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    Ceftazidime-Avibactam Susceptibility of Klebsiella pneumoniae Isolates Obtained from Intensive Care Patients
    (2023) Senol, Gunes; Demirel, Mahmut Mete; Gunduz, Ayriz Tuba; Akan, Tuba; Bicmen, Can; Yildirim, Suleyman
    Objective: Antibiotic resistance encountered in agents causing intensive care unit (ICU) infections is a considerable problem in treatment. In recent years, multiple antibiotic resistances have been detected, especially in Klebsiella pneumonia iso- lates. Infections caused by these bacteria are difficult to handle and have a high mortality. In this study, the in vitro antimicrobial susceptibility rate of ceftazidime/ avibactam (CAZ-AVI). on K. pneumonia isolates obtained from the samples of ICU patients was investigated. Material and Methods: The study is designed as a cross-sectional cohort. CAZ-AVI susceptibility of K. pneumonia isolates obtained from patients diagnosed with ICU infection was studied by disc diffusion method. Results: Among 37 K. pneumonia isolates isolated from 20 blood, 16 bronchial aspi- rate and one urine samples from ICU patients, 31 (83.7%) were found to be CAZ-AVI susceptible and 6 (16.3%) were resistant. 12 of the isolates are panresistant. It was observed that 3 (25%) of the panresistant strains were resistant to CAZ-AVI and 9 (75%) were susceptible. Conclusion: In our study, it was determined that CAZ-AVI showed a low resistance rate even in K. pneumoniae strains that showed multi-antibiotic resistance. It was thought that it could be an alternative treatment option in ICU infections with antibiotic resistance problems.