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Öğe Coenzyme q10 effectively prevents age-related hearing loss in c57bl/6 mice(Geriatrics Society, 2021) Müderris, Togay; Sevil, Ergun; Yar Sağlam, A.S.; Babademez, M.A.Introduction: Presbycusis is characterized by gradual, progressive sensorineural hearing loss. The aim of this study is to evaluate the effects of coenzyme Q10 in the prevention and treatment of age-related hearing loss. Materials and Method: Thirty-two C57BL/6 mice were assigned into four groups as early treatment, late treatment, control and sham control. Treatment was started at three months of age in the early treatment group and at six months in the late treatment group. The auditory brainstem test was performed once every three months. At the end of the study period, the cochleae of the animals were harvested, and Bcl-2, Bcl-xL, iNOS, COX-2, NF-?B, Bax, and Bak levels were analyzed with real-time polymerase chain reaction. Results: The hearing thresholds of the mice in the early treatment group were better than those of the other groups (p < 0.001). Hearing levels were also better in the late treatment group than control groups, but the difference was not significant (p > 0.05). The threshold shift in the early treatment group was significantly lower than the control groups (p < 0.001). The mRNA expression levels of proapoptotic genes Bax and Bak were lower (p < 0.05), antiapoptotic genes Bcl-2 and Bcl-xL were higher (p < 0.05), and the NF-?B, COX-2, and iNOS genes, which play a role in inflammation, were lower (p < 0.05) in the early treatment group. Conclusion: These results suggest that coenzyme Q10 effectively attenuates the presentation of age-related hearing loss, especially when started before the onset of hearing loss. © 2021, Geriatrics Society. All rights reserved.Öğe Efficiency of resveratrol in the prevention and treatment of age-related hearing loss(Spandidos Publ Ltd, 2022) Müderris, Togay; Sağlam, Atiye; Ünsal, Döndü; Mulazimoğlu, Selçuk; Sevil, Ergun; Kayhan, HandanAge-related hearing loss (ARHL) is a major public health concern, which is characterized by gradual, progressive sensorineural hearing loss and deterioration of sound localization, with no effective treatment available to date. The aim of the present study was to evaluate the efficacy of resveratrol to prevent and treat ARHL. For this purpose, 32 male C57BL/6 mice were assigned to four groups: Early treatment, late treatment, control and sham control. The experiment lasted for 15 months. Treatment was started at three months of age in the early treatment group and at sixth months in the late treatment group. The auditory brainstem response test was performed once every three months. At the end of the study period, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, NF-kappa B, Bcl-2, Bcl-xL, Bax, Bcl-2 homologous antagonist/killer (Bak), caspase-3 and caspase-9 levels in the cochlear tissues of the animals were analyzed by reverse transcription-quantitative PCR. Hearing thresholds of the mice in the early treatment group were better than those in the other groups (P<0.001) at the end of the study. However, hearing levels in the late treatment group were not significantly different from those in the control groups (P>0.05), although mean thresholds were lower. The threshold shift in the early treatment group was significantly lower at all frequencies when compared with those in the control groups (P<0.001). The mRNA expression levels of pro-apoptotic genes Bax and Bak were lower (P<0.05), anti-apoptotic genes Bcl-2 and Bcl-xL were higher (P<0.05), NF-kappa B, COX-2 and iNOS as genes that have a role in inflammation and caspase-3 and caspase-9 as genes with a vital role in apoptosis were lower (P<0.05) in the early treatment group when compared with the late treatment and control groups. These results suggested that resveratrol is effective in the prevention of ARHL, particularly when started prior to the beginning of hearing loss.