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Öğe ANADOLU TIBBINDA MÜZİKLE TEDAVİ(HTA Department of Turkish MoH, 2022) Ozbek, HanefiBu makalede, Anadolu’da müzikle tedavi konusunda eldeki bilgilerin bir derlemesi verilmeye çalışılmıştır. Öncelikle müziğin insanlık tarihinde ortaya çıkışından bahsedilmiş; daha sonra Anadolu’da müzik tarihi hakkında bilgiler özet olarak sunulmuştur. Anadolu’da yapılan müzik terapinin oluşumuna katkısı olduğu düşünülen ve farklı uygarlıklara ait müzikle tedavi konuları kısaca sunulmuştur. Buna göre İbranilerde müzikle tedavi, Eski Mısır’da müzikle tedavi, Eski Çin’de müzikle tedavi, Roma’da müzikle tedavi ve Eski Yunan’da müzikle tedavi konuları özetlenmiştir. Farabi’den günümüze kadar uzanan süreçte müzik terapi ile ilgili elde bulunan bilgiler sunulmuş; Farabi, İbni Sina, Razi gibi alimlerin bu konudaki görüşlerine kısaca yer verilmiştir. Anadolu Selçuklu dönemi ve Osmanlı döneminde Anadolu’da müzikle tedavi hakkında eldeki veriler sunulmuş; Musiki’ül Kebir, El Kanun Fi’t Tıb, Tadilü’l Emzice, Gevrekzade’nin musiki risalesi ve Haşim Bey Mecmuası’ndan bahsedilmiştir. Makamların hangi hastalıklara iyi geldiği, günün hangi vakitlerinde etkili olduğu gibi konular ayrıca işlenmiştir. Makamlar ve hangi hastalıklara iyi geldiklerinin bir listesi sunulmuştur. Müzikle tedavinin yapıldığı şifahaneler yine liste halinde verilmiştir. Anadolu’da 1800’lü yıllara kadar yapılmış olan müzikle tedavi ile ilgili eldeki bilgilerin bazen birbirini tutmadığı, hatta birbirine zıt bilgilerin bulunduğu belirtilmiştir. Sonuç olarak Anadolu’da Milattan Ön ceki yıllardan başlayıp 1800’lü yıllara kadar devam ettirilen bir müzikle tedavi geleneğinin bulunduğu bilinmektedir. Ancak bu tedavinin detayları maalesef net bir şekilde bilinmemektedir. Bu nedenle eldeki bilgiler tarihi ve folklorik bir bilgi olmaktan öteye gidememektedir. Bugün itibarıyla yapılması gereken şey günümüz tıp bilimi ve müzik bilgisinin kanıta dayalı bilimsel yöntemlerle araştırılması; elde edilen yeni bilgilere göre müzikle tedavinin yeniden şekillendirilmesidir. Tarihi kaynaklardan elde edilen veriler de bu yöntemlerle tekrar denenerek bilimsel yönden ne kadar geçerli ve güvenilir oldukları net bir şekilde ortaya konulmalıdırÖğe Comparison of the protective effects of silymarin and thymoquinone in the focal cerebral ischemia-reperfusion rat model(Taylor & Francis Ltd, 2024) Solmaz, Merve; Erdogan, Ender; Dasdelen, Dervis; Mogulkoc, Rasim; Vatansev, Husamettin; Akyurek, Fikret; Ozbek, HanefiSilymarin and thymoquinone exert neuroprotective effects, although their combined effects in focal cerebral ischemia/reperfusion (I/R) models are unknown. We compared the effect of silymarin and thymoquinone in an I/R rat model. Wistar rats were divided into five groups: SHAM, REP (I/R), SIR (200 mg/kg silymarin+I/R), TIR (3 mg/kg thymoquinone+I/R), and STIR (200 mg/kg silymarin+3-mg thymoquinone+I/R). The rats underwent bilateral carotid artery occlusion for 30 min and neurological assessments 24 h thereafter. Apoptosis was evaluated using anti-caspase-3 and terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) assays. Astrocyte activation was determined using an anti-GFAP antibody. Total antioxidant status (TAS), total oxidant status (TOS), and trimethylamine N-oxide (TMAO) levels were measured. SHAM and REP rats had the lowest and highest neurological scores, respectively (p = 0.001). REP rats showed greater deterioration than SIR, TIR, and STIR rats. SIR, TIR, and STIR rats had fewer TUNEL and caspase-3-positive cells than REP rats (p<0.05). GFAP expression was higher in REP rats (p<0.05) than in SIR, TIR, and STIR rats (p<0.05). SIR and TIR rats showed higher TAS than REP rats (p<0.05). SIR, TIR, and STIR rats had lower TMAO values than REP and SHAM rats (p<0.05). Silymarin/thymoquinone reduces impairment, apoptosis, and astrocyte activation. Combination therapy reduces TMAO levels.