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    Biophysical Overview of Covid-19 Infection
    (2021) Köseler, Aylin; Metin, Damla Anbarlı; Coşkun, Feride Fulya Ercan; Karis, Denizhan
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was declared a global pandemic by WHO on March 11, 2020. Coronavirus disease (COVID-19) is the infectious disease caused by SARS-CoV-2. It is transmitted from person to person through droplets, progresses asymptomatically in 70% of the sufferers, while it may manifest itself in severe clinical conditions, ranging from viral upper respiratory tract infection to pneumonia, sepsis, septic shock, and even acute respiratory distress syndrome (ARDS), in symptomatic patients. Studies on the epidemiological and clinical features of COVID-19 have shown that these patients can develop symptoms of mild or severe acute respiratory infection. In cases with mild symptoms, upper respiratory tract symptoms such as fever, dry cough, and fatigue may develop, and abnormal chest CT findings may also be present. In cases with severe symptoms, dyspnea, diarrhea, severe pneumonia, ARDS or multiple organ failure develop, and mortality rates vary between 4.3% and 15% according to different study reports.
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    Covid-19 Enfeksiyonuna Biyofiziksel Genel Bakış
    (Kafkas Üniversitesi, 2021) Karış, Denizhan; Anbarlı Metin, Damla; Coşkun, Feride Fulya Ercan; Köseler, Aylin
    Şiddetli akut solunum sendromu koronavirüs 2 (SARS-CoV-2) enfeksiyonu, 11 Mart 2020 tarihinde DSÖ tarafından küresel bir pandemi ilan edilmiştir. Koronavirüs hastalığı (COVID-19), SARS-CoV-2’nin neden olduğu bulaşıcı hastalıktır. Damlacık yoluyla kişiden kişiye bulaşan SARS-CoV-2 enfeksiyonu, hastaların %70’inde asemptomatik olarak görülmektedir. Semptomatik hastalarda ise viral üst solunum yolu enfeksiyonundan pnömoni, sepsis, septik şok ve hatta akut solunum sıkıntısı sendromuna (ARDS) kadar değişen ciddi klinik durumlarla seyredebilmektedir. COVID-19’un epidemiyolojik ve klinik özellikleri üzerine yapılan çalışmalarda, bu hastalarının hafif veya şiddetli akut solunum yolu enfeksiyonu semptomları geliştirebileceğini gösterilmiştir. Hafif semptomları olan olgularda ateş, kuru öksürük, yorgunluk gibi üst solunum yolu semptomları gelişebilir ve anormal göğüs BT bulguları da olabilir. Farklı çalışma raporlarına göre, şiddetli semptomları olan vakalarda nefes darlığı, ishal, şiddetli pnömoni, ARDS veya çoklu organ yetmezliği gelişmekte ve ölüm oranları %4,3 ile %15 arasında değişmektedir.
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    A hypertrophic spinal pachymeningitis patient with Factor V Leiden (G1691A), MTHFR C677T, MTHFR A1298C, PAI- 1 4G-5G, Glycoprotein IIIa L33P gene mutations
    (Cureus Inc, 2022) Civlan, Serkan; Harvey, Cemre; Herek, Duygu; Türkçüer, İbrahim; Sabırlı, Ramazan; Pellegrini, Matteo; Köseler, Aylin
    Hypertrophic pachymeningitis (HP) is a rare clinical entity of diverse etiology, characterized by a chronic inflammation that causes dura thickening. Reports of Idiopathic hypertrophic cranial pachymeningitis (IHCP) were related to infections, trauma, tumors, and rheumatologic conditions. It was first described by Charcot and Joffroy regarding spinal meninges in 1869. HP has three stages; progressive radicular symptoms begin first, then muscle weakness and atrophy start. Findings such as paraplegia, loss of bladder and bowel control, and respiratory distress caused by intercostal and diaphragmatic denervation are considered the third stage of the disease. Especially in the cranial form of the disease, nerve ischemia and various cranial neuropathic findings may occur. Factor V Leiden (G1691A), MTHFR C677T, MTHFR A1298C, and PAI-1 4G-5G gene mutation analysis were measured with an ABI Prism. In this case report, the authors present a case of hypertrophic mutations pachymeningitis with Factor V Leiden (G1691A), MTHFR C677T, MTHFR A1298C, PAI-1 4G-5G, Glycoprotein IIIa L33P gene. In conclusion, we report a case of HP with Factor V Leiden (G1691A), MTHFR C677T, MTHFR A1298C, PAI-1 4G-5G, and Glycoprotein IIIa L33P gene mutations. We emphasize that the identification of pachymeningitis can be easily bypassed with the application of limited laboratory techniques. As in this case report, we think that these mutations should be analyzed in patients diagnosed with pachymeningitis.