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    Assessment of mimicking by EBV-CMV immunoglobulin M of anti-HLA antibodies
    (Elsevier, 2023) Gulec, Rasime Derya; Arslan, Fatma Demet; Ozyilmaz, Berk; Yilmaz, Nisel; Hanci, Sevgi Yilmaz; Kose, Sukran
    Objective: We aimed to show the cross-reactivity that may occur between immunoglobulin (Ig) M antibodies that form against Cytomegalovirus (CMV) and/or Epstein-Barr virus (EBV) and human leukocyte antigens (HLA).Methods: Complement-dependent cytotoxicity (CDC) cross-reactivity between serum samples of 57 patients with IgM positive CMV and/or EBV infections and T and B cells from 15 healthy donors were evaluated. Dithiothreitol was used to distinguish cross-reactivity caused by IgM antibodies from IgG.Results: The cross-reactivity ratio between pathogenic IgM antibodies with T cell of the 12th donor, and B cell of the 3rd, 4th, and 8th donors was significantly higher (p = 0.011, <0.001, <0.001 and 0.013, respectively). The ratio of B cell CDC cross-reactivity of all donors (26.4%) was higher than the ratio of T cell CDC cross-reactivity (5.2%) (p < 0.001). The ratio of T cell CDC cross-reactivity of sera containing both anti-CMV IgM and anti-EBV IgM antibodies was significantly higher than those of sera containing only anti-CMV IgM or only anti-EBV IgM antibodies (p = 0.002 and p < 0.001, respectively). There was no difference between B cell CDC cross-reactivity rates according to the presence of anti-CMV and/or anti-EBV IgM antibodies.Conclusion: Cross-reactivity may occur between anti-CMV and anti-EBV IgM antibodies with HLA molecules. Thus, in graft recipients, pathogenic IgMs can also act as de novo anti-HLA antibodies and aggravate the rejection process.
  • Küçük Resim Yok
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    Covid-19 vaccination acceptance and hesitancy among the Turkish adult population
    (German Medical Science-Gms, 2023) Kose, Sukran; Mandiracioglu, Aliye; Ozbel, Yusuf; Zeyrek, Seheray; Akdeniz, Didem Dereli; Kafil, Hossein Samadi
    Objective: The aim of this study was to determine the acceptance of Covid-19 vaccine among the Turkish adult population. Methods: A total of 2023 persons participated in this cross-sectional study between October 2020 and January 2021. The questionnaire, which was delivered via social media, was filled out by the participants over Google Forms. Results: Questionnaire results showed that 68.7% of the participants might agree to vaccinated against COVID-19. According to univariate analysis, the age group of 50-59, urban residents, healthcare workers, non-smokers, and those with chronic diseases, those who were vacci-nated against influenza, pneumonia, and tetanus were all willing to be vaccinated against COVID-19. Conclusions: It is very important to determine a community's willingness to be vaccinated against COVID-19 so that interventions can be made to solve related problems. Risk of exposure and importance of Preven-tion play a critical role in vaccination acceptance.
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    Effect of Colchicine on Secondary Acute Lung Injury in an Experimental Sepsis Model in Rats
    (Galenos Publ House, 2023) Ceylan, Mehmet; Kose, Sukran; Yilmaz, Hueseyin Oguz; Aktas, Safiye; Yilmaz, Osman
    Introduction: An irregular systemic inflammatory response in sepsis can induce acute lung injury (ALI), which is characterized by the exaggerated inflammation of the lung tissue. Colchicine inhibits several inflammatory pathways which may prevent sepsis-induced secondary lung injury. We aimed to examine the histopathological effects of colchicine on lung tissue in a lipopolysaccharide (LPS)-induced sepsis model in rats.Materials and Methods: Twenty-eight rats were randomly divided into the following four groups: sham (n=6), colchicine only (n=6), sepsis only (n=8) and sepsis+colchicine (n=8). In the sham group, 0.9% NaCl was administered intraperitoneally (IP) and intragastrically (IG). In the Colchicine only group, 0.9% NaCl was administered IP and colchicine was administered IG. Sepsis was induced in the sepsis only and sepsis+colchicine groups by administering of 1 mg/kg of LPS IP at the 0-time point. In the sepsis+colchicine group, colchicine was additionally given IG at the 90th minute. An observational sepsis scoring system was used to evaluate the signs of sepsis. Subsequently, the rats were sacrificed at the 24th hour. The lung tissues were examined according to the American Thorax Association's assessment report on ALI in animals.Results: The histopathological lung injury score in the sepsis+colchicine group was significantly higher than in the sham group (0.23 +/- 0.18 vs. 0 +/- 0; p<0.05) and was significantly lower than in the sepsis only group (0.23 +/- 0.18 vs. 0.57 +/- 0.14; p<0.001). Evaluation of the lung damage score revealed that colchicine suppressed the increase in alveolar and interstitial neutrophil counts and limited the increase in hyaline membrane counts and alveolar wall thickness in the sepsis+colchicine group when compared with the sepsis only group.Conclusion: In our experimental sepsis rat model, administration of colchicine for sepsis limited the secondary lung damage.