Yazar "Gayaf, Mine" seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Antibiotic resistance rates and penicillin MIC distribution in patients with streptococcal pneumonia between 2013-2019, and use of antibiotics in clinical practice(Elsevier, 2022) Anar, Ceyda; Bicmen, Can; Guldaval, Filiz; Atay, Tuba; Gayaf, Mine; Balci, Gunseli; Alici, Ibrahim Onur; Doğan, Betül İkbal; Büyükşirin, Melih; Ayrancı, Aysu; Karadeniz, Gülistan; Polat, GülruPurpose: The purpose of the present study is to investigate the antibiotic resistance rates and use of antibiotics in patients with streptococcal pneumonia in a reference tertiary care hospital for pulmonary diseases in Izmir, Turkey.Methods: A total of 1224 cases with streptococcal pneumonia between 2013 and 2019 were included in the study, retrospectively. Drug susceptibility testing for penicillin and other antibiotics were performed according to the recommendations of EUCAST criteria. Clinical data and general characteristics were collected and evaluated for each patient in accordance with the susceptibility testing report.Results: Totally, resistance rates for trimethophrim-sulfamethoxazole, penicillin (oxacillin), erythromycin, tetra-cycline, clindamycin and levofloxacin resistance were 63.5%, 39.8%, 37.7%, 37.6%, 28.8%, and 4.8%, respec-tively. Antibiotic resistance was not detected against vancomycin,teicoplanin and linezolid. Multidrug resistance rate was found to be 27.1%. It was observed that there was a statistically significant decrease in trimethophrim-sulfamethoxazole, penicillin (oxacillin), erythromycin, clindamycin and levofloxacin resistance rates by years (p: 0.000, 0.004, 0.000, 0.001, 0.010, respectively). The penicillin MIC distribution was higher at the range of 0.12-2 mu g/mL and there was statistical difference among the ranges of MIC values for the representative years (p:0.033). Among the antibiotics investigated, the most commonly used antibiotic was moxifloxacin.Conclusions: Trimethophrim-sulfamethoxazole resistance rate has been found higher than other antibiotics. As penicillin MIC values were at the range of 0.12-2 mu g/mL frequently, high doses of penicillin treatment might be required in some patients. It is noteworthy that significant decrease in resistance rates in penicillin, erythromycin, clindamycin and tetracycline could be due to the vaccination programme carried out since 2008 in Turkey. As the empiric use of quinolones is high it would be more appropriate to use it according to the susceptibility testing. It is important to determine the regional antimicrobial susceptibility for Streptococcus pneumoniae to select appropriate empirical antimicrobials in the clinical practice.Öğe Clinical characteristics and transmission routes of COVID-19 in the early period of the pandemic in a non-covid ward of chest diseases hospital(2021) Karadeniz, Gülistan; Gayaf, Mine; Güldaval, Filiz; Ayrancı, Aysu; Batum, Özgür; Polat, Gülru; Tatar, DursunObjective: In the early stages of the outbreak, Covid patients were followed-up in isolated Covid Wards, and the examinations of other pulmonary diseases continued in Non-Covid wards. Differential diagnosis between COVID-19 and infections caused by other pathogens is not adequately recognized. For this reason, it is even more difficult to identify patients who are infected with SARS-CoV2 or other pathogens. In the present study, the clinical characteristics and transmission routes of the Covid-19 cases in Non-Covid Wards within approximately 2 months’ time after the onset of the pandemic were analyzed speculatively. Method: In the early periods of the pandemic, quarantine wards were created for Covid patients in Chest Diseases Hospital, but there were also changes in Non-Covid patients and new Non-Covid hospitalizations. The clinical characteristics and transmission routes of the Covid cases in Non-Covid Ward were examined retrospectively and observationally between 10.03.2020 and 30.04.2020. Results: During this period, a total of 35 Covid cases were detected as a patient, companion and healthcare employees. The median age of the patients was 50 years (min-max 25-85). There were 17 patients (48.6%) who were not severe, and 18 severe patients (51.4%), and 10 (28.6%) patients died. A total of 25 (71,4%) of infected cases were verified with the SARS-CoV-2 Nucleic Acid Test, and 10 (28,6%) were diagnosed clinically and radiologically as possible COVID-19 cases. Being 65 years old or over, having comorbid diseases, especially COPD, the presence of dyspnea as a symptom and involvement on chest radiography were found to be significantly associated with survival (p0.027, 0.009, 0.038, 0.000 and 0.033, respectively). Lymphopenia, increase in neutrophil count, CRP and NLR value were found to be statistically related to survival (p 0.005, 0.001, 0.014 and 0.000, respectively). We found 4 super spreaders, one of whom was a companion, and 3 patients. Conclusion: Potential “super spreaders” can be the source of infection before the quarantine conditions are applied and comprehensive protection is implemented. For this reason, quarantine, use of personal protective equipment, application of social distancing, and the implementation of comprehensive preventive measures, such as disinfection, are crucial in controlling nosocomial infection.