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    The importance of procalcitonin in the diagnosis and prognosis of patients with dyspnea in the emergency department Is procalcitonin gold standart in pneumonia?
    (Bayrakol Medical Publisher, 2021) Erdoğan, Arife; Bora, Ejder Saylav; Kokkoz, Çağrı; Erdoğan, Mümin Alper; Elmalı, Ferhan
    Aim: Dyspnea is a common problem in emergency services worldwide. Bacterial pneumonia is a common etiology in patients with acute dyspnea causing mor-bidity and mortality. Early initiation of appropriate antibiotic therapy reduces mortality. However, it is difficult to diagnose pneumonia with symptoms similar to acute heart failure and acute exacerbation of chronic obstructive pulmonary disease, and without definitive diagnostic testing. For this, it is thought that the use of a biomarker that can diagnose pneumonia at the time of admission to the hospital would be clinically useful. Material and Methods: Patients who came to the emergency department with shortness of breath were analyzed retrospectively. Three hundred patients were examined. Serum procalcitonin values of patients diagnosed with pneumonia by chest radiography or thorax CT were compared with other patients. Patients discharged from the emergency department or hospitalized were classified as a good clinical outcome group, patients who were intubated, in need of intensive care, or who died were classified as a poor clinical outcome group, and procalcitonin values were compared. The data were evaluated using the SPSS Statistics Standard statistical package program. A p <0.001 value was considered statistically significant. Results: In patients presenting with dyspnea, pneumonia (150), COPD exacerbation (30), lower respiratory tract infection (LRTI) (18), acute coronary syndrome (ACS) (27), and acute heart failure (AHF) (76) were diagnosed. The PCT values of the patients diagnosed with pneumonia were significantly higher than the other groups (p <0.001). In terms of white blood cell (WBC) values, there was no significant difference between pneumonia patients and other patients. When the neutrophil-lymphocyte ratio (NLR) was examined, it was found to be significantly higher in pneumonia patients (p <0.001). When we examined the progno-sis of pneumonia patients, the PCT values of the patients with a poor prognosis were found to be significantly higher (p <0.001). Discussion: We have seen that PCT has an important role in the diagnosis and prognosis of pneumonia in patients admitted to the emergency department with shortness of breath.
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    Machine Learning for E-triage
    (SET Teknoloji, 2022) Bora, Şebnem; Kantarcı, Aylin; Erdoğan, Arife; Beynek, Burak; Kheibari, Bita; Evren, Vedat; Erdoğan, Mümin Alper
    Due to the rising number of visits to emergency departments all around the world and the importance of emergency departments in hospitals, the accurate and timely evaluation of a patient in the emergency section is of great importance. In this regard, the correct triage of the emergency department also requires a high level of priority and sensitivity. Correct and timely triage of patients is vital to effective performance in the emergency department, and if the inappropriate level of triage is chosen, errors in patients' triage will have serious consequences. It can be difficult for medical staff to assess patients' priorities at times, therefore offering an intelligent method will be pivotal for both increasing the accuracy of patients' priorities and decreasing the waiting time for emergency patients. In this study, we evaluate the machine learning algorithms in triage procedure. Our experiments show that Random Forest approach outperforms the others in e-triage.
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    Protective effect of polyethylene glycol (PEG) 3350 on a cisplatin-induced rat model of neuropathy
    (Asian Network Scientific Information-Ansinet, 2022) Gönüllü, Edip; Dağıstan, Gözde; Erdoğan, Mümin Alper; Erbaş, Oytun
    Background and Objective: Peripheral neuropathy is the most important side effect, leading to a decrease in the dose of cisplatin or its complete cessation in the early period. For this purpose, the study aimed to investigate the therapeutic potential of PEG in cisplatin-induced neuropathy and to measure the levels of MDA, GSH, IL-6 and TNF-alpha, which are key markers of lipid peroxidation and antioxidant capacity. Materials and Methods: Cisplatin was given to 16 rats twice a week for 4 weeks at a rate of 2.5 mg/kg/day. Cisplatin-treated rats were split into two groups. For 4 weeks, the rats in Group 1 (n = 8) received 1 mL/kg/day of 0.9% NaCl intraperitoneally, while the rats in Group 2 received 30 mg/kg/day of PEG. The control group consisted of the eight surviving rat specimens. The motor abilities of all the animals were assessed after the research. Blood samples were collected for the measurement of plasma lipid peroxidation malondialdehyde (MDA), Tumour Necrosis Factor (TNF-alpha), glutathione (GSH) and IL-6 levels. Results: Electromyography findings revealed that compound muscle action potential (CMAP) amplitude was significantly higher in the cisplatin-PEG group than in the cisplatin-saline group. Also, cisplatin-PEG treated group showed significantly lower TNF-alpha, MDA and IL-6 levels and hig her GSH levels than the cisplatin-saline group (p<0.01, p<0.001). In addition, while the CMAP latency was decreased in the PEG-treated group, the CMAP amplitude was increased and a significant improvement was observed in the Inclined test scores. Besides, histological examinations showed an increase in axon diameter and NGF expression with PEG treatment. Conclusion: This study demonstrated that PEG exerts protective activity against cisplatin-induced neurotoxicity by increasing endogenous antioxidants and reducing lipid peroxidation and inflammation.