Öğe Curcumin-Impregnated Drug Delivery Systems May Show Promise in the Treatment of Diseases Secondary to Traumatic Brain Injury: Systematic Review(Sage Publications Inc, 2022) Yilmaz, Ibrahim; Karaarslan, Numan; Somay, Hakan; Ozbek, Hanefi; Ates, OzkanObjectiveTo find out whether curcumin can be effective in the treatment of traumatic brain injury (TBI). MethodsA comprehensive and systematic literature search in the PubMed electronic database was performed. Descriptive statistics were used to evaluate the data obtained. The results were presented as frequency and percentage (%) or amount. ResultsTwo clinical trials investigated curcumin for the treatment of TBI. One study tested curcumin in living mammalian subjects using an amyloLipid nanovesicle. In three studies, curcumin was investigated together with the drug delivery system for the treatment of TBI. ConclusionDrug delivery systems prepared with nanomaterials may have a potential therapeutic effect in treating TBI by increasing neuroprotection because they can penetrate the central nervous system more rapidly.Öğe Effect of latanoprost on choroidal thickness in patients with newly diagnosed primary open-angle glaucoma(Kare Publ, 2024) Buyukmurat, Neslihan; Karadag, Erdi; Ozbek, HanefiOBJECTIVE: The purpose of this study was to assess the influence of latanoprost on choroidal thickness in patients with newly diagnosed primary open-angle glaucoma using Swept-Source Optical Coherence Tomography (SS-OCT). METHODS: The retrospective, non-randomized study comprised 40 newly diagnosed primary open-angle glaucoma patients receiving latanoprost therapy (Group 1). Additionally, 40 age- and sex-matched healthy subjects served as the control group (Group 2). Using SS-OCT, measurements of subfoveal, horizontal temporal, and horizontal nasal quadrants choroidal thickness, as well as intraocular pressure (IOP) and retinal nerve fiber layer (RNFL) thickness values, were collected at baseline and after 1 month for both groups. RESULTS: The mean age was 39.8 +/- 4.15 years (range: 18-45 years) in group 1 and 41.67 +/- 7.95 years (range: 18-45 years) in group 2 (p>0.05). The mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant prior to latanoprost therapy were 263.57 +/- 84.23 mu m, 233.05 +/- 80.08 mu m, and 219.52 +/- 83.28 mu m in the group 1 whereas 278.9 +/- 93.88 mu m, 243.8 +/- 73.37 mu m and 209.85 +/- 92.92 mu m in the group 2. After latanoprost therapy, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant changed significantly to 299.77 +/- 41.29 mu m, 269.9 +/- 43.80 mu m, and 261.32 +/- 45.60 mu m in the group 1 (p=0.02, p=0.016, and p=0.012, respectively) (Table 1). However, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant and horizontal nasal quadrant in group 2 changed not significant and was 279.25 +/- 103.37 mu m, 246.42 +/- 87.07 mu m and 203.62 +/- 106.74 mu m, respectively (p=0.4, p=0.5 and p=0.9, respectively). The mean IOP decreased significantly in group 1 (p=0.000) but did not change significantly in group 2 (p=0.153). There was no difference in RNFL thickness values at baseline and 1 st month in group 1 and group 2 (p>0.05). CONCLUSION: Topical latanoprost may increase choroidal thickness. Swept Source-OCT may contribute to our understanding of the actions of latanoprost on choroidal thickness.