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    Adli Yaş Tahminine Yönelik Web of Science Veritabanında Yer Alan Araştırma Çalışmaların Bibliometrik Analizi
    (2023) Ayvat Öcal, Zeynep; Bakıcı, Rukiye Sümeyye; Meral, Orhan; Öner, Zülal; Öner, Serkan
    Amaç: Günümüzde yaş tahmini, biyolojik profil oluşturulmasında yararlanılan, adli bilimlerde kim-liklendirme amacıyla sıklıkla kullanılan ve önemli veriler sunan bir yöntemdir. Bu çalışmanın amacı, ISI Web of Knowledge-Science veritabanında yer alan yaş tahmini konusundaki eserlerin biblio-metrik analizini yaparak, disiplinler arası etkileşim ve araştırma trendlerini belirlemeye yönelik öneriler sunmaktır. Materyal ve metod: WoS veritabanında yer alan eserler arasından başlığında \"age\" sözcüğü ve bunun yanı sıra “estimation”, “determination”, “prediction” veya “assessment” sözcüklerinden herhangi birini içeren makaleler tespit edilmiştir. Veritabanının filtreleme özelliğinden yararlanılarak bu makalelerin yazım dili, yayın yılı, yayınlandığı dergi, makalenin yazarları, yazar kurumları, çalışmala-rın yapıldığı ülke ve makalelere yapılan atıf sayısı ile çalışmaların finansal destek alıp almadığı araştı-rıldı. Bulgular: -Çalışmamız kapsamını oluşturan 1020 makalenin, (n=990,%97.1) kadarının İngilizce olarak yayınlandığı, eserlerin yayınlandığı günden bugüne toplam 23704 atıf aldığı, incelenen makalelerin (n=993,%97.4) kadarının SCI-E kapsamında indekslenen dergilerde yer aldığı ve en çok çalışmanın (n=145, %10.4) makale ile Almanya’da yapıldığı bilgisine ulaşıldı. Sonuç: Çalışma verileri, WoS veritabanında yer alan makalelerin analiz edilmesi sonucu elde edilen veriler ışığında ülkeler, kurumlar ve araştırmacıların adli yaş tahmini konusundaki bibliometrik analizini ortaya koymaktadır. Sunulan çalışma, bu alanda yapılan ilk çalışma niteliğindedir. Elde edilen bilgiler araştırmacılar, akademisyenler ve diğer paydaşlar için değerli bir kaynak olabilir ve gelecekteki yaş tahmini araştırmalarının yönlendirilmesine katkı sağlayabilir.
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    Age estimation using machine learning algorithms with parameters obtained from X-ray images of the calcaneus
    (Wolters Kluwer Medknow Publications, 2024) Ciftci, R.; Secgin, Y.; Oner, Z.; Toy, S.; Öner, Serkan
    Background:Determination of bone age is a critical issue for forensics, surgery, and basic sciences.Aim:This study aims to estimate age with high accuracy and precision using Machine Learning (ML) algorithms with parameters obtained from calcaneus x-ray images of healthy individuals.Method:The study was carried out by retrospectively examining the foot X-ray images of 341 people aged 18-65 years. Maximum width of the calcaneus (MW), body width (BW), maximum length (MAXL), minimum length (MINL), facies articularis cuboidea height (FACH), maximum height (MAXH), and tuber calcanei width (TKW) parameters were measured from the images. The measurements were then grouped as 20-45 years of age, 46-64 years of age, 65 and older, and age estimation was made by using these at the input of ML models.Results:As a result of the ML input of the measurements obtained, a 0.85 Accuracy (Acc) rate was obtained with the Extra Tree Classifier algorithm. The accuracy rate of other algorithms was found to vary between 0.78 and 0.82. The contribution of parameters to the overall result was evaluated by using the shapley additive explanations (SHAP) analyzer of Random Forest algorithm and the MAXH parameter was found to have the highest contribution in age estimation.Conclusions:As a result of our study, calcaneus bone was found to have high accuracy and precision in age estimations.
