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    Comparison of national early warning score 2 and quick sepsis-related organ failure assessment score in predicting severe coronavirus disease 2019: A validation study
    (Kare Publ, 2022) Güçsav, Mutlu Onur; Alıcı, İbrahim Onur; Kömürcüoğlu, Berna
    BACKGROUND AND AIM: Coronavirus disease 2019 (COVID-19) has imposed a heavy burden on the intensive care unit and health care systems worldwide. Therefore, early detection of high-risk patients in terms of poor prognosis is crucial. We aimed to compare the diagnostic yield of the two most reliable scoring systems (National Early Warning Score 2 [NEWS 2] and quick Sepsis-related Organ Failure Assessment [qSOFA]) when repeatedly performed during the COVID-19 course. METHODS: The data of 403 COVID-19 patients admitted to our hospital between March 1, 2020, and November 30, 2020, were retrospectively reviewed. The demographic, comorbidity, and clinical data of the patients were recorded in the evaluation. NEWS2 and qSOFA score were retrospectively calculated at the time of admission, 24th hour, and 48th hour. We compared the effectiveness of qSOFA and NEWS2 for predicting the prognosis of COVID-19. RESULTS: The mean NEWS2 at the time of admission, 24th hour, and 48th hour was significantly higher in patients with poor outcomes than in patients with good outcomes. The 48th-hour NEWS2 was found to be the most successful score in predicting the poor outcome (AUC: 0.854; 95% CI: 0.81-0.88; p<0.001). NEWS2 at 0th, 24th, and 48th hours were found to be superior to qSOFA scores at the same time points. CONCLUSIONS: NEWS2 was superior to qSOFA in determining the need for intensive care support and/or mortality. A high NEWS2 at the 48th hour seems to be more valuable to predict worse outcomes.
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    Is chronic respiratory disease a possible risk factor in acute pulmonary thromboembolism?
    (2022) Karadeniz, Gülistan; Erikci, İsmail; Güçsav, Mutlu Onur; Ayrancı, Aysu; Polat, Gülru; Vayısoğlu, Görkem
    Objective: Although we frequently encounter pulmonary thromboembolism (PTE) in patients with chronic respiratory disease in our daily practice, only the presence of respiratory failure is stated as a risk factor in the guideline. In our study, it was aimed to investigate the frequency of acquired risk factors, especially chronic respiratory diseases, in acute PTE. Material and Methods: Our study was designed as a single-center observational descriptive study. Patients hospitalized with the diagnosis of acute PTE in our hospital were evaluated between August 01, 2016 and August 01, 2020. Results: A total of 157 patients were included in our study. The most common acquired risk factors were; being 65 years and older (n=80, 51%), arterial hypertension (n=65, 42.4%), obesity (n=35, 22.3%) and chronic respiratory disease (n=30, %19.1). No ac quired risk factor was found in 31 patients (19.2%). Chronic obstructive lung disease (n=22, 73.3%) was the most common disease among chronic respiratory diseases. Other respiratory diseases were interstitial lung disease (n=5, 16.7%), obstructive sleep apnea syndrome (n=2, 6.7%), and asthma (n=1, 3.3%). The presence of chronic respi ratory disease was significantly higher in men, patients aged 65 and over, and smokers. Conclusion: The frequency of PTE risk factors varies according to countries and socioe conomic level. Our data showed that chronic respiratory disease is more common in PTE patients than many diseases or conditions that are currently considered as risk factors.
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    The Impact of the 2023 Kahramanmaraş (Türkiye) Earthquakes on Asthma Control in Adults: A Single Center Cross-Sectional Study
    (Turkiye Klinikleri, 2024) Güçsav, Mutlu Onur; Yüce, Hande; Erbaycu, Ahmet Emin; Ayranci, Aysu
    Objective: On 6 February 2023, 2 earthquakes with magnitudes of 7.8 and 7.6 Mw occurred in Kahramanmaraş. Earthquakes have caused catastrophic damage in an area of approximately 350,000 km². We aimed to establish the effect of earthquakes on asthma control. Material and Methods: The data of 116 asthma patients were assessed between May 1 and December 1, 2023. The use of inhaled corticosteroids (ICS), short-acting beta-agonists (SABA), and numbers of asthma exacerbations were compared in pre-and post-earthquake periods. In addition, patients were divided into 2 groups according to asthma control status. Both groups were compared for demographic data, medication, exacerbations, anxiety, and quality of life. Results: In the post-earthquake period, ICS use decreased significantly (p<0.001), while SABAs use and exacerbation rate increased significantly (p<0.001, p<0.001). Approximately 2/3 (66.4%) of patients were un-controlled. Exacerbations were significantly higher in the uncontrolled group (p=0.011). ICS use was also lower in the uncontrolled group (un-controlled: 28.6% vs 53.8% controlled, p=0.008). However, no significant difference was found between the groups for SABAs use. There was no difference between the two groups in terms of housing status (p=0.497), quality of life (p>0.05 for all quality-of-life scales), and anxiety level (p=0.686). Conclusion: We found that the earthquake significantly impaired asthma control. The main reason for the lack of asthma control in the post-earthquake period seems to be the difficulty in accessing ICS. Therefore, disaster management plans should be developed to provide timely medical supplie and optimal health services in areas vulnerable to disasters. © 2024 by Türkiye Klinikleri.