Öğe Effects of Tocilizumab on Intervertebral Disc Degeneration, Cell Senescence and Inflammation via BMP-2, Hif-1α, IL-1β and SOX9(Asian Network Scientific Information-Ansinet, 2023) Yilmaz, Ibrahim; Akalan, Hande; Sirin, Duygu Yasar; Karaarslan, Numan; Kasim, Emin; Ozbek, Hanefi; Ates, OzkanBackground and Objective: Immunosuppressive tocilizumab (TCZ), which is frequently used in the treatment of rheumatoid arthritis, can have many side effects as well as an uncontrolled inflammatory response. This study aimed to evaluate the effect of tocilizumab (TCZ) administered to intervertebral disc (IVD) tissues in vitro on the proinflammatory cytokines and proteins of degeneration, senescence and inflammation-related signaling pathways at the pharmaco-molecular level. Materials and Methods: Primary cell cultures were prepared using human IVD tissues obtained during lumbar microdiscectomy. Untreated groups served as the control and TCZ-treated groups as the study sample. Analyses were performed using a commercial kit, supravital and fluorescent dyes. Changes in bone morphogenetic protein (BMP)-2, hypoxia-inducible factor (Hif)1-alpha (Hif1-alpha), interleukin (IL)-1 beta (IL-1 beta) and sex-determining region Y (SRY)-box 9 (SOX9) protein expressions were evaluated using western blotting. An alpha value of less than 0.05 was considered significant. Results: Proliferation decreased in the samples treated with TCZ (10 mu g mLG1 ) on day 15 (p<0.05). Protein expressions of BMP-2, Hif-1 alpha, IL-1 beta and SOX9, which play a vital role in anabolic and catabolic pathways, changed in samples treated with TCZ (10 mu g mLG1 ). Conclusion: This change was statistically significant (p<0.05). Therefore, results concluded that the inflammation, extracellular matrix degradation and nucleus pulposus degeneration after disc herniation are controlled by BMP-2, Hif-1 alpha, IL-1 beta and SOX9.Öğe Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats(Briefland, 2022) Koprulu, Rabia Edibe Parlar; Okur, Mehmet Evren; Kolbasi, Bircan; Keskin, Ilknur; Ozbek, HanefiBackground: Diabetes mellitus (DM) is frequently linked with problems of several organ systems, including retinopathy, neuropathy, and nephropathy. Additionally, patients have changes in sexual functioning, such as decreased libido and fertility. Vincamine, a monoterpenoid indole alkaloid, has hypoglycemic and antioxidant effects.Objectives: This research assessed the impact of vincamine on testicular dysfunction in alloxan-induced male rats by measuring fasting blood glucose, oxidative stress, seminal analysis, and histological examination of the testis.Methods: Wister-albino male rats were randomized into the following groups at random: Untreated-healthy, untreated-DM, vincamine-treated (20 mg/kg) DM, vincamine-treated (40 mg/kg) DM, and clomiphene-treated DM (5 mg/kg). On day 14, rats were sacrificed, and semen/blood samples were collected. Sperm count, motility, and morphological abnormalities were noted by microscopic examination. The testis was examined histopathologically and assessed using Johnsen's score.Results: Compared with the untreated diabetic group, a dosage of 40 mg/kg vincamine generate a significant reduction in fasting blood sugar (FBG). Compared with the untreated diabetic group, the vincamine-treated rats produced greater plasma testosterone levels and Johnsen scores. In the vincamine 20 mg/kg group, sperm concentration was higher than in the vincamine 40 mg/kg Conclusions: It is possible that vincamine has a potential preventive effect against diabetes-related reproductive problems attributable to its antioxidant activity and capacity to restore testicular steroidogenesis.