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    Öğe
    Does heated erythrocyte suspension transfusion with medical devices containing phthalates increase DEHP and MEHP levels?
    (Wiley, 2021) Gönüllü, Edip; Bilvanisi, Sevdegul; Tasdogen, Aydin; Gönüllü, Hayriye; Erkin, Yüksel; Kume, Tuncay; Aykac, Mehmet Coşkun
    Aims It is commonly known that stored blood and blood products are heated before transfusion to prevent hypothermia, which leads to increased di-(2-ethylhexyl) phthalate (DEHP) content leaching into the blood and blood products and thereby causes greater conversion of DEHP to mono (2-ethylhexyl) phthalate (MEHP). However, there has been no study in the literature reporting on the amount of toxic phthalates in blood following the erythrocyte suspension (ES) transfused via warming. In this study, we aimed to investigate the DEHP and MEHP content in blood following the heated ES transfusions administered by DEHP-containing and DEHP-free infusion sets. Methods The study included 30 patients that were randomly divided into two groups with 15 patients each: group I underwent ES transfusion via DEHP-containing infusion sets warmed with blood-fluid warmers, and group II underwent ES transfusion via DEHP-free infusion sets warmed with blood-fluid warmers. DEHP and MEHP levels were measured both before and after transfusion. Results DEHP-free infusion sets led to no increase in the phthalate content, whereas DEHP-containing infusion sets significantly increased the DEHP and MEHP, where the DEHP level increased almost four times (P = .001). Conclusion DEHP-containing products lead to toxicity. Therefore, using DEHP-free medical devices may prevent toxicity in patients undergoing ES transfusion.
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    Öğe
    Herbal Product/Drug Usage Habits of Patients Applying to the Pain Clinic
    (2023) Özduran, Erkan; Erkin, Yüksel; Hancı, Volkan; İyilikci, Leyla; Gönüllü, Edip; Tertemiz, Oktay Faysal; Kara, Müge Mercan
    Aim: In recent years, the use of herbal products and drugs has been increasing all over the world. During irrational use, herbal product-drug interaction and side-effect rates also pose a risk. The aim of this study is to evaluate the effects of patients on herbal/product drug use habits and other sociodemographic characteristics by gender during their application to the Pain (Algology) outpatient clinic. Methods: In this cross-sectional study, which was created by using face-to-face questionnaire method on 200 patients between February and June 2022, after ethics committee approval, the herbal product/drug use habits and sociodemographic characteristics of the participants were questioned. Results: 71.5% of the participants were female and 28.5% were male. 29% of the participants were using herbal products. There was no significant relationship between the use of herbal products by gender (p = 0.419). It was determined that the users most frequently (32.8%) used these products to strengthen the immune system. It was determined that 36.2% of the users had knowledge about side effects and there was a significant difference between gender and knowledge about side effects (p = 0.035). Conclusions: It was determined that 29% of the patients used herbal products and the most frequently used herbal product was cinnamon. There was no significant relationship between the use of herbal products and gender. It has been determined that patients most frequently get advice from doctors about the use of herbal products, and the most common reason for using them is to strengthen the immune system. It is important for health care providers to have knowledge about herbal products and to question patients about possible herb-drug interaction