Zeren, MelihDemir, RenginSinan, Ümit YaşarMustafaoğlu, RüstemYıldız, AbdurrahimKüçükoğlu, Mehmet Serdar2023-03-222023-03-2220220954-61111532-3064https://doi.org/10.1016/j.rmed.2022.106759https://hdl.handle.net/20.500.14034/767Background: In pulmonary arterial hypertension (PAH), pathophysiological consequences of the disease and the drugs used to treat PAH may adversely affect musculoskeletal system. Aim of the study was to evaluate musculoskeletal pain prevalence and its impact on quality of life (QoL) and exercise capacity in PAH patients. Methods: 61 PAH patients were evaluated with Nordic Musculoskeletal Questionnaire (NMQ) for musculoskeletal pain presence, EmPHasis-10 and Minnesota Living with Heart Failure Questionnaire (MLHFQ) for QoL, 6-min walk test (6MWT) for functional exercise capacity and International Physical Activity Questionnaire-Short Form (IPAQ-SF) for physical activity participation. Results: 77% of PAH patients reported musculoskeletal pain. Pain prevalence was highest at low back (38%), followed by knees (36%), shoulders (36%) and neck (33%). Hemodynamic indicators of PAH severity were associated with pain presence in various parts of the body. Patients receiving any PAH-specific drug were more likely to experience pain compared to the patients whose drug therapy has not yet been initiated (RR = 1.6-2.0). Pain presence in neck, shoulder, low back and knees significantly correlated to worse QoL scores in both EmPHasis-10 and MLHFQ (p < 0.05). Pain presence in knees had the strongest influence on QoL, and it was the only significant correlate of 6MWT (r =-0.424) and IPAQ-SF (r =-0.264) (p < 0.05). Conclusions: Musculoskeletal pain is a common complaint in PAH patients, which significantly impairs QoL and physical functioning. Treatment strategies should include a more comprehensive assessment for musculoskeletal pain complaints of these patients and address pain presence accordingly, which may help providing a better management for PAH.eninfo:eu-repo/semantics/closedAccessPulmonary arterial hypertensionMusculoskeletal systemPainQuality of lifeFunctional exercise capacityDrug therapyPhysical-Activity QuestionnaireLow-Back-PainMuscle StrengthKnee PainDiseaseOsteoarthritisReliabilityArticle10.1016/j.rmed.2022.106759193Q2WOS:0007596492000042-s2.0-8512419147435134632Q1