Öğe Evaluation of the Effects of HDAC Activity in Hydroxychloroquine Applied Human Primary Chondrocyte and Nucleus Pulposus Cultures(Turkish Neurosurgical Soc, 2025) Kaya, Yasin Emre; Karaarslan, Numan; Yilmaz, Ibrahim; Tamdogan, Tamer; Ondul, Sevim; Yasar Sirin, Duygu; Ozbek, HanefiAIM: To evaluate the in vitro effects of hydroxychloroquine (HCQ) on histone deacetylase (HDAC) enzyme activity and interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-alpha) expressions. MATERIAL and METHODS: Primary cell cultures were prepared. Samples that did not receive any medication constituted the control group, while culture samples treated with HCQ served as the study group. The surface morphology of cells and the extracellular matrix (ECM) were evaluated by Giemsa staining and inverted light microscopy. Cell viability, proliferation, and cytotoxicity were determined by 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium-bromide (MTT) analysis. The cultures were simultaneously stained with acridine orange (AO)/propidium iodide (PI) and viewed under fluorescence microscopy. HDAC enzyme activity and IL-6, IL-10, and TNF-alpha expression were evaluated using commercial enzyme-linked immunosorbent assay kits. The obtained data were analyzed using statistical methods. The alpha significance level was accepted as p<0.05. RESULTS: HCQ applied to cell cultures at the tested doses and durations showed cytotoxic effects on cell viability, proliferation, and cell or ECM morphology. It increased HDAC activity in chondrocytes and caused a proinflammatory response, indicated by an increase in TNF-alpha in the cells (p<0.05). CONCLUSION: The results of this study emphasized that the cytotoxic effect of HCQ increased HDAC activity; therefore, this proinflammatory response should be taken into consideration in the clinical use of HCQ.Öğe HPTLC quantification, assessment of antioxidant potential and in vivo hypoglycemic activity of Scorzonera latifolia (Fisch. & Mey.) DC and its major compounds(Elsevier, 2022) Sonmez, Neriman Ipek Kirmizi; Acıkara, Özlem Bahadır; Sakul, Ayse Arzu; Bahtiyar, Bade Cevriye; Bardakci, Hilal; Barak, Timur Hakan; Ozbek, HanefiScorzonera L. (Asteraceae) species have long been the topic of many phytochemical, analytical, and biological studies since various species of the Scorzonera genus have been widely used as food and medicinal purposes. Apart from its traditional use to relieve pain, promote wound healing, treat helminth infections or women infertility, Scorzonera latifolia (Fisch. & Mey.) DC is also used for its antidiabetic activity. We aimed to investi-gate antidiabetic activity of the aerial parts of the title plant and its major secondary metabolites (hyperoside, isoquercitrin, 7-O-methylisoorientin, isoorientin, swertisin, chlorogenic acid, 4,5-O-dicaffeoylquinic acid and hydrangenol-8-O-b-glucoside) isolated from aerial parts in alloxan-induced diabetic mice. Blood glucose lev-els were measured four times: before the treatment, after 1st, 2nd, and 4th hours of sample treatments (100 mg/kg i.p.). S. latifolia extract displayed notable decline after 4 hours of administration. Among the metabolites; swertisin, 7-O-methyl-isoorientin, and hydrangenol-8-O-b-glucoside were associated with sig-nificant reduction on blood glucose level of alloxan-induced diabetic mice. Due to the strong relationship between oxidative stress and diabetes, antioxidant activity of S. latifolia was additionally tested. Furthermore, 4,5-O-dicaffeoylquinic acid, chlorogenic acid, hyperoside, and swertisin contents as major components of the extract were quantified by HPTLC-densitometry, as their biological effects can be attributed to their phenolic contents. (c) 2022 SAAB. Published by Elsevier B.V. All rights reserved.
