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Öğe Akut serebrovasküler olay geçiren hastalarda acef risk skoru ile aritmi gelişimi arasındaki ilişki(2022) Güzel, Tuncay; Kış, Mehmet; Şenöz, OktayGiriş: Akut inmeden sonra yüksek riskli hastaların belirlenmesi, uygun kardiyak izlem ve altta yatan aritmilerin tanı ve tedavisi, kardiyak morbidite ve mortaliteyi önlemek için önemlidir. ACEF risk skoru, sadece kısa ve uzun vadeli mortalite açısından değil, aynı zamanda majör advers kardiyovasküler olaylar açısından da tatmin edici prediktif değerler ile ilişkilendirilmiştir. Bu çalışmanın amacı akut iskemik serebrovasküler olay (SVO) geçiren hastalarda ACEF risk skoru ile aritmi gelişimi arasındaki ilişkinin araştırılmasıdır. Gereç ve Yöntem: Çalışmaya, akut iskemik SVO geçiren, bazal elektrokardiyografisinde (EKG) aritmi bulunmayan ve aritmi tespiti için Holter EKG takılan ardışık 158 hasta dahil edilmiştir. Hastalar, Holter EKG’de aritmi saptanmayanlar (Grup 1) ve saptananlar (Grup 2) şeklinde iki gruba ayrılarak incelendi. ACEF skoru aşağıdaki formüle göre hesaplandı; ACEF = yaş/sol ventrikül ejeksiyon fraksiyonu+1 (kreatinin>2.0 mg/dL ise). Bulgular: Hastaların yaş ortalaması 71.6±10.6 yıldı ve grup II'deki yaş ortalaması grup I'e göre istatistiksel olarak anlamlı derecede yüksekti (72.8±10.1'e karşı 68.8±11.2 yıl, p=0.025). Hastaların 110'unda (%69.6) Holter EKG'de aritmi saptandı. En sık görülen aritmi tipi ventriküler ekstrasistoller (%32.7) idi. Ortalama ACEF skoru 1.43±0.49 olarak bulundu. ACEF risk skoru grup II'de grup I'e göre istatistiksel olarak anlamlı derecede daha yüksekti (1.497±0.511'e karşı 1.285±0.407, p=0.012). ACEF risk skoru değeri >1.26, %59 duyarlılık ve %56 özgüllük ile akut iskemik inmeli hastalarda aritmi için bir öngördürücü olarak saptandı (eğri altındaki ROC alanı: 0.642, %95 CI: 0.548-0.737, P =0.004 ). Sonuç: Akut iskemik SVO geçiren hastalarda yüksek ACEF risk skoru, holter EKG ile tespit edilen, altta yatan aritmi varlığı ile ilişkilidir. Bu hastalarda aritmi varlığını öngörmek için basit ve kolay ulaşılabilir ACEF risk skoru kullanılabilir.Öğe The relationship between good collateral development and magnesium/phosphate ratios in chronic total occlusion(2022) Kış, Mehmet; Şenöz, Oktay; Güzel, TuncayObjective: Coronary collateral formation can be triggered by many acquired factors such as ischemia and growth factors, which ultimately manifests as differences in the quality of the coronary collateral circulation (CCC) in patients. Low magnesium (Mg) levels can increase endothelial cell dysfunction and potentially increase the risk of thrombosis and atherosclerosis. However, it has been reported that high serum phosphate (P) levels are correlated with the development of atherosclerosis and mortality. In this article, we aimed to reveal the relationship between CCC quality and Mg/P ratio in chronic total occlusion (CTO). Methods: A total of 269 patients with detected CTO in coronary angiography between March 2014 and June 2018 were included in the study. The patients were divided into two groups as group I (127 patients) and group II (142 patients) according to the Rentrop classification. The study is a retrospective, observational study. Results: In the multivariable regression analysis; smoking (p=0.004), triglyceride (p<0.001) and Mg/P ratio (p<0.001) parameters were independent predictors affecting CCC in CTO. Mg/P value was statistically lower in the group I (0.49±0.17) than group II (0.62±0.12) (p<0.001). The ideal Mg/P cut-off value was 0.56 that calculated by the Youden index had 69% sensitivity, and 64% specificity for collateral development of CTO. Conclusion: Mg/P is a parameter that affects coronary collateral development. High Mg/P ratio level is associated with good collateral development in patients who had CTO.Öğe The relationship between left ventricular diastolic dysfunction and hemoglobin A1c levels in the type 2 diabetes mellitus patient population(2022) Şenöz, Oktay; Güzel, Tuncay; Kış, MehmetObjectives: This study aimed to investigate the relationship between hemoglobin A1c (HbA1c) levels, which is a good marker for determining glycemic levels, and left ventricular diastolic dysfunction (LVDD) in the type 2 diabetes mellitus (DM) patient population. Patients and methods: This retrospective study was conducted with 116 type 2 DM patients (62 males, 54 females; mean age: 58.4±9.5 years; range, 18 to 65 years) between July 2019 and November 2021. The patients were divided into two groups as those without LVDD (n=55, Group 1) and those with LVDD (n=61, Group 2). Early to late diastolic transmural flow velocity (E/A) ratio, the mean ratio (E/e') of mitral inflow (E) and mitral annular (e'), HbA1c levels, other hemogram and biochemical parameters, and demographic data were recorded. Results: The HbA1c level was significantly higher in the group with LVDD (6.96±1.23 vs. 9.00±2.19, p<0.001). While the mean E/e' ratio was 9.69±2.73 in the group without LVDD, it was 16.00±1.69 in the group with LVDD, and there was a significant difference between the two groups (p<0.001). The mean E/A ratio was significantly higher in the group without LVDD (1.25±0.51 vs. 1.02±0.53, p=0.021). In regression operating characteristics analysis, a HbA1c cut-off value of 7.35 and was found to be a predictor of LVDD in the type 2 DM patient group with a sensitivity of 80% and specificity of 80% (AUC: 0.805; 95% confidence interval: 0.718-0.892; p<0.001). Conclusion: Providing close glycemic follow-up and monitoring the HbA1c level can reduce heart failure and other comorbid conditions that may develop, particularly after LVDD.
