Arslan, SeldaBahçeli, Pınar Zorbaİlik, YeterArtac, Mehmet2022-02-152022-02-1520201462-38891532-2122https://doi.org/10.1016/j.ejon.2020.101827https://hdl.handle.net/20.500.14034/101Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) may frequently occur in patients receiving oxaliplatin-based treatment. The aim of the present parallel-group, randomized, controlled pilot trial was to investigate the effect of henna on CIPN in women receiving oxaliplatin-based treatment. Method: Sixty female patients receiving oxaliplatin-based treatment were randomly divided into two groups, i.e., one intervention group (n = 30) where henna was applied topically and one control group (n = 30) that received routine treatment and care. Women in the intervention group were provided a pack of henna prepared by the investigators following each treatment course (2nd, 3rd, and 4th courses) and were instructed to apply the henna on their palms, fingers, and soles. The chemotherapy-induced peripheral neuropathy assessment tool (CIPNAT) was completed by women subsequent to the 2nd (baseline), 3rd, and 4th courses of treatment. Results: The intragroup assessment performed for the intervention group revealed that the total CIPNAT score significantly declined in the intervention group (p < 0.05). The score changes by time in the intervention and control groups were in favour of the intervention group, and the effect size for group x time interaction was eta(2) = 0.169. Similarly, regarding the symptoms intervention section of the tool, a positive change by time in the intervention group was observed, and the effect size concerning this change was large, i.e., eta(2) = 0.284. Conclusions: The present study results showed that henna application on hands and feet has a beneficial effect on peripheral neuropathy. Applying henna is a promising approach in CIPN management.eninfo:eu-repo/semantics/closedAccessChemotherapy-induced peripheral neuropathyHennaNursingNon-pharmacological interventionComplementary therapiesQuality-Of-LifeBreast-CancerTopical HennaAcupunctureManagementDiagnosisMassageArticle10.1016/j.ejon.2020.10182748Q1WOS:0005800284000252-s2.0-8509069636332932009Q1