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Öğe AGK-2 Protects the Tymus Aganist D-Galactose Induced Senescense in Rats(Wiley, 2023) Bahar, Asli Nur; Kavak, Hatice; Keskin-Aktan, Arzu; Dizakar, Saadet Ozen Akarca; Coskun, Ayca; Akbulut, Kazime Gonca[Abstract Not Available]Öğe Comparison of the effects of recombinant human epidermal growth factor (rhEGF) and alendronate sodium on tibial fracture healing in rats: an experimental study(Cukurova Univ, Fac Medicine, 2024) Tepedelenlioglu, Huseyin Emre; Abduelaliyev, Ferid; Ahmadov, Asim; Dizakar, Saadet Ozen Akarca; Ozogul, Candan; Esen, ErdincPurpose:The objective of this study is to compare the effects of recombinant human epidermal growth factor (rhEGF) on bone healing with those of alendronate, a bisphosphonate widely used in practice.Materials and Methods:An iatrogenic fracture was created in the tibial shaft of 24 Sprague-Dawley rats with osteotome and fixed with an intramedullary Kirschner wire (K-wire). After surgery, Group 1 was given 0.2 mg/kg/day of oral alendronate sodium on postoperative Day 1 to 28, Group 2 received a single dose of 0.5 mg/kg of intraosseous rhEGF on postoperative Days 1 and 14, and Group 3 was followed for a total of four weeks with oral saline. At the end of Week 4, the animals were euthanized and the lower extremities were removed by stripping the soft tissues without damaging the callus. Tissue samples of groups were prepared and and stained with hematoxylin-eosin. After staining, histological scoring was performed to evaluate the degree of union.Results: Alendronate sodium group demonstrated a mean histological score of 6.95 +/- 1.28. The rhEGF group had a lower mean score of 4.85 +/- 1.66. The placebo group exhibited the least progress in bone healing with a mean score of 4.10 +/- 1.68. The histological score was significantly higher in the alendronate sodium group compared to both the rhEGF and placebo groups. There was also a statistically significant difference between the rhEGF and placebo groups in terms of scores. Conclusion: Alendronate sodium enhanced fracture healing processes in rats. The role of rhEGF in bone healing requires further exploration. As the understanding of bisphosphonates and growth factors in bone healing evolves, the strategies for optimizing patient care in orthopedic settings are expected to be developed.Öğe Effect of SIRT2 Inhibition on Developing Fibrosis in D-GalactoseInduced Aging Model(Wiley, 2023) Bahar, Asli Nur; Aktan, Arzu Keskin; Sonugur, Fatma Gizem; Dizakar, Saadet Ozen Akarca; Akbulut, Kazime Gonca[Abstract Not Available]Öğe Investigation of healing strategies in a rat corneal opacity model with polychromatic light and stem cells injection(Elsevier Science Sa, 2024) Uysal, Betul Seher; Sarikaya, Burcu; Dizakar, Saadet Ozen Akarca; Kaplanoglu, Gulnur Take; Gumusderelioglue, MenemseCorneal opacities are a major cause of vision loss worldwide. However, the current therapies are suboptimal to manage the corneal wound healing process. Therefore, there is an obvious need to develop new treatment strategies that are efficient in promoting wound healing in patients with severe corneal disorders. In this study, we investigated and compared the efficacy of adipose-derived mesenchymal stem cells (ADMSCs) and photobiomodulation (PBM) with polychromatic light in the NIR (600-1200 nm) alone and in combination, on corneal opacity, inflammatory response, and tissue architecture in a rat corneal opacity model created by mechanical injury. All animals were divided into four groups randomly following the injury: injury only (no treatment), ADMSCs treatment, PBM treatment and combined (ADMSCs+PBM) treatment (n = 12 eyes per group). At the 10th and 30th day following injury, corneal opacity formation, neovascularization, and corneal thickness were assessed. On the 30th day the harvested corneas were analyzed by transmission electron microscopy (TEM), histological evaluation, immunohistochemical (IHC) staining and real-time polymerase