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  • Küçük Resim
    Öğe
    Comparison of trace element (selenium, iron), electrolyte (calcium, sodium), and physical activity levels in COVID-19 patients before and after the treatment
    (Elsevier Gmbh, 2022) Özdemir, Kadirhan; Saruhan, Ercan; Benli, Tuba Kaya; Kaya, Gözde; Meral, Orhan; Yavuz, Melike Yüksel; Şen, Teoman
    Objective: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), a worldwide health problem, is the cause of 2019 coronavirus disease. This study aimed to compare the trace element (selenium and iron), electrolyte (calcium and sodium), and physical activity levels of COVID-19 patients before and after COVID-19 treatment. Method: This prospective study was conducted in patients diagnosed with COVID-19 (n = 15). Trace element (selenium and iron), electrolyte (calcium and sodium), and physical activity levels of the patients were compared before and after the treatment. Result: Most of patients had selenium deficiency (86.7 %), iron deficiency (73.3 %), calcium deficiency (66.7 %) and sodium deficiency (46.7 %) before COVID-19 treatment. The most important improvements were seen in iron deficiency (from 73.3 % to 26.7 %) and sodium deficiency (from 46.7 % to 13.3 %) after the treatment. Selenium, iron, calcium, and sodium levels of the patients were significantly higher after the treatment (p < 0.05). The patients had low physical activity before and after COVID-19 treatment. In addition, no statistically significant difference was found in the comparison of physical activity levels (p > 0.05). Conclusion: This study indicated that selenium, iron, calcium, and sodium levels and deficiencies might improve after treating patients with COVID-19. However, the results of this study showed that the physical activity levels of COVID-19 patients might remain stable and low throughout the treatment process.
  • Küçük Resim
    Öğe
    COVID-19 sonrası devam eden semptomlar, interstisyel akciğer hastalığı oluşumu ve takip süreci
    (2021) Yavuz, Melike Yüksel; Anar, Ceyda
    Aralık 2019’da Çin’in Wuhan eyaletinden severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)’ye bağlı ciddi akut solunum hastalıkları bildirildi. Koronavirüs hastalığı- 2019 (COVID-19) ilişkili semptomlar hafif üst solunum yolu infeksiyonundan akut solunum sıkıntısı sendromu (ARDS)’na kadar çeşitli klinik farklılık gösterir. Taburculuk sonrası bazı hastalarda semptomların ve radyolojik bulguların devam ettiği görülmüştür. Hipertansiyon ve diyabet gibi komorbiditeler, erkek cinsiyet ve ileri yaş gibi risk faktörleri ciddi COVID-19 ve idiopatik pulmoner fibrosis (İPF) için ortak risk faktörleridir. Bununla birlikte, SARS-CoV-2 infeksiyonuna yakalanan İPF hastalarında, antifibrotik tedavinin rolü ve bunların devamı veya kesilmesi için bilimsel mantık tam olarak tanımlanmamıştır. COVID-19 pandemisinden edinilen veriler ile şiddetli akut solunum sendromu (SARS) ve Ortadoğu solunum sendromu (MERS) gibi önceki koronavirüs infeksiyonlarından elde edilen veriler, SARS-CoV-2 infeksiyonunu takiben önemli fibrotik değişiklikler olabileceğini düşündürmektedir. Bu makalede, COVID-19 pnömonisi sonrası devam eden semptomların sıklığı ve ortaya çıkabilecek interstisyel akciğer hastalığı sıklığından söz edildi. Ayrıca başta pulmoner fibrosis olmak üzere akciğerde meydana gelen interstisyel değişikliklerin önlenmesi ve solunum fonksiyonlarında azalma literatür ışığında tartışılmıştır.
  • Küçük Resim
    Öğe
    Prognostic effects of neutrophil-lymphocyte rates in serum and pleural fluids in malignant pleural fluids
    (2021) Ayrancı, Aysu; Yavuz, Melike Yüksel; Anar, Ceyda; Karadeniz, Gülistan; Polat, Gülru; Büyükşirin, Melih; Güldaval, Filiz
    Objective: Various studies have reported that the neutrophil-to-lymphocyte ratio in the serum (sNLR) may serve as a cost-effective and useful prognostic factor in patients with various cancer types. We investigated the clinical impact of NLR as a prognostic factor in malign pleural effusion (MPE) and sNLR on prognosis in MPE. Method: We retrospectively reviewed all of the patients who were diagnosed MPE. The relationship between sNLR and neutrophil-to-lymphocyte ratio in the malign pleural effusion (mNLR) value, age, Eastern Cooperative Oncology Group (ECOG), histopathologic type, serum albumin and lactate dehydrogenase (LDH) with survival were investigated. Results: A total of 222 patients with a mean age of 65.7±11.5 were included in the study. Patients with a mNLR value ?0.42 and a serum NLR value ?4.75 had a shorter survival (p: 0.000). Multivariate analysis, which showed that survival was significantly related mNLR value > 0.42 and/or sNLR value > 4.75 (Odds Ratio (OR): 2.66, %95 CI, 1,65-4,3 p: 0.001), serum LDH > 210 (OR = 1.8, %95 CI, 1,33-2,46 p: 0.001) and age > 65 (OR = 1.9, %95 CI, 1,41-2,55 p = 0.001). Conclusion: sNLR and mNLR may act as a simple, useful, and cost-effective prognostic factor in patients with MPE. Furthermore, these results may serve as the cornerstone of further research into the mNLR in the future. Although further studies are required to generalize our results, this information will benefit clinicians and patients in determining the most appropriate therapy for patients with MPE.