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Öğe Analysis of the correlation between thyroid hormones and thyroid volume by gender: A volumetric computed tomography study(2022) Öner, Zülal; Öner, Serkan; Secgin, Yusuf; Toy, ŞeymaThe aim of this study was to evaluate the correlation between triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) hormones and thyroid gland volume with volumetric analysis performed by using computed tomography (CT) images. In this retrospective study, IV contrasted thoracic CT images taken for different indications between 2019 January and 2020 January were scanned from the archive system of the hospital. 67 (31F, 36M) individuals chosen randomly among patients whose CT results were reported as normal and who had taken thyroid hormone tests within the past week were included in the study. Images in Digital Imaging and Communications in Medicine format were transferred to the personal work station program (Horos Medical Image Viewer). By using the Region of Interest (ROI) console in the current program, a three dimensional model was obtained by drawing the border of the thyroid gland in sections varying between 15 and 25. Volume values of this three-dimensional model and TSH, T3, T4 values of the individuals were compared. While no correlation was found between thyroid gland volume and T3 and T4 hormones, a negative significant correlation was found with TSH. In terms of gender, thyroid gland volume, T3, T4 values were found to be statistically significantly higher in women when compared with men (p?0.05). TSH value was found to be higher in women when compared with men (p=0.005). No statistically significant difference was found in T4 value (p=0.057). Radio-anatomical volumetric data of the thyroid gland presented in this study and its correlation with thyroid functions will be beneficial to clinicians working in the field in both internal and surgical medicine branches and will also guide future studies.Öğe Analysis of the effects of total pneumatized turbinate volume on septum deviation, maxillary sinus volume, and maxillopalatal parameters: A multidetector computerized tomography study(Wolters Kluwer Medknow Publications, 2023) Senol, Deniz; Oner, Serkan; Secgin, Yusuf; Oner, Zulal; Toy, SeymaIntroduction: The aim of this study was to examine the effects of pneumatized turbinate volume (PTV) on nasal septum deviation (NSD), maxillary sinus volume (MSV), and maxillopalatal parameters with multidetector computed tomography (MDCT). Material and Methods: MDCT images of a total of 73 patients (35 females and 38 males) between the ages of 25 and 58 years were used in the study. PTV, MSV, and NSD angle and direction and interalveolar distance (IAD), maxillary spin distance (MSD), and maxillopalatal angle (MPA) measurements were made on images brought to the orthogonal plane in 3 plans. Results: Turbinate pneumatization (superior, middle, or inferior) was found in a total of 55 (75.3%) patients (28 females and 27 males). The number of patients with turbinate pneumatization on the right side was 14 (19.2%), while the number of patients with turbinate pneumatization on the left side was 15 (20.5%) and the number of bilateral pneumatization was 26 (35.6%). While no significant association was found between the presence of turbinate pneumatization and septal deviation angle, MSV, MPA, IAD, and MSD measurements, a significant difference was found between the groups in terms of PTV (P < 0.05). No significant association was found between NSD direction and all parameters. Discussion and Conclusion: In this study, we conducted with MDCT images, in addition to the highest incidence in turbinate pneumatization with 75.3%; it was found that PTV did not have an effect on NSD amount, MSV, and maxillopalatal parameters. Men were found to have higher NSD angle, higher maxillary sinus aeration, and larger IAD when compared with women.Öğe Can Typical Cervical Vertebrae Be Distinguished from One Another by Using Machine Learning Algorithms? Radioanatomic New Markers(Duzce Univ, Fac Medicine, 2023) Senol, Deniz; Secgin, Yusuf; Toy, Seyma; Oner, Serkan; Oner, ZulalObjective: The aim of this study is to distinguish the typical cervical vertebrae that cannot be separated from one another with the naked eye by using machine algorithms (ML) with measurements made on computerized tomography (CT) images and to show the differences of these vertebrae.Methods: This study was conducted by examining the 536 typical cervical vertebrae CT images of 134 (between the ages of 20 and 55) individuals. Measurements of cervical vertebrae were made on coronal, axial and sagittal section. 6 different combinations (Group 1: C3 - C4, Group 2: C3 - C5, Group 3: C3 - C6, Group 4: C4 - C5, Group 5: C4 - C6, Group 6: C5 - C6) were formed with parameters of each vertebrae and they were analyzed in ML algorithms. Accuracy (Acc), Matthews correlation coefficient (Mcc), Specificity (Spe), Sensitivity (Sen) values were obtained as a result of the analysis.Results: As a result of this study, the highest success was obtained with Linear Discriminant Analysis (LDA) and Logistic Regression (LR) algorithms. The highest Acc rate was found as 0.94 with LDA and LR algorithm in Groups 3 and Group 4, the highest Spe value was found as 0.95 with LDA and LR algorithm in Group 5, the highest Mcc value was found as 0.90 with LDA and LR algorithm in Group 5 and the highest Sen value was found as 0.94 with LDA and LR algorithm in Groups 3 and 5. Conclusions: As a conclusion, it was found that typical cervical vertebrae can be distinguished from each other with high accuracy by using ML algorithms.