chain reaction (RT-PCR). On day 30, the corneal opacity score, neovascularization grade, and corneal thickness in all treatment groups were significantly lower in comparison with the untreated injured corneas. The TEM imaging and H&E staining together clearly revealed a significant enhancement in corneal regeneration with improved corneal microenvironment and reduced vascularization in the combined administration of PBM and ADMSCs compared to treatment of PBM and ADMSCs alone. In addition, the IHC staining, and RT-PCR analysis supported our hypothesis that combining ADMSCs therapy with PBM alleviated the inflammatory response, and significantly decreased scar formation compared to either ADMSCs or PBM alone during the corneal wound healing.Öğe Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin(Springer Int Publ Ag, 2024) Bugdayci, Azimet Yalcin; Dizakar, Saadet Ozen Akarca; Demirel, Muerside Ayse; Omeroglu, Suna; Akar, Fatma; Uludag, Mecit OrhanBackground It has been reported that High-Fructose (HF) consumption, considered one of the etiological factors of Metabolic Syndrome (MetS), causes changes in the gut microbiota and metabolic disorders. There is limited knowledge on the effects of metformin in HF-induced intestinal irregularities in male and female rats with MetS. Objectives In this study, we investigated the sex-dependent effects of metformin treatment on the gut microbiota, intestinal Tight Junction (TJ) proteins, and inflammation parameters in HF-induced MetS. Methods Fructose was given to the male and female rats as a 20% solution in drinking water for 15 weeks. Metformin (200 mg/kg) was administered by gastric tube once a day during the final seven weeks. Biochemical, histopathological, immunohistochemical, and bioinformatics analyses were performed. Differences were considered statistically significant at p < 0.05. Results The metformin treatment in fructose-fed rats promoted glucose, insulin, Homeostasis Model Assessment of Insulin Resistance Index (HOMA-IR), and Triglyceride (TG) values in both sexes. The inflammation score was significantly decreased with metformin treatment in fructose-fed male and female rats (p < 0.05). Moreover, metformin treatment significantly decreased Interleukin-1 Beta (IL-1 beta) and Tumor Necrosis Factor-Alpha (TNF-alpha) in ileum tissue from fructose-fed males (p < 0.05). Intestinal immunoreactivity of Occludin and Claudin-1 was increased with metformin treatment in fructose-fed female rats. HF and metformin treatment changed the gut microbial composition. Firmicutes/Bacteroidetes (F/B) ratio increased with HF in females. In the disease group, Bifidobacterium pseudolongum; in the treatment group, Lactobacillus helveticus and Lactobacillus reuteri are the prominent species in both sexes. When the male and female groups were compared, Akkermansia muciniphila was prominent in the male treatment group. Conclusion In conclusion, metformin treatment promoted biochemical parameters in both sexes of fructose-fed rats. Metformin showed a sex-dependent effect on inflammation parameters, permeability factors, and gut microbiota. Metformin has partly modulatory effects on fructose-induced intestinal changes.Öğe Protective Effect of Sirtuin 2 Inhibition in D-Galactose-Induced Renal Aging and Fibrosis(Wiley, 2023) Keskin-Aktan, Arzu; Bahar, Asli Nur; Dizakar, Saadet Ozen Akarca; Akbulut, Kazime Gonca[Abstract Not Available]Öğe The Role of Adropin in Metabolic Syndrome and Cardiac Remodeling(Wiley, 2023) Yesil, Ahmet Hulusi; Ozer, Cigdem; Dizakar, Saadet Ozen Akarca[Abstract Not Available]Öğe The Effect of Calorie Restriction on Testicular Tissue During Aging Process(Wiley, 2025) Toker, Esra; Coskun, Ayca; Aktan, Arzu Keskin; Dizakar, Saadet Ozen Akarca; Akbulut, Kazime Gonca[No abstract available]Öğe The Effect of Calorie Restriction on Testicular Tissue During Aging Process -2(Wiley, 2025) Toker, Esra; Coskun, Ayca; Aktan, Arzu Keskin; Dizakar, Saadet Ozen Akarca; Akbulut, Kazime Gonca[No abstract available]
