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  • Küçük Resim Yok
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    CAN BE A PREFERABILITY BETWEEN INDUCTION ANESTHETIC AGENTS FOR FRACTURE SURGERY. HISTOPATHOLOGICAL AND BIOMECHANICAL APPROACH ON RATS
    (World Scientific Publ Co Pte Ltd, 2023) Kuyubasi, Sabit Numan; Inal, Canan; Inal, Sermet; Inal, Mehmet Turan; Deger, Aysenur; Gok, Kadir; Oner, Suleyman Kaan
    As the effect of many medical agents such as nonsteroidal anti-inflammatory drugs or antibiotics were investigated on bone fracture healing, there is no study about the anesthetic agents when compared histopathologically and biomechanically. We asked the question that if a superiority can be between them since we operate many fractures and see the delayed or nonunions. Although different anesthetic agents are used in general anesthesia, the effects of these substances on bone fracture healing are not clear. Here, we intended to research different anesthetic agents on fracture union in rats. The study was done between January 2020 and November 2021 in a university animal research laboratory. Totally 48 male Wistar-Albino rats weighing 250-300g were seperated into 3 groups as Tiyopental Na in Group 1, Ketamin in Group 2 and Propofol in Group 3. For anesthesia; 40, 100, 100mg/kg of single dosages were injected intraperitoneally, respectively. A shaft fracture was created bilaterally to the tibia of all rats. Kirschner (K) wire is used for the fixation of fractures. Biomechanical and histopathological examination in bones is performed at the end of the first and second months in terms of fracture healing. It has been found that the fracture union in group 1 was statistically signifigant higher than group 3 at the end of the first and second months histopathologically (P = 0.006, P = 0.002). It is also found there is a statistically significant difference between groups 1 and 3 after the second month biomechanically (P = 0.013). Although the union was higher in group 1 than group 2 histopathologically and biomechanically after the first and second months, there was no statistically significant difference (P = 0.376, 0.039; P = 0.028, 0.867). There was a general trend in the decrease of union measurements starting from group 1 to 3 at the end of the first and second month both histopathologically and biomechanically. In this study, it is found that there was a positive consistency between histopathological and biomechanical results with respect to bone union. They supported each other. Fracture healing is stronger in rats that were anesthetized by using thiopental than those using ketamine and propofol, we think that this may affect the choice of anesthetic agent and further studies are needed.
  • Küçük Resim
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    Computer aided analysis of biomechanical performance of schanz screw with different additive manufacturing materials used in pertrochanteric fixator on an intertrochanteric femoral fracture (corrosion resistance approach)
    (Wiley, 2023) Gok, Arif; Urtekin, Levent; Gok, Kadir; Ada, H. Deniz; Nalbant, Asrin
    This study examines the use of computer-aided analysis to evaluate the biomechanical performance of Schanz screws made from different additive manufacturing materials (Ti6Al4V, 316 L, Inconel 625, and Inconel 718) in a pertrochanteric fixator for the treatment of intertrochanteric femoral fractures. Intertrochanteric fractures (ITFs) are severe traumas often seen in the elderly population and can lead to serious consequences. The primary objective of ITF surgery is to provide stability and allow for early ambulation and rehabilitation. The Pertrochanteric Fixator is a surgical implant used to treat hip fractures near the greater trochanter, and is attached to the femur with screws. The procedure is performed under general anesthesia and typically takes 1-2 h. Possible complications include infection, nerve injury, and hardware failure. The aim of this study is to evaluate the biomechanical performance of Schanz screw using computer-aided analysis, comparing the effects of various additive manufacturing materials including Ti6Al4V, 316 L, Inconel 625 and Inconel 718 in a pertrochanteric fixator for intertrochanteric femoral fractures. Additionally, this study will also consider the corrosion resistance of these materials to ensure long-term durability and effectiveness in a clinical setting. The stress values mentioned for the implant materials are as follows. Ti6Al4V: 153.33 MPa, 316 L: 180.98 MPa, Inconel 625: 158.94 MPa, Inconel 718: 148.91 MPa. Higher stress values indicate a greater load transfer to the bone, which can potentially lead to stress shielding. Stress shielding occurs when an implant bears a significant portion of the load that should be transferred to the bone. This reduced stress at the fracture site can prevent the healing process, as bones require adequate stress levels for optimal remodeling and regeneration.