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  • Küçük Resim
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    Evaluation of antidiabetic activities of scorzonera species on alloxan induced diabetic mice
    (Marmara Univ, Inst Health Sciences, 2021) Şakul, Ayşe Arzu; Kurtul, Ekin; Özbek, Hanefi; Kırmızı, Neriman Ipek; Bahtiyar, Bade Cevriye; Saltan, Hayriye; Acıkara, Özlem Bahadır
    Objective: In Turkish folk medicine, different species of Scorzonera (Asteraceae) have been used in the treatment of various disorders. The study aimed to investigate antidiabetic activity of Scorzonera species and if rutin is the primary component responsible of this activity. Methods: The extracts of aerial parts of Scorzonera tomentosa, S. mollis ssp. szowitsii, S. suberosa ssp. suberosa, S. eriophora, S. acuminata, S. sublanata and S. cana var. jacquiniana were used in the experiment. Additionally, rutin, which has been analysed and detected by using HPLC qualitatively and quantitatively in some Scorzonera species, was also tested for its antidiabetic activity in the same conditions. An alloxan-induced diabetic mice test model was used in order to verify antidiabetic activity. Antidiabetic activities of the 9 groups (n=5; each) were measured at four different times: before Scorzonera extracts and rutin treatment and after 1, 2 and 4 hours of treatments. Results: S. sublanata extract exhibited the highest antidiabetic activity and at 100 mg/kg dose, it significantly reduced blood glucose levels measured after 1, 2 and 4 hours of treatments when compared to isotonic saline solution group (diabetic control group). S. cana var. jacquiniana extract also displayed notable decrease after 4 hours of treatment. Significant lowering effect on blood glucose level was also observed by treatment with rutin in all tested times at 100 mg/kg i.p. injection. According to the HPLC analyses the highest rutin content was determined in the S. acuminata aerial parts. Conclusion: Rutin content and the antidiabetic activity of the plant extracts were not correlated as displayed in this present study. Further studies should be performed to reveal responsible compunds for antidiabetic activity.
  • Küçük Resim
    Öğe
    İlaç ve gıda takviyelerinin içerikleri hakkında kullanıcıların bilgi ve talep düzeyinin ölçülmesi
    (Refik Saydam National Public Health Agency (RSNPHA), 2022) Özcan, Vildan; Şakul, Ayşe Arzu; Özbek, Hanefi
    Objective: When the medicine leaflets of drugs and food supplements are examined, it is seen that the contents are not fully reflected to the user. For this reason, the person who will use drugs or food supplements does not have the opportunity to access reliable information about whether there is a substance in their content that is not suitable for their own belief and culture; even if he wishes for such a thing, he cannot reach sufficient information about where to access this information. The information on the Internet, on the other hand, presents an information pollution appearance that lacks scientific competence in general and has not been adequately audited. The aim of this study is to determine the opinions and preferences of the users regarding the transparency of the contents of pharmaceutical and food supplement products in line with their own needs. Methods: The sample of the study was made by 888 prescribers who applied to pharmacists, and the answers given to the questionnaire with 16 questions gave the results of the study. The data were evaluated by descriptive and analytical statistical methods. Results: Participants consisted of volunteers with an average age of 40.05, 92.9% living in cities or big cities, and 62.2% women. The educational level of the participants was 54.9% primary education and 43.2% higher education. When 33.2% of volunteers used medication at least once a day or week, 66.8% stated that they sick or rarely used medication. When 92.7% of the participants read the medicine leaflet or read the medicine leaflet whenever necessary, 92.7% of the participants thought that they should inform the physician or pharmacist about the contents of the drugs, 44.5% of the drug the health professions were informed about it. 94.8% of the volunteers wanted to know whether they were addictive substances in medicines or food supplements, a substance that could cause allergic reaction, alcohol or pigs, 80.8% of the participants would search for alternative ways, 10.8% he would deny the treatment. Conclusion: IIt was concluded that patients wanted the information showing the contents of medicines or food supplements to enter the pamphlets to reflect the requirements of their religious beliefs. Considering this issue while preparing the medicine leaflets has been considered as an issue that needs to be taken into account both in terms of patient rights and consumer rights © 2022. Turk Hijyen ve Deneysel Biyoloji Dergisi.All Rights Reserved.