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    Analysis of the correlation between thyroid hormones and thyroid volume by gender: A volumetric computed tomography study
    (2022) Öner, Zülal; Öner, Serkan; Secgin, Yusuf; Toy, Şeyma
    The aim of this study was to evaluate the correlation between triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) hormones and thyroid gland volume with volumetric analysis performed by using computed tomography (CT) images. In this retrospective study, IV contrasted thoracic CT images taken for different indications between 2019 January and 2020 January were scanned from the archive system of the hospital. 67 (31F, 36M) individuals chosen randomly among patients whose CT results were reported as normal and who had taken thyroid hormone tests within the past week were included in the study. Images in Digital Imaging and Communications in Medicine format were transferred to the personal work station program (Horos Medical Image Viewer). By using the Region of Interest (ROI) console in the current program, a three dimensional model was obtained by drawing the border of the thyroid gland in sections varying between 15 and 25. Volume values of this three-dimensional model and TSH, T3, T4 values of the individuals were compared. While no correlation was found between thyroid gland volume and T3 and T4 hormones, a negative significant correlation was found with TSH. In terms of gender, thyroid gland volume, T3, T4 values were found to be statistically significantly higher in women when compared with men (p?0.05). TSH value was found to be higher in women when compared with men (p=0.005). No statistically significant difference was found in T4 value (p=0.057). Radio-anatomical volumetric data of the thyroid gland presented in this study and its correlation with thyroid functions will be beneficial to clinicians working in the field in both internal and surgical medicine branches and will also guide future studies.
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    Bilgisayarlı Tomografi Görüntüleri Üzerinden Hesaplanan Tibia Parametrelerinin Yaş ve Cinsiyete Göre Değerlendirmesi
    (Karabük Üniversitesi, 2024) Emiroğlu, Muhammed; Toy, Şeyma; Seçgin, Yusuf; Öner, Serkan
    Amaç: İnsan kalıntılarından kemikler kompakt yapılarından dolayı doğada uzun süre korunur ve bu durum kimliklendirmede kullanışlı olmalarını sağlar. Dimorfizm gösterdiği bilinen kemikler olsa da tibia ve femur erozyona karşı ciddi derecede dirençli olmaları dolayısı ile yaş ve cinsiyet değerlendirmelerinde kullanılabilir. Bu çalışmanın amacı bilgisayarlı tomografi (BT) görüntüleri üzerinden hesaplanan tibia parametrelerinden yaş ve cinsiyetin değerlendirmesidir. Gereç ve yöntem: Bu çalışma 2015-2022 yılları arasında 114 bireye ait alt ekstremite BT anjio görüntülerinin retrospektif olarak incelenmesi ile gerçekleştirildi. Bireyler 30-40 (1. yaş grubu), 41-50 (2. yaş grubu), 51-60 (3. yaş grubu) yaş gruplarına ayrıldı. Görüntüler DICOM formatında Radiant DICOM Viwer programına aktarıldı ve tibia üzerinden Sağ condylus medialis ile lateralis arası uzunluk (CML-RL), Sol condylus medialis ile lateralis arası uzunluk (CML-LL), Sağ tibianın ortasında corpus tibia genişliği (CT-RW), Sol tibianın ortasından corpus tibia genişliği (CT-LW), Sağ condylus medialis-malleolus medialis arası uzaklık (CMMM-RL), Sol condylus medialis-malleolus medialis arası uzaklık (CMMM-LL), Sağ condylus lateralis-malleolus lateralis arası uzaklık (CLML-RL), Sol condylus lateralis-malleolus lateralis arası uzaklık (CLML-LL), Sağ malleolus medialis-tuberositas tibia-malleolus lateralis arası açı (MMTML-RA), Sol malleolus medialis-tuberositas tibia-malleolus lateralis arası açı (MMTML-LA) parametrelerin ölçümleri gerçekleştirildi. Bulgular: Kruskal Wallis H testi ile yaş grupları karşılaştırıldı ve sol condylus medialis ile lateralis arası uzunluk parametresinde 1. ile 2. yaş grubu arasında sağ condylus medialis-malleolus medialis arası uzaklık parametresinde 1. yaş grubu ile diğer yaş grupları arasında, sol condylus medialis-malleolus medialis arası uzaklık parametresinde 1. ile 3. yaş grubu arasında, sağ condylus lateralis-malleolus lateralis arası uzaklık parametresinde 1. yaş grubu ile diğer yaş grupları arasında istatistiksel olarak anlamlı ilişki olduğu bulundu. One Way Anova testi ile sol condylus medialis-malleolus medialis arası uzaklık parametresinde 1. ve 3. grupları arasında anlamlı ilişki bulundu. Sol condylus medialis ile lateralis arası uzunluk (CML-RL, LL) hariç tüm parametrelerde cinsiyetler arasında istatistiksel olarak anlamlı fark olduğu sonucuna ulaşıldı (p<0.05). Sonuç: Çalışmamız sonucunda erozyona karşı dirençli olan tibia’dan belirlediğimiz parametrelerin yaş ve cinsiyeti belirlemede önemli belirteçler olduğu belirlendi. Bu yönüyle hem literatürdeki çalışmalara hem de yeni yapılacak çalışmalara katkı sağlayacağı kanaatindeyiz.
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    Bilgisayarlı Tomografi Görüntülerinde Kafatası Morfometrisinin Değerlendirilmesi ve Sefalik Indeks’in Hesaplanması
    (Harran Üniversitesi, 2022) Bakırcı, Sinan; Öner, Serkan
    Amaç: Pek çok canlı türünde kafatası ölçümleri ırkların ve etnik farklılıkların belirlenmesinde önemlidir. Ayrıca bedensel bütünlüğün bozulduğu doğal afetler gibi durumlarda, kafatası ölçümleri adli tıp bakımından kimliklendirmede ve cinsiyet belirlenmesinde önemlidir. Sefalik index, kafatasında biparietal çapın sagittal uzunluğa oranının 100 ile çarpılması ile elde edilir. Materyal ve Metod: Çalışma, sağlıklı 20-40 yaş aralığında 80 genç erişkine ait, retrospektif olarak elde edilen bilgisayarlı tomografi görüntüleri üzerinde gerçekleştirildi. Ölçümler sagittal ve koronal düzlemde yapıldı. Bulgular: Kafatası uzunluğu, kafatası genişliği ve sefalik indeks ortalama değerleri, sırasıyla, erkeklerde 182.09±6.67, 146.60±6.30 ve %80.59±4.26; kadınlarda 173.45±6,98, 140.41±6.53 ve %81.07±4.48 bulundu. Kafatası uzunluğu ve genişliği erkeklerde kadınlara göre daha fazlaydı ve aradaki fark istatistiksel olarak anlamlıydı p<0.05. Kafatası tipi yüzdeleri erkeklerde %10 Dolicocephalic, %37.5 Mesocephalic %37.5 Brachycephalic, %15 Hyperbrachycephalic; kadınlarda %7.5 Dolicocephalic, %42,5 Mesocephalic %27.5 Brachycephalic % 22.5 Hyperbrachycephalic olarak bulundu. Sefaliks indeks açısından cinsiyetler arasındaki fark anlamlı değildi p>0.05. Cephalic index, kafatası uzunluğu ile negatif yönde orta düzeyde, kafatası genişliği ile pozitif yönde orta düzeyde korelasyona sahipti. Sonuç: Çalışmamızın verilerinin anatomistler, antropologlar, arkeologlar, adli tıp uzmanları, baş bölgesi cerrahları için faydalı olacağı kanaatindeyiz. Ayrıca baş ve yüz bölgesi için eksternal kullanıma yönelik geliştirilen cihaz ve aygıtlar açısından da önemli olacaktır.
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    Comparison of pirfenidone and corticosteroid treatments at the COVID-19 pneumonia with the guide of artificial intelligence supported thoracic computed tomography
    (Wiley, 2021) Acat, Murat; Gülhan, Pınar Yıldız; Öner, Serkan; Turan, Muhammed Kamil
    Aim We aimed to investigate the effect of short-term pirfenidone treatment on prolonged COVID-19 pneumonia. Method Hospital files of patients hospitalised with a diagnosis of critical COVID-19 pneumonia from November 2020 to March 2021 were retrospectively reviewed. Chest computed tomography images taken both before treatment and 2 months after treatment, demographic characteristics and laboratory parameters of patients receiving pirfenidone + methylprednisolone (n = 13) and only methylprednisolones (n = 9) were recorded. Pulmonary function tests were performed after the second month of the treatment. CT involvement rates were determined by machine learning. Results A total of 22 patients, 13 of whom (59.1%) were using methylprednisolone + pirfenidone and 9 of whom (40.9%) were using only methylprednisolone were included. When the blood gas parameters and pulmonary function tests of the patients were compared at the end of the second month, it was found that the FEV1, FEV1%, FVC and FVC% values were statistically significantly higher in the methylprednisolone + pirfenidone group compared with the methylprednisolone group (P = .025, P = .012, P = .026 and P = .017, respectively). When the rates of change in CT scans at diagnosis and second month of treatment were examined, it was found that the involvement rates in the methylprednisolone + pirfenidone group were statistically significantly decreased (P < .001). Conclusion Antifibrotic agents can reduce fibrosis that may develop in the future. These can also help dose reduction and/or non-use strategy for methylprednisolone therapy, which has many side effects. Further large series and randomised controlled studies are needed on this subject.
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    Evaluation of congenital rib anomalies with multi-detector computed tomography in the Turkish population
    (Via Medica, 2024) Öner, Zülal; Öner, Serkan; Sahin, Necati Emre; Cay, Mahmut
    Background: This study aimed to evaluate the congenital anomalies of ribs in the Turkish population using multi-detector computed tomography (CT) and to reveal the prevalence and distribution of these anomalies according to sexes and body sides. Materials and methods: This study included 1120 individuals (592 male, 528 female) over 18 who presented to our hospital with a suspicion of COVID-19 and who had thoracic CT. Anomalies such as a bifid rib, cervical rib, fused rib, Srb anomaly, foramen rib, hypoplastic rib, absent rib, supernumerary rib, pectus carinatum, and pectus excavatum, which were previously defined in the literature, were examined. Descriptive statistics were performed with the distribution of anomalies. Comparisons were made between the sexes and body sides. Results: A prevalence of 18.57% rib variation was observed. Females had 1.3 times more variation than males. Although there was a significant difference in the distribution of anomalies by sex (p = 0.000), there was no difference in terms of body side of anomaly (p > 0.05). The most common anomaly was the hypoplastic rib, followed by the absence of a rib. While the incidence of the hypoplastic rib was similar in females and males, 79.07% of the absent ribs was seen in females (p < 0.05). The study also includes a rare case of bilateral first rib foramen. At the same time, this study includes a rare case of rib spurs extending from the left 11(th) rib to the 11(th) intercostal space. Conclusions: This study demonstrates detailed information about congenital rib anomalies in the Turkish population, which may vary between people. Knowing these anomalies is essential for anatomy, radiology, anthropology, and forensic sciences.
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    Evaluation of the Differences in Parameters Obtained from the Computed Tomography Images of the Eyeball and the Structures in the Orbit by Age and Gender
    (2024) Akyer, Nurhan; Toy, Şeyma; Seçgin, Yusuf; Şenol, Deniz; Öner, Serkan; Oner, Zulal; Turan, Muhammed Kamil
    Objective: The aim of this study is to show the variation of eyeball and orbital structures according to different age groups and gender. Method: The study was conducted on computerized tomography (CT) images of 4 age groups: 30-40, 41-50, 51-60, and over 61 years old. The parameters were, the angle between the optic nerve and axis of eyeball (A-Cr2AA), the length of the medial rectus muscle (MRML) and the length of the lateral rectus muscle (LRML) up to the Zinn ring, the thickness of the lens (LT), the length of the optic nerve from the Zinn ring (Cr2L), optic nerve thickness (Cr2T), distance between two eyeballs (BOD) and the others. Results: As a result of the study, in the comparison of males in four groups, significant difference was found between the groups in LT, Cr2L, A-Cr2AA, MRML parameters in the right eyeball and Cr2L and LRML parameters in the left eyeball (p<0.05). In the comparison of females in four groups, significant difference was found between the groups in BOD, LT, Cr2L, LRML, MRML in the right and left eyeball and Cr2T parameter in the left eyeball (p<0.05). Conclusion: As a result of the study, it was determined that age and gender differed in the determined parameters.
