Ghayyad, KassemKilic, Ali Ihsan2024-03-092024-03-0920232168-8184https://doi.org/10.7759/cureus.49182https://hdl.handle.net/20.500.14034/1518Angioleiomyomas are benign tumors that originate from smooth muscle cells and most commonly affect organs such as the uterus or gastrointestinal tract. This article presents a case of a rarely reported angioleiomyoma located in the retropatellar juxta-articular region of the knee. The patient is a 42-year-old female who experienced chronic anterior knee pain that led to two unsuccessful arthroscopic surgeries. Magnetic resonance imaging (MRI) revealed a well-defined lesion in the retropatellar area, prompting the decision to proceed with open surgery. The histopathological examination confirmed the diagnosis of angioleiomyoma. This case highlights the challenges in diagnosing angioleiomyomas in the knee and emphasizes the importance of comprehensive MRI evaluation for accurate diagnosis and appropriate surgical intervention. Prompt identification and excision of the soft tissue lesion can lead to the complete resolution of symptoms and effective management of this rare condition.eninfo:eu-repo/semantics/openAccessRetropatellar; Surgical Case Reports; Arthroscopy; Angioleiomyoma; Juxta-ArticularArticle10.7759/cureus.491821511N/AWOS:00111082160000538130529N/A