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    Diagnostic value of pleural fluid lactate dehydrogenase/adenosine deaminase ratio in differentiating parapneumonic effusion from tuberculous pleurisy
    (Wolters Kluwer Medknow Publications, 2021) Anar, Ceyda; Yavuz, Melike Yuksel; Alici, Ibrahim Onur; Guldaval, Filiz; Buyuksirin, Melih
    Objective The purpose of this study was to determine the diagnostic value of pleural fluid lactate dehydrogenase (LDH)/pleural fluid adenosine deaminase (ADA) ratio in differentiating pleural effusions owing to tuberculous pleurisy (TBP) and parapneumonic effusion (PPE). Patients and methods The data of 272 patients (140 patients with TBP and 132 patients with PPE) between January 2012 and October 2018 were analyzed retrospectively. Demographic data of all patients; concurrent serum glucose, albumin, protein, and LDH values; and pleural fluid pH, glucose, albumin, protein, and ADA results have been reviewed. Results Pleural fluid ADA values were statistically significantly higher in the TBP group than PPE (P<0.001). The median values of pleural fluid LDH/ADA ratio between TBP and PPE groups were 16.10 (12.53) and 32.90 (34.45), respectively, which was found to be significantly lower in TBP group (P<0.001). Pleural fluid LDH/ADA ratio's sensitivity, specificity, positive predictive value, and negative predictive value were 90, 59.85, 70.4, and 84.9%, respectively, in the diagnosis of TBP for values less than 28 (P<0.001). Conclusion The ratio of pleural fluid LDH/ADA determined from routine biochemical analysis predicts TBP at value of 28. Measurement of this parameter may help clinicians distinguish between TBP and PPE.
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    Levels of oxidative stress, selenium and zinc, and health-related quality of life in healthy males before and after COVID-19 vaccination
    (Dustri-Verlag Dr Karl Feistle, 2024) Ozdemir, Kadirhan; Saruhan, Ercan; Benli, Tuba Kaya; Kaya, Gozde; Cil, Zafer; Yavuz, Melike Yuksel; Meral, Orhan
    Objective: The aim of this study was to determine the changes in oxidative stress, selenium (Se) and zinc (Zn), and health-related quality of life (HRQoL) following COVID-19 vaccination. Materials and methods: 20 healthy male subjects received 2 doses of inactivated COVID-19 vaccines between January and August 2021. Peripheral blood samples were taken immediately before the 1 st dose and 3 days after the 2 nd dose of the vaccine. The oxidant status (malondialdehyde (MDA) and total oxidant status (TOS)), antioxidant status (superoxide dismutase (SOD) and total antioxidant status (TAS)), Se and Zn, and HRQoL levels of the subjects were evaluated. In addition, oxidative stress index (OSI) was calculated. Results: The mean age and body mass index of the subjects were 45.85 +/- 6.38 years and 28.53 +/- 4.50 kg/m(2), respectively. Following COVID-19 vaccinations, TAS levels decreased (p = 0.004); however, SOD levels increased (p = 0.012) significantly. In addition, there were no significant changes in TOS and MDA levels (p > 0.05). Moreover, OSI showed no significant differences (p > 0.05). After the vaccination process, Se and Zn increased; however, the differences were insignificant (p > 0.05). In addition, the HRQoL of the subjects did not change (p > 0.05). Conclusion: Although the antioxidant status decreased after 2 doses of COVID-19 vaccination, the oxidant status and the oxidative stress levels of the subjects remained stable. Thus, 2 doses of inactivated COVID-19 vaccination may have no effects on oxidative stress levels in healthy males. In addition, there were no changes in the serum concentrations of Se and Zn. Moreover, there was no difference in the HRQoL of the subjects. Therefore, COVID-19 vaccination process may not affect serum Se and Zn levels and HRQoL in healthy males.