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    Evaluation of the effect of comorbid bronchiectasis on quality of life in patients with chronic obstructive pulmonary disease
    (Duzce Univ, Fac Medicine, 2022) Yılmaz, Cansu; Acat, Murat; Öner, Serkan; İnci, Habibe; Adahan, Didem
    Objective: The objective of this study was to evaluate the effect of comorbid bronchiectasis on quality-of-life in patients with Chronic Obstructive Pulmonary Disease (COPD). Method: 103 patients were diagnosed with COPD were included in our study. Spirometric measurements were made. The following measurement tools were used to collect data: 6-Minute Walk Test (6MWT), Modified Medical Research Council (mMRC) dyspnea scale, COPD Assessment Test (CAT), St. George Respiratory Questionnaire (SGRQ), and Short Form 36 (SF-36) quality-of-life questionnaire. Furthermore, all the patients' high Resolution Computed Tomography (HRCT) images for the last three years were included in the study. Result: 93.2% of the patients were male, with a mean age of 64.79 +/- 9.35 years. It was found that SGRQ and SF-36 quality-of-life scores decreased by half in all the patients compared to normal ones. The volume/forced vital capacity (FEV1/FVC) values in the first second of forced expiration were significantly lower in the group with bronchiectasis. A significant correlation was found to exist between the patients' mMRC dyspnea scale and CAT scores, 6MWT distances, and all subscales of SGRQ and SF-36. In addition, a significant correlation was also found to exist between FEV1 values and all subscales of SGRQ, and between subscales of SF-36. Conclusion: In our study, when we compared the quality-of-life scores of the patients with COPD and bronchiectasis with those with COPD alone, we found that the quality-of-life of both groups was impaired, but there was no significant difference between them.
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    Gender prediction using geometric morphometry with parameters of the cranium obtained from computed tomography images
    (Cukurova Univ, Fac Medicine, 2024) Secgin, Yusuf; Öner, Zülal; Öner, Serkan; Toy, Seyma
    Purpose:The gender difference of the cranium skeleton is of great importance in forensic anthropology and forensic medicine sciences. This study is based on this hypothesis and the gender prediction rate was obtained by processing cranium images obtained from computed tomography (CT) using geometric morphometry.Materials and Methods:CT images of 200 individuals between the ages of 25 and 65 were used in our study. The images were opened at the personal workstation Horos Medical Image Viewer (Version 3.0, USA) program and processed with 3D Curved Multiplanar Reconstruction (MPR). The line passing through the nasion and inion points of the images obtained as a result of the process was determined, and all images were brought to the orthogonal plane. Later, the images were overlapped and saved in JPEG format with 100% magnification. JPEG images saved were converted into TPS format, and 21 homologous landmarks were placed. Generalized Procrustes Analysis (GPA) and Principal Component Analysis (PCA) were applied to thecoordinates of landmarks, and shape variations and dimensionality were corrected by gathering the images to the center of gravity. Next, Linear Discriminant Analysis (LDA) was applied to the coordinates, the dimensionality of which was corrected. Results:The study found that 74.465% of the coordinates of 21 homologous landmarks gathered to the center of gravity could be explained with the first three PCs. As a result of the LDA applied to these coordinates, a gender prediction rate of 86.5% was obtained.In addition, a slight difference was found between the GPA sum of squares and the tangent sum of squares (0.57). Conclusion:The images of the cranium obtained from CT showed a high dimorphism by geometric morphometry analysis