Öğe Effect of host risk factors in identifying mortality in COVID-19 pneumonia and a new COVID-19 mortality index: Co-AMSCA(Kare Publ, 2022) Gayaf, Mine; Anar, Ceyda; Polat, Gülru; Ayrancı, Aysu; Güldaval, Filiz; Karadeniz, Gülistan; Batum, ÖzgürBACKGROUND AND AIM: The purpose of the study was to examine the host risk factors related to mortality in patients hospitalized with coronavirus disease 2019 (COVID-19) pneumonia and to find a COVID-19 mortality score based on these factors. METHODS: Subjects hospitalized with COVID-19 pneumonia between March 11, 2020, and October 1, 2020, were retrospectively analyzed. The age, gender, smoking status, body mass index, blood group, severity of pneumonia, comorbidity, reverse transcriptase-polymerase chain reaction positivity, use of angiotensin-converting enzyme (ACE) inhibitors, radiological changes, and mortality rates of the patients who had proven COVID-19 pneumonia were recorded. Patients were divided into two groups according to mortality status, and the two groups were compared. The cutoff values, sensitivity and specificity values, and odds ratios were calculated to predict mortality of the new scoring system. RESULTS: A total of 422 patients (51 mortal and 371 nonmortal) participated in the study. The univariate regression analysis showed that age, male gender, smoking, comorbidity, and using ACE inhibitors were prognostic host risk factors for COVID-19-related mortality. A new scoring model with the combination of risk factors named Co-AMSCA was created in the study. The cutoff value of the system was found to be 3.5 with 88.4% sensitivity and 65.5% specificity. The mortality risk in patients with a Co-AMSCA mortality score above 3.5 points was 7.8 times higher than that in patients whose score was lower than 3.5 points. In multivariate logistic regression analysis, older age and smoking were significant risk factors for mortality. CONCLUSIONS: A mortality score was created based on host risk factors, which are easy to calculate and do not need laboratory tests and do not waste the time of the clinicians. This study showed that by using Co-AMSCA scoring model, it is possible to achieve a mortality prediction in COVID-19 patients who are hospitalized due to pneumonia.Öğe Evaluation of whether smoking cessation among advanced lung cancer patients has a significant effect on anxiety and depressive symptoms(Kare Publ, 2023) Guldaval, Filiz; Polat, Gulru; Anar, Ceyda; Ayranci, Aysu; Karadeniz, Gulistan; Gayaf, Mine; Turk, Merve AyikBACKGROUND AND AIM: Continued smoking has a detrimental effect on lung cancer patients, which may already be associated with anxiety and depression. There is a belief among some that smoking cessation will further increase anxiety and depression in these patients, reducing their quality of life. In this study, we aimed to determine whether there was a difference in anxiety, depression, and quality of life scores between ex-smokers after the diagnosis of lung cancer and current smokers.METHODS: One hundred patients with advanced lung cancer were included in the study. Demographic characteristics were recorded, and the smoking status of patients was questioned. The Hospital Anxiety and Depression Scale and European Organization for Research and Treatment of Cancer Quality of Life tests were performed to evaluate anxiety, depression, and quality of life.RESULTS: The mean age was 61 & PLUSMN;8 years. Adenocarcinoma was the most common type of cancer, and 64% of the cases were at stage 4. Of the total 100 patients, 8 had never smoked, 23 were smokers, and 69 were ex-smokers. After the diagnosis of lung cancer, 17 patients quit smoking. No statistically significant difference was found between smoking status and anxiety or depression and quality of life scores (p>0.05). There was no difference between anxiety or depression and quality of life scores between patients who quit smoking after the diagnosis and those who continued (p>0.05).CONCLUSIONS: Patients with lung cancer should not be abstained from smoking cessation because of the possibility of increased anxiety or depression; rather, patients should be supported for smoking cessation at any stage.Öğe Sociodemographic and clinical risk factors associated with in-hospital tuberculosis mortality in Turkiye, 2008-2018(Turkish Assoc Tuberculosis & Thorax, 2024) Gayaf, Mine; Ayik Turk, Merve; Ozdemir, Ozer; Polat, Gulru; Karaman, Onur; Guldaval, Filiz; Ari, GulsumIntroduction: Tuberculosis (TB) is an infectious disease that can be fatal if left untreated or poorly treated, and it is associated with many morbidities. Deaths may provide better understanding of the associated factors and help guide interventions to reduce mortality. In this study, it was aimed to reveal some of the features that predict hospital mortality in patients with TB and to present some alarming findings for clinicians. Materials and Methods: Patients who had been hospitalized with the diagnosis of TB between January 2008 and December 2018 were included and analyzed retrospectively. In -hospital mortality because of any TB disease after the initiation of treatment in patients admitted to the TB Ward and the primary cause of mortality were taken as endpoint. Results: A total of 1321 patients with a mean age of 50.1 years were examined. Total mortality was 39.4% (521 deaths) and 13.1% were in -hospital deaths (173 deaths). Of the deaths, 61.8% (n= 107) occurred during the first month after TB treatment were started. On univariate analysis, age over 48.5 years, Charlson comorbidity index, extension of radiological involvement, hypoalbuminemia and lymphopenia were most predictive variables with higher odds ratios (respectively, p< 0.001 for all). Conclusion: In -hospital tuberculosis disease mortality is related with older age, cavitary or extensive pulmonary involvement, low albumin levels, unemployment, cigarette smoking and especially those with concomitant malignancy and chronic pulmonary disease.