Öğe Transoral robotic supraglottic laryngectomy: Long-term functional and oncologic outcomes(W B Saunders Co-Elsevier Inc, 2024) Muderris, Togay; Sevil, Ergun; Gul, FatihObjectives: Minimally invasive transoral organ preservation surgeries are being increasingly used for supraglottic tumors. This study investigates the long-term functional and oncologic outcomes of transoral robotic supraglottic laryngectomy (TORS-SGL).Materials and methods: Twenty-three patients with supraglottic laryngeal cancer who underwent TORS-SGL be-tween 2012 and 2015 at a tertiary referral hospital were retrospectively analyzed with at least 5 years of follow-up. The head and neck tumor council and the multidisciplinary oncological board decided whether the patients were suitable for robotic surgery, and the necessity of adjuvant radiotherapy or chemotherapy. Inclusion criteria was histopathological diagnosis of squamous cell carcinoma of the larynx.Results: Twenty-one patients with T1-T3 supraglottic squamous cell carcinoma were included in this study. Mean follow-up was 48.8 months. Local control was 94.4 % at 2 years and 85.9 % at 5 years. Disease-free survival and overall survival were 85.7 % and 81 % at 2 years and 69.3 % and 57.1 % at 5 years, respectively. There was no permanent tracheostomy or prolonged swallowing dysfunction among patients. Age, perineural and lympho-vascular invasion were found to be risk factors affecting overall survival.Conclusion: TORS-SGL is a feasible, safe and reliable approach with excellent functional results for T1, T2, and selected T3 supraglottic tumors, providing acceptable long-term oncologic results when compared to alternative treatment modalities.Öğe Tükürük bezi tümörü tanısında ultrasonografi (USG), mangnetik rezonans görüntüleme (MRG), bilgisayarlı tomografi (BT), ince iğne aspirasyon biyopsisi’nin (İİAB) karşılaştırılması(2020) Doblan, Ahmet; Sevil, Ergun; Müderris, Togay; Kırış, MuzafferGiriş: Tükürük bezleri tümörlerinde benign ve malign neoplazm arasındaki preoperatif farklılıkların belirlenmesi cerrahi operasyonun gerekliliği, aciliyeti ve kapsamını belirlemede önemlidir. Çalışmanın amacı, tükürük bezi kitlesi nedeniyle opere olmuş hastalarda, tükürük bezi tümörlerinin tanımlayıcı özelliklerinin ve tanı yöntemlerinin tanısal değerlerinin belirlenmesidir.Yöntemler: Çalışma, 2008-2016 yılları arasında, tükürük bezinde malign veya benign kitle nedeni ile opere edilen hastaların, tıbbi kayıtlarının retrospektif incelenmesi ile yapılan tanımlayıcı tipte bir araştırmadır. Hastalara preoperatif dönemde yapılan Ultrasonografi (USG), Magnetik Rezonans Görüntüleme (MRG), Bilgisayarlı Tomografi (BT), İnce İğne Aspirasyon Biyopsisi’nin (İİAB) sonuçları ve postoperatif dönemde histopatolojik tetkik sonuçları değerlendirildi. Kullanılan tanı yöntemlerinin sensitivite, spesifite, pozitif prediktif değer (PPD), negatif prediktif değer (NPD), eğri altında kalan alan (AUC±SE) değerlerinin hesaplanması için ROC analizi yapıldı.Bulgular: Çalışma grubu 114 kişiden oluşmakta olup yaş ortalamaları 46.90±14.32 yıl idi. Çalışma grubunun %54.4’ü erkek, %71.9’u 40 yaşın üstündeydi. Tükürük bezi tümörlerinin %71.9’u parotiste idi. Hastaların tanı amaçlı yapılan histopatoloji incelemesinde % 11.4’ünün malign tümöre sahip olduğu bulundu. Hastalarda en sık rastlanan benign tümör çeşidi pleomorfik adenom, en sık rastlanan malign tümör çeşidi mukoepidermoid kanser olarak saptandı. Sensitivite, NPD, AUC±SE değerlerinin en yüksek olduğu yöntem MRG, spesifite ve PPD değerlerinin en yüksek olduğu yöntem İİAB idi.Sonuç ve Öneriler: Sonuç olarak, hastalarda tükürük bezi tümörlerinin en sık parotis bezinde (%11.4’ü malign) görüldüğü, en sık benign tükürük bezi tümörünün pleomorfik adenom, en sık malign tükürük bezi tümörünün mukoepidermoid kanser olduğu bulundu. Sensitivite, NPD, AUC±SE değeri en yüksek olan yöntem MRG ve spesifite ve PPD değeri en yüksek olan yöntem İİAB idi. USG, BT, MRG, İİAB’nin tükürük bezi tümörlerindeki tanısal değerlerini inceleyen, daha geniş örneklemlerde yapılacak klinik araştırmaların faydalı olacağı düşünüldü.
