disorders 12.8%. Most of the rare genetic epileptic children (52%) were using more than three anti-seizure drugs. In terms of developmental delay in children with rare epilepsy, the neuromotor developmental delay was found to progress with age, shown at the end of 2nd year of treatment. In addition, comorbidity, number of drugs, multiple types of seizures, seizure frequency, age at diagnosis of epilepsy, and duration of epilepsy all affected neuromotor developmental status (p <.05). Significance: Despite using multiple antiseizure medications, most of our patients had drug-resistant epilepsy and concomitant developmental delay. Since a complete cure cannot be achieved in most of these patients further studies with centers' collaboration might help improve therapeutic decisions and precision treatment methods.Öğe Deprem sonrası göç eden ergenlerde gerilim tipi baş ağrısı: Kontrollü çalışma(2021) Gönüllü, Edip; Tekin, Hande GazeteciGiriş: Depremzedeler afetlerin akut travmatik etkilerinin yanı sıra aile bireylerini kaybetmek, ikamet ettikleri yeriterk etmek zorunda kalmak, okul değiştirmek gibi ciddi psikolojik stresli durumlarla da karşı karşıya kalmaktadırlar.Doğal afetler sonrası gelişen hastalıklar arasında gerilim tipi baş ağrısı travma sonrası stres bozukluğundan sonraen sık görülen ikinci durumdur.Gereç ve Yöntem: Bu çalışma gerilim tipi baş ağrısı açısından deprem sonrası yer değiştirmek zorunda kalan(Grup 1), deprem geçirip yer değiştirmeyen (Grup 2) ve yıkıma neden olacak bir deprem yaşamamış ergenlerde(Kontrol Grup) yürütüldü. Tüm hasta gruplarının epidemiyolojik ve demografik özellikleri kaydedildi. Baş ağrısıolan hastalar, baş ağrısı nedeniyle okula gelememe, okul ödevlerini yapamama, ev işlerine yardım etme gibigünlük aktiviteleri açısından sorgulandı ve kayıt altına alındı. Grupların karşılaştırılmasında Student's t testi ve kikare testi kullanıldı. P <0.05 değeri istatistiksel olarak anlamlı kabul edildi.Bulgular: 498 lise öğrencisinin yaş ortalaması 15.6 ± 0.67 olup, bu öğrencilerin 287'si erkek, 211'i kızdır. Afetsonrası yerinden olan ergenlerde gerilim tipi baş ağrısı oranı % 64, deprem sonrası göç etmeyen ve bulunduğuyerde kalanlarda ise bu oran % 40 idi. Gerilim tipi baş ağrısı olan Grup 1'deki hastaların% 38,6'sının baş ağrısışiddet skoru yüksek (4-5 puan) olmakla birlikte bu bulgu istatistiksel olarak anlamsızdı. Doksan gün okulagelmeme ve ev işlerine yardımda aksama bakımından karşılaştırıldığında üç grup arasında anlamlı fark bulundu.Sonuç: Depreme maruz kalan ve yerinden edilmiş ergenlerde baş ağrısı sıklığının ve şiddetinin diğer gruplaragöre daha yüksek olması, bu grubun deprem bölgesinden uzaklaşmalarına rağÖğe Effects of sulthiame on seizure frequency and EEG in children with electrical status epilepticus during slow sleep(Academic Press Inc Elsevier Science, 2021) Topcu, Yasemin; Kılıç, Betül; Tekin, Hande Gazeteci; Aydın, Kürşad; Turanlı, GüzideObjective: It is argued that early and adequate treatment of electrical status epilepticus in sleep (ESES) is essential to preserve cognitive functions and possibly recovering lost skills. Although antiepileptic drugs (AEDs) are effective in ESES, there is not much experience in the use of sulthiame. In this study, we aimed to examine the efficiency and tolerability of sulthiame in ESES. Methods: The data of 39 patients diagnosed as ESES and who received sulthiame as an additional treatment between 2016 and 2020 were reviewed retrospectively. Electroencephalographic (EEG) findings and seizure rates were compared before and after the sulthiame treatment. Results: The mean age was 8.5 +/- 4.1 (1.5-16 years). Nine out of 39 patients had benign childhood focal epilepsies. Structural causes were identified in 13 patients. The mean duration of sulthiame use was 32.5 +/- 13.7 months. After sulthiame treatment, 25 patients (64.1%) were seizure free, and 8 (20.5%) had more than a 50% decrease in seizure frequency. The mean seizure-free time after the sulthiame treatment was 27.8 +/- 17.9 months. Nineteen patients (48.7%) had complete, and nine patients (23.1%) had partial EEG improvement. Complete seizure control was significantly higher in benign focal epilepsy of childhood (p = 0.01). Significant neurocognitive and behavioral recovery, improvement in school performance was observed following sulthiame treatment (p < 0.001). Conclusion: Sulthiame was found to be effective in seizure control and EEG improvement in ESES. We think that the use of sulthiame alone can be a good choice with high efficacy and tolerability in ESES. (C) 2021 Elsevier Inc. All rights reserved.Öğe Evaluation of MicroRNAs in Pediatric Epilepsy(Aves, 2023) Carman, Kursat Bora; Tekin, Hande Gazeteci; Cavusoglu, Dilek; Yarar, Coskun; Kaplan, Emre; Karademir, Cefa Nil; Arslantas, DidemObjective: The pathophysiology of epilepsy remains unknown. Recent research has shown that microRNA expression changes in epileptic adults. In the present work, we aimed to identify serum microRNA expression in drug-responsive and resistant children with idiopathic generalized epilepsy.Materials and Methods: The study included 43 (20 male and 23 female) epilepsy patients and 66 (43 male and 23 female) control subjects. The mean ages of the groups were 113.41 & PLUSMN; 61.83 and 105.46 & PLUSMN; 62.31 months, respectively. Twenty-eight epileptic patients were classified as drug resistant. Thirteen of the controls were the siblings of patients with epilepsy. The study only included children with idiopathic generalized epilepsy who had normal brain magnetic resonance imaging. The serum microRNA expressions (microRNA-181a, microRNA-155, microRNA-146, and microRNA-223) were investigated. Expressions of serum microRNA-181a, microRNA-155, microRNA-146, and microRNA-223 were previously investigated in epilepsy patients and children with febrile seizures. Therefore, these microRNAs were chosen. The expressions of serum levels of microRNAs were determined using quantitative real-time polymerase chain reaction.Results: The results indicated that the expressions of serum microRNA-155 and microRNA-223 were elevated in epileptic children (P < .05). The expression of the same microRNAs was also elevated in individuals with drug-resistant epilepsy compared to healthy controls (P < .05). microRNA-146a, microRNA-155, and microRNA-223 expressions were higher in drug-resistant patients than in drug-responsive children (P < .05). A logistic regression study determined that an increase of microRNA-155 was a risk for epilepsy, while a decrease of microRNA-146a risk for epilepsy.Conclusion: Few researchers have investigated the function of microRNAs in the development of childhood epilepsy. Our findings revealed that epilepsy patients have abnormal microRNAexpression.Öğe Evaluation of the Effect of Parenting Style and Parental Mealtime Actions on the Eating Behavior of Children with Epilepsy(MDPI, 2024) Balci, Tutku; Bicer, Nihan Cakir; Tekin, Hande Gazeteci; Edem, PinarBackground: Research on the interaction of parenting style, parents' mealtime behaviors, and children's eating behavior in the presence of chronic disease is limited. This study aimed to investigate the impact of parenting style and parental mealtime actions on the eating behavior of children with epilepsy. Methods: Thirty-one children with epilepsy, thirty-one healthy children (aged 4-9 years), and their parents were included. The Multidimensional Assessment of Parenting Scale (MAPS), Parent Mealtime Action Scale, Children's Eating Behavior Questionnaire, and Healthy Eating Index (HEI)-2015 were applied. The MAPS, HEI-2015 scores, and body mass index for age Z scores were similar in both groups (p > 0.05). In the epilepsy group, the food approach behavior score was higher, and positive correlations were noted between broadband negative parenting and food approach behavior, and the HEI-2015 score and broadband positive parenting (p < 0.05). Regression analysis showed that broadband negative parenting and snack modeling increased the food approach behavior in the epilepsy group. Owing to the chronic disease, the effects of parent-child interaction on the child's eating behavior in the epilepsy group differed from those of healthy children reported in the literature.Öğe Long term outcome in obstetric brachial plexus injury at a tertiary care center(Selçuk BAŞAK, 2022) Tekin, Hande Gazeteci; Olukman, ÖzgürBackground/Aim: Obstetric brachial plexus injury (OBPI) is caused by traction to the brachial plexus during labor. Traction injury may vary from neurapraxia or axonotmesis to neurotmesis and can cause edema, avulsion, or rupture of the nerve. Improvement in the first two weeks after birth is a good indicator of outcome. The disability varies according to the location and severity of the effect in the plexus. However, most injuries are transient, with a total return of function in many cases. This study aimed to obtain clues for the prevention and follow-up of obstetric brachial plexus injuries by revealing the outcome and clinical features. Methods: In this retrospective cohort study, hospital records of patients with brachial plexus injury due to delivery were reviewed between January 2017 and September 2021. Injury levels, birth weights, other injuries at birth, maternal age, gravidity, gestation time, and treatment response were recorded. Brachial plexus injuries of the patients were classified per the NARAKAS classification. The Spearman correlation and Pearson correlation tests were used for correlation analyses. The variables were evaluated with the Chi-Square and Student's t-tests. The normality of the distribution was assessed with the Kolmogorov-Smirnov test. A value of PÖğe Neuronal ceroid lipofuscinosis: genetic and phenotypic spectrum of 14 patients from Turkey(Springer-Verlag Italia Srl, 2021) Kose, Melis; Kose, Engin; Ünalp, Aycan; Yılmaz Unsal; Edizer, Selvinaz; Tekin, Hande Gazeteci; Yıldırım, Eser SozmenIntroduction and purpose Neuronal ceroid lipofuscinoses (NCLs) is a group of congenital metabolic diseases where the neurodegenerative process with the accumulation of ceroid and lipofuscin autofluorescent storage materials is at the forefront. According to the age of presentation, NCLs are classified as congenital, infantile (INCL), late infantile (LINCL), juvenile (JNCL), and adult (ANCL) NCLs. In our study, it was aimed to discuss the clinical and molecular characteristics of our patients diagnosed with NCL. Material and method This is a descriptive cross-sectional study which was conducted in 14 patients from 10 unrelated families who were diagnosed with different types of NCL based on clinical presentation, neuroimaging, biochemical measurements, and molecular analyses, at the department of pediatric metabolism between June 2015 and June 2020. Results A total of 14 patients were diagnosed with different types of NCL. Of those, 4 patients were diagnosed with NCL7 (4/14; 30%), 3/14 (23%) with NCL1, 3/14 (23%) with NCL2, 2/14 (14.2%) with NCL13, and 1/14 (7.1%) with NCL10. Eleven pathogenic variants were detected, 5 of which are novel (c.721G>T [p.Gly241Ter] and c.301G>C [p.Ala146Pro] in MFDS8 gene; c.316C>T [p.Gln106Ter] in PPT1 gene; c.341C>T [p.Ala114Val] in TPP1 gene; c.686A>T [p.Glu229Val] in CTSD gene) Conclusion This study is one of the pioneer comprehensive researches from Turkey that provides information about disease-causing variants and clinical presentation of different and rare types of NCLs. The identification of novel variants and phenotypic expansion is important for genetic counselling in Turkey and expected to improve understanding of NCLs.Öğe Spinal muscular atrophy with predominant lower extremity (SMA-LED) with no signs other than pure motor symptoms at the intersection of multiple overlap syndrome(Elsevier, 2022) Tekin, Hande Gazeteci; Edem, Pinar; Ozyilmaz, BerkBackground: Mutations in the cytoplasmic dynein 1 heavy chain gene (DYNC1H1) have been associated with spinal muscular atrophy with predominant lower extremity involvement (SMA-LED), Charcot-Marie-Tooth 2O (CMT2O) disease, cortical migration anomalies, and autosomal dominant mental retardation13. SMA-LED phenotype-related mutation was found in the DYNC1H1 gene in the patient who applied with the complaint of gait disturbance.Methods: Pathogenic heterozygous c.1678G > A (p.Val560Met) mutation was detected in the DYNC1H1 gene by next generation targeted gene analysis in the patient who had no phenotypic findings except delayed motor milestones, lumbar lordosis, and lower extremity muscle weakness. The patient's creatinine phosphokinase enzyme level and brain magnetic resonance imaging (MRI) were normal. Electromyography (EMG) had pure motor findings.Conclusion: It should be kept in mind that DYNC1H1 mutation, which we are accustomed to seeing with accompanying findings such as orthopedic and ocular dysmorphic findings, sensorineural EMG findings, and intellectual disability, can also observe with pure motor findings such as muscular dystrophy examination findings. (c) 2021 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.Öğe Video game exposure in children with epilepsy: EEG and clinical findings(Elsevier, 2025) Tekin, Hande Gazeteci; Edem, PinarObjective: To investigate the effects of video game exposure on pediatric epilepsy patients, focusing on electroencephalography (EEG) and clinical outcomes. Methods: A total of 94 pediatric epilepsy patients aged 6-18 years (juvenile idiopathic generalized epilepsy, childhood absence epilepsy, self-limited idiopathic focal epilepsy [SeLEAS and SeLECTS]) and 57 non-epileptic controls were enrolled. EEG recordings were obtained while patients were awake, asleep, and during video game play. The impact of video games was analyzed across different epilepsy subgroups and according to epilepsy control status. Results: Twenty-five patients with EEG deterioration in the entire group, three of whom were from the control group (p = 0.032). Among juvenile idiopathic generalized epilepsy patients, 2 of 21 controlled and 6 of 11 uncontrolled patients were adversely affected by video games (p = 0.01). In the SeLECTS group, none of the controlled patients and 3 of 11 uncontrolled patients showed adverse effects (p = 0.063). In the absence epilepsy and SeLEAS groups, epilepsy status did not significantly affect video game response (p = 0.250, p = 0.603). Patients with pattern sensitivity and photosensitivity had a higher risk of EEG deterioration during video game play than those without these sensitivities. Conclusions: Playing selected video games is safer for patients with juvenile idiopathic generalized epilepsies and the SeLECTS group when precautions are taken, and both EEG and clinical conditions are under control. However, video games pose a risk for patients with absence epilepsy and SeLEAS, regardless of epilepsy control status. These findings underscore the need for individualized assessments and tailored recommendations for video game exposure in pediatric epilepsy patients.
