İnal, AbdullahSaydam, Serdar2022-02-152022-02-1520212458-89382564-7288https://doi.org/10.30621/jbachs.977476https://hdl.handle.net/20.500.14034/292Purpose: Low incidence of surgery-induced peritoneal adhesions in posttransplant patients is a wellknown subject. The aim of this study was to investigate the role sirolimus to prevent intra-abdominal adhesions and compare the systemic and intraperitoneal efficacy of the intervention. Methods: A total of 21 male rats randomly constituted three groups as intraperitoneal 0.015mg/kg sirolimus administered group, 0.1 mg/kg oral sirolimus administered group, and control group. A surgical peritoneal adhesion model was performed. All rats were euthanized on postoperative 7. day for macroscopic adhesion evaluation and histopathologic examination. Results: Intraperitoneal sirolimus administration significantly reduced adhesion formation. On the other hand, one-dose systemic administration did not show significant difference compared with control group. Conclusions: Intraperitoneal sirolimus administration at therapeutic doses significantly reduces postoperative intraabdominal adhesions in rat model.eninfo:eu-repo/semantics/openAccessSurgery-Induced Tissue AdhesionsSirolimusSurgical AdhesionsPostsurgical AdhesionsAbdominal AdhesionsPreventionAntibodiesInterleukin-6ReductionRapamycinTherapyModelArticle10.30621/jbachs.97747653195200N/AWOS:000713673500025505619