Öğe Determination of Sex Differences Using Machine Learning Algorithms and Artificial Neural Networks with Parameters Obtained from Basilar Artery(Universidad de la Frontera, 2024) Secgin, Yusuf; Erkartal, Halil Saban; Tatlı, Melike; Toy, Seyma; Oner, Zulal; Oner, SerkanThe determination of sex differences in anatomical structures is critical in establishing gold standard morphometric data in basic medical sciences, and in surgical and internal sciences in selecting the right area during invasive intervention and applying the correct intervention methodology appropriate to the area. The aim of this study is to determine the sex difference using Machine learning (ML) algorithms and Artificial neural networks (ANN) with parameters obtained from basilar artery. The study was performed on computed tomography angiography images of 63 women and 94 men. The following parameters were measured on the images: initial width of the right vertebral artery, initial width of the left vertebral artery, termination width of the right vertebral artery, termination width of the left vertebral artery, basilar artery width, and basilar artery length. The measurements were used in ML algorithms and ANN input to determine sex differences. As a result of the study, a sex difference rate of 0.84 was determined with the ML algorithms Random Forest (RF), Quadratic Discriminant Analysis (QDA), Extra Tree Classifier (ETC) and 0.84 with the Multilayer Perceptron Classifier (MLCP) algorithm of ANN. As a result of the study, sex difference was found with an accuracy rate of 0.84 using ML algorithms and ANN with parameters obtained from basilar artery. In this context, we think that this study will shed light on basic and clinical medical sciences. © 2024, Universidad de la Frontera. All rights reserved.Öğe Gender Prediction Using Cone-Beam Computed Tomography Measurements from Foramen Incisivum: Application of Machine Learning Algorithms and Artificial Neural Networks(Wolters Kluwer Medknow Publications, 2024) Senol, Deniz; Secgin, Yusuf; Harmandaoglu, Oguzhan; Kaya, Seren; Duman, Suayip Burak; Oner, ZuelalIntroduction: This study aims to predict gender using parameters obtained from images of the foramen (for.) incisivum through cone-beam computed tomography (CBCT) and employing machine learning (ML) algorithms and artificial neural networks (ANN).Materials and Methods: This study was conducted on 162 individuals in total. Precise measurements were meticulously extracted, extending from the foramen incisivum to the arcus alveolaris maxillaris, through employment of CBCT. The ML and ANN models were meticulously devised, allocating 20% for rigorous testing and 80% for comprehensive training.Results: All parameters that are evaluated, except for the angle between foramen palatinum majus and foramen incisivum-spina nasalis posterior (GPFIFPNS-A), exhibited a significant gender difference. ANN and among the ML algorithms, logistic regression (LR), linear discriminant analysis (LDA), and random rorest (RF) demonstrated the highest accuracy (Acc) rate of 0.82. The Acc rates for other algorithms ranged from 0.76 to 0.79. In the models with the highest Acc rates, 14 out of 17 male individuals and 13 out of 16 female individuals in the test set were correctly predicted.Conclusion: LR, LDA, RF, and ANN yielded high gender prediction rates for the measured parameters, while decision tree, extra tree classifier, Gaussian Naive Bayes, quadratic discriminant analysis, and K-nearest neighbors algorithm methods provided lower predictions. We believe that the evaluation of measurements extending from foramen incisivum to arcus alveolaris maxillaris through CBCT scanning proves to be a valuable method in gender prediction.Öğe Gender prediction using geometric morphometry with parameters of the cranium obtained from computed tomography images(Cukurova Univ, Fac Medicine, 2024) Secgin, Yusuf; Oner, Zulal; Oner, Serkan; Toy, SeymaPurpose:The gender difference of the cranium skeleton is of great importance in forensic anthropology and forensic medicine sciences. This study is based on this hypothesis and the gender prediction rate was obtained by processing cranium images obtained from computed tomography (CT) using geometric morphometry.Materials and Methods:CT images of 200 individuals between the ages of 25 and 65 were used in our study. The images were opened at the personal workstation Horos Medical Image Viewer (Version 3.0, USA) program and processed with 3D Curved Multiplanar Reconstruction (MPR). The line passing through the nasion and inion points of the images obtained as a result of the process was determined, and all images were brought to the orthogonal plane. Later, the images were overlapped and saved in JPEG format with 100% magnification. JPEG images saved were converted into TPS format, and 21 homologous landmarks were placed. Generalized Procrustes Analysis (GPA) and Principal Component Analysis (PCA) were applied to thecoordinates of landmarks, and shape variations and dimensionality were corrected by gathering the images to the center of gravity. Next, Linear Discriminant Analysis (LDA) was applied to the coordinates, the dimensionality of which was corrected. Results:The study found that 74.465% of the coordinates of 21 homologous landmarks gathered to the center of gravity could be explained with the first three PCs. As a result of the LDA applied to these coordinates, a gender prediction rate of 86.5% was obtained.In addition, a slight difference was found between the GPA sum of squares and the tangent sum of squares (0.57). Conclusion:The images of the cranium obtained from CT showed a high dimorphism by geometric morphometry analysisÖğe Gender prediction with the parameters obtained from pelvis computed tomography images and machine learning algorithms(Wolters Kluwer Medknow Publications, 2022) Secgin, Yusuf; Oner, Zulal; Turan, Muhammed Kamil; Oner, SerkanIntroduction: In the skeletal system, the most dimorphic bones employed for postmortem gender prediction include the bones in the pelvic skeleton. Bone measurements are usually conducted with cadaver bones. Computed tomography (CT) is an increasingly popular method due to its ease of use, reconstruction opportunities, and lower impact of age bias and provides a modern data source. Even when parameters obtained with different or same bones are missing, machine learning (ML) algorithms allow the use of statistical methods to predict gender. This study was carried out in order to obtain high accuracy in estimating gender with the pelvis skeleton by integrating ML algorithms, which are used extensively in the field of engineering, in the field of health. Material and Methods: In the present study, pelvic CT images of 300 healthy individuals (150 females, 150 males) between the ages of 25 and 50 (the mean female age = 40, the mean male age = 37) were transformed into orthogonal images, and landmarks were placed on promontory, iliac crest, sacroiliac joint, anterior superior iliac spine, anterior inferior iliac spine, terminal line, obturator foramen, greater trochanter, lesser trochanter, femoral head, femoral neck, body of femur, ischial tuberosity, acetabulum, and pubic symphysis, and coordinates of these regions were obtained. Four groups were formed based on various angle and length combinations obtained from these coordinates. These four groups were analyzed with ML algorithms such as Logistic Regression, Linear Discriminant Analysis (LDA), Random Forest, Extra Trees Classifier, and ADA Boost Classifier. Results: In the analysis, it was determined that the highest accuracy was 0.96 (sensitivity 0.95, specificity 0.97, Matthew's Correlation Coefficient 0.93) with LDA. Discussion and Conclusion: The use of length and angle measurements obtained from the pelvis showed that the LDA model was effective in estimating gender.Öğe Sex and age estimation with machine learning algorithms with parameters obtained from cone beam computed tomography images of maxillary first molar and canine teeth(Int Assoc Law & Forensic Sciences, 2023) Senol, Deniz; Secgin, Yusuf; Duman, Burak Suayip; Toy, Seyma; Oner, ZulalBackgroundThe aim of this study is to obtain a highly accurate and objective sex and age estimation by using the parameters of maxillary molar and canine teeth obtained from cone beam computed tomography images in the input of machine learning algorithms. Cone beam computed tomography images of 240 people aged between 25 and 54 were randomly selected from the archive systems of the hospital and transferred to Horos Medikal. 3D curved multiplanar reconstruction was applied to these images and a 3D image was obtained. The resulting image was brought to the orthogonal plane and the measurements were made by superimposing them.ResultsThe results were grouped in four different age groups (25-30, 31-36, 37-49, 50-54) and recorded. As a result of our study, the highest accuracy rate was found as 0.81 in sex estimation with ADA Boost Classifier algorithm, while in age estimation, the highest accuracy rate was found as 0.84 between 25-30 and 31-36 age groups with random forest algorithm, as 0.74 between 25-30 and 37-49 age groups with random forest and ADA Boost Classifier algorithms and as 0.85 between 25-30 and 50-54 age groups with random forest algorithm.ConclusionsOur study differs from other studies in two aspects; the first is the selection of a sensitive method such as cone beam computed tomography, and the second is the selection of machine learning algorithms. As a result of our study, the highest accuracy rate was found as 0.81 in sex estimation and as 0.85 in age estimation with parameters of maxillary canine and molar teeth.Öğe A study on sex estimation by using machine learning algorithms with parameters obtained from computerized tomography images of the cranium(Nature Portfolio, 2022) Toy, Seyma; Secgin, Yusuf; Öner, Zülal; Turan, Muhammed Kamil; Oner, Serkan; Senol, DenizThe aim of this study is to test whether sex prediction can be made by using machine learning algorithms (ML) with parameters taken from computerized tomography (CT) images of cranium and mandible skeleton which are known to be dimorphic. CT images of the cranium skeletons of 150 men and 150 women were included in the study. 25 parameters determined were tested with different ML algorithms. Accuracy (Acc), Specificity (Spe), Sensitivity (Sen), F1 score (F1), Matthews correlation coefficient (Mcc) values were included as performance criteria and Minitab 17 package program was used in descriptive statistical analyses. p <= 0.05 value was considered as statistically significant. In ML algorithms, the highest prediction was found with 0.90 Acc, 0.80 Mcc, 0.90 Spe, 0.90 Sen, 0.90 F1 values as a result of LR algorithms. As a result of confusion matrix, it was found that 27 of 30 males and 27 of 30 females were predicted correctly. Acc ratios of other MLs were found to be between 0.81 and 0.88. It has been concluded that the LR algorithm to be applied to the parameters obtained from CT images of the cranium skeleton will predict sex with high accuracy.
