Refining the Neuroimaging Definition of the Dandy-Walker Phenotype

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dc.authorscopusid55255549900
dc.authorscopusid36163858300
dc.authorscopusid57217853617
dc.authorscopusid57195954738
dc.authorscopusid8554164700
dc.authorscopusid16308002500
dc.authorscopusid22956883800
dc.contributor.authorWhitehead M.T.
dc.contributor.authorBarkovich M.J.
dc.contributor.authorSidpra J.
dc.contributor.authorAlves C.A.
dc.contributor.authorMirsky D.M.
dc.contributor.authorÖztekin Ö.
dc.contributor.authorBhattacharya D.
dc.date.accessioned2023-03-22T19:47:53Z
dc.date.available2023-03-22T19:47:53Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractBACKGROUND AND PURPOSE: The traditionally described Dandy-Walker malformation comprises a range of cerebellar and posterior fossa abnormalities with variable clinical severity. We aimed to establish updated imaging criteria for Dandy-Walker malformation on the basis of cerebellar development. MATERIALS AND METHODS: In this multicenter study, retrospective MR imaging examinations from fetuses and children previously diagnosed with Dandy-Walker malformation or vermian hypoplasia were re-evaluated, using the choroid plexus/tela choroidea location and the fastigial recess shape to differentiate Dandy-Walker malformation from vermian hypoplasia. Multiple additional measures of the posterior fossa and cerebellum were also obtained and compared between Dandy-Walker malformation and other diagnoses. RESULTS: Four hundred forty-six examinations were analyzed (174 fetal and 272 postnatal). The most common diagnoses were Dandy-Walker malformation (78%), vermian hypoplasia (14%), vermian hypoplasia with Blake pouch cyst (9%), and Blake pouch cyst (4%). Most measures were significant differentiators of Dandy-Walker malformation from non-Dandy-Walker malformation both pre- and postnatally (P,.01); the tegmentovermian and fastigial recess angles were the most significant quantitative measures. Posterior fossa perimeter and vascular injury evidence were not significant differentiators pre- or postnatally (P..3). The superior posterior fossa angle, torcular location, and vermian height differentiated groups postnatally (P,.01), but not prenatally (P..07). CONCLUSIONS: As confirmed by objective measures, the modern Dandy-Walker malformation phenotype is best defined by inferior predominant vermian hypoplasia, an enlarged tegmentovermian angle, inferolateral displacement of the tela choroidea/choroid plexus, an obtuse fastigial recess, and an unpaired caudal lobule. Posterior fossa size and torcular location should be eliminated from the diagnostic criteria. This refined phenotype may help guide future study of the numerous etiologies and varied clinical outcomes. © 2022 American Society of Neuroradiology. All rights reserved.en_US
dc.identifier.doi10.3174/ajnr.A7659
dc.identifier.endpage1493en_US
dc.identifier.issn01956108
dc.identifier.issue10en_US
dc.identifier.pmid36137655en_US
dc.identifier.scopus2-s2.0-85143222544en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1488en_US
dc.identifier.urihttps://doi.org/10.3174/ajnr.A7659
dc.identifier.urihttps://hdl.handle.net/20.500.14034/897
dc.identifier.volume43en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmerican Society of Neuroradiologyen_US
dc.relation.journalAmerican Journal of Neuroradiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArticleen_US
dc.subjectblood vessel injuryen_US
dc.subjectbrain cysten_US
dc.subjectbrain developmenten_US
dc.subjectcerebellumen_US
dc.subjectcerebellum hypoplasiaen_US
dc.subjectcerebellum vermisen_US
dc.subjectchilden_US
dc.subjectchoroid plexusen_US
dc.subjectcohort analysisen_US
dc.subjectcontrolled studyen_US
dc.subjectDandy Walker syndromeen_US
dc.subjectdiagnostic accuracyen_US
dc.subjectfastigial nucleusen_US
dc.subjectfemaleen_US
dc.subjectfetusen_US
dc.subjectheighten_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectneuroimagingen_US
dc.subjectnuclear magnetic resonance imagingen_US
dc.subjectperinatal perioden_US
dc.subjectphenotypeen_US
dc.subjectposterior fossaen_US
dc.subjectquantitative analysisen_US
dc.subjectretrospective studyen_US
dc.subjectcerebellumen_US
dc.subjectclinical trialen_US
dc.subjectcysten_US
dc.subjectdiagnostic imagingen_US
dc.subjectmulticenter studyen_US
dc.subjectneuroimagingen_US
dc.subjectproceduresen_US
dc.subjectCerebellumen_US
dc.subjectCranial Fossa, Posterioren_US
dc.subjectCystsen_US
dc.subjectDandy-Walker Syndromeen_US
dc.subjectHumansen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectNeuroimagingen_US
dc.subjectRetrospective Studiesen_US
dc.titleRefining the Neuroimaging Definition of the Dandy-Walker Phenotypeen_US
dc.typeArticleen_US

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