Evaluation of Potential Candidate Genes in the Differentiation of Neoplastic and Non-neoplastic Conditions of Endometrium

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dc.contributor.authorDevrim, Tuba
dc.contributor.authorDevrim, Alparslan Kadir
dc.contributor.authorSenol, Ali
dc.contributor.authorSudagidan, Mert
dc.contributor.authorAtalay, Emine Sumeyye
dc.date.accessioned2025-03-20T09:44:55Z
dc.date.available2025-03-20T09:44:55Z
dc.date.issued2025
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractBackground: Endometrial cancer is one of the most common malignancies and alternative successful biomarkers are needed in the diagnostic process. Objectives: This study aimed to investigate candidate genes' diagnostic potential in endometrial neoplasia. Material and Methods: The expression levels of USP28, JAG2, AURKA, PGK1, HRPT1, EZH2, YAP, and P53 genes were evaluated by qPCR and/or immunohistochemistry analyses on endometrioid-type adenocarcinomas including all three grades, as well as from non-atypical hyperplasia, and atypical hyperplasia. Results: We determined significant (p < 0.05) increases in USP28, PGK1, EZH2, JAG2, AURKA, and YAP mRNA expressions in endometrial cancer tissues. Significant differences in the expressions of USP28 and P53 genes were determined between tumor grade groups (p = 0.002, and p = 0.005, respectively). Immunohistochemically, significant differences were found between the study groups (p < 0.001) and tumor grades (p = 0.013) by the evaluation of USP28. Statistically significant differences were found between all study groups (p < 0.001) and tumor grades (p = 0.008) in terms of PGK1 immunohistochemical expressions. A positive correlation (p = 0.002, r = 0.356) was found between p53 and PGK1. Conclusions: Considering our qPCR and immunohistochemistry results together, it was concluded that USP28, PGK1, EZH2, JAG2, AURKA, HPRT1and YAP expressions could offer beneficial expression values in precancerous lesions and endometrial cancer. © The Author(s) 2025.
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK
dc.description.sponsorshipKirikkale University Coordination Office of Scientific Research Projects, (2020/065)
dc.identifier.doi10.1007/s44411-024-00004-5
dc.identifier.issn0006-9248
dc.identifier.scopus2-s2.0-85217745101
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s44411-024-00004-5
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2062
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer International Publishing
dc.relation.ispartofBratislava Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250319
dc.subjectBiomarker
dc.subjectDifferentially expressed genes
dc.subjectEndometrial carcinoma
dc.subjectImmunohistochemistry
dc.subjectqPCR
dc.titleEvaluation of Potential Candidate Genes in the Differentiation of Neoplastic and Non-neoplastic Conditions of Endometrium
dc